在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RREB1 Antibody

  • 中文名稱:
    RREB1兔多克隆抗體
  • 貨號(hào):
    CSB-PA020516GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    RREB1
  • 別名:
    FINB antibody; Finger protein in nuclear bodies antibody; Hindsight homolog antibody; HNT antibody; LZ321 antibody; Raf responsive zinc finger protein LZ321 antibody; Raf-responsive zinc finger protein LZ321 antibody; RAS responsive element binding protein 1 antibody; Ras-responsive element-binding protein 1 antibody; RREB 1 antibody; RREB-1 antibody; Rreb1 antibody; RREB1_HUMAN antibody; Zep 1 antibody; Zep-1 antibody; Zep1 antibody; Zinc finger motif enhancer binding protein 1 antibody; Zinc finger motif enhancer-binding protein 1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Human RREB1-Specific
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. Promotes brown adipocyte differentiation. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression.
  • 基因功能參考文獻(xiàn):
    1. Of the 465,447 CpG sites analyzed, 12 showed differential methylation (false discovery rate <0.15), including markers within genes associated with monogenic diabetes (HNF4A) or obesity (RREB1). The overall methylation at HNF4A showed inverse correlations with mRNA expression levels, though non significant PMID: 29099273
    2. RREB1 cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM) of the intervertebral disc. PMID: 28341660
    3. RREB1 and CCND1 gains are common in nail apparatus melanoma PMID: 27185405
    4. Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. PMID: 26608785
    5. RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease. PMID: 25027322
    6. The pathway of RREB1/ZIP3/Zinc and its downregulation during oncogenesis exist to prevent the accumulation of cytotoxic levels of zinc during the development and progression of the malignant cells in pancreatic adenocarcinoma. PMID: 25050557
    7. RREB-1 overexpression results in down-regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer. PMID: 21360563
    8. Thus HNT and c are functional homologs at the level of DNA binding, transcriptional regulation and developmental control PMID: 24418439
    9. Data show the transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level. PMID: 24348900
    10. RREB1 is overexpressed in colorectal adenocarcinoma tumors. RREB1 repressed miR-143/145 modulates KRAS signaling. PMID: 22751122
    11. These results support a concept that downregulation of RREB-1 causes downregulation of ZIP3, which results in decreased zinc in pancreatic premalignant and carcinoma cells PMID: 22427155
    12. Data indicate the upregulation of RREB1, PDE6B, and CD209 suggests that these proteins might play important roles in the differentiation of primitive gut tube cells from embryonic stem cells (hESCs) and in primitive gut tube development into pancreas. PMID: 21792086
    13. Data show that the combination of concurrent zinc, ZIP3, and RREB-1 changes represent early events in the development of adenocarcinoma. PMID: 21613827
    14. RREB1 transcription factor splice variants are associated with urologic cancer. PMID: 21703425
    15. KRAS and RREB1 are targets of miR-143/miR-145, revealing a feed-forward mechanism that potentiates Ras signaling PMID: 21159816
    16. Ras pathway and activation of RREB-1 are involved in hZIP1 down-regulation and may play a role in the decrease of the transporter expression in prostate cancer. PMID: 19802870
    17. The p16 promoter can be downregulated by transfected human RREB, in a Ras- or Mek-dependent manner, and that the BALB/c promoter is more sensitive than DBA/2 to regulation by RREB, a ras-responsive transcriptional element with zinc-finger binding motifs. PMID: 12700664
    18. Finb functions as a sequence-specific transcriptional repressor of the hANG gene PMID: 15067362
    19. essential to reduce cell-cell adhesion when epithelial cells within an interconnected group undergo dynamic changes in cell shape PMID: 18394891
    20. Findings provide evidence that RREB-1 participates in modulating p53 transcription in response to DNA damage. PMID: 19558368
    21. This demonstration is the first of a repressor factor of HLA-G transcriptional activity taking part in HLA-G repression by epigenetic mechanisms. PMID: 19890057

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus speckle.
  • 蛋白家族:
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性:
    Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10449

    OMIM: 602209

    KEGG: hsa:6239

    UniGene: Hs.298248



主站蜘蛛池模板: 国产sp调教打屁股视频网站| 亚洲人成无码区在线观看| 精品国产乱码久久久久久乱码| 国产成人午夜在线视频a站| 岛国av动作片在线观看| 天天爽天天爽夜夜爽毛片| 伊人久久大香线蕉avapp下载| 精品国产三级a在线观看网站| 被灌满精子的波多野结衣| 亚洲一区精品无码| 国产96色在线 | 国| 国产 日韩 另类 视频一区| 色偷偷偷在线视频播放| 给我免费的视频在线观看| 久久99青青精品免费观看| 800av凹凸视频在线观看| 新国产三级视频在线播放| 极品嫩模高潮叫床| 日本一区二区三区不卡免费| 国产精品扒开腿做爽爽爽a片唱戏 久久99国产精品久久99 | 精品无码专区久久久水蜜桃| 日本另类αv欧美另类aⅴ| 97人妻精品一区二区三区| 色综合天天综合天天更新| 久久综合给久久狠狠97色| 免费吃奶摸下激烈视频| 图片区小说区激情区偷拍区| 粉嫩小泬视频无码视频软件| 欧美日本精品一区二区三区| 久久精品a亚洲国产v高清不卡 | 国产女人喷潮视频免费| 又粗又黄又猛又爽大片免费| 国产精品视频永久免费播放| 午夜高清在线无码| 2021久久超碰国产精品最新| 嫩草av久久伊人妇女超级a| 国产欧美精品一区二区三区-老狼| 中文字幕一区二区精品区| 免费国产裸体美女视频全黄| 久热在线中文字幕色999舞| 好日子在线观看视频大全免费动漫|