在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RREB1 Antibody

  • 中文名稱:
    RREB1兔多克隆抗體
  • 貨號:
    CSB-PA040279
  • 規(guī)格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    RREB1
  • 別名:
    FINB antibody; Finger protein in nuclear bodies antibody; Hindsight homolog antibody; HNT antibody; LZ321 antibody; Raf responsive zinc finger protein LZ321 antibody; Raf-responsive zinc finger protein LZ321 antibody; RAS responsive element binding protein 1 antibody; Ras-responsive element-binding protein 1 antibody; RREB 1 antibody; RREB-1 antibody; Rreb1 antibody; RREB1_HUMAN antibody; Zep 1 antibody; Zep-1 antibody; Zep1 antibody; Zinc finger motif enhancer binding protein 1 antibody; Zinc finger motif enhancer-binding protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human RREB1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. Promotes brown adipocyte differentiation. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression.
  • 基因功能參考文獻:
    1. Of the 465,447 CpG sites analyzed, 12 showed differential methylation (false discovery rate <0.15), including markers within genes associated with monogenic diabetes (HNF4A) or obesity (RREB1). The overall methylation at HNF4A showed inverse correlations with mRNA expression levels, though non significant PMID: 29099273
    2. RREB1 cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM) of the intervertebral disc. PMID: 28341660
    3. RREB1 and CCND1 gains are common in nail apparatus melanoma PMID: 27185405
    4. Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. PMID: 26608785
    5. RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease. PMID: 25027322
    6. The pathway of RREB1/ZIP3/Zinc and its downregulation during oncogenesis exist to prevent the accumulation of cytotoxic levels of zinc during the development and progression of the malignant cells in pancreatic adenocarcinoma. PMID: 25050557
    7. RREB-1 overexpression results in down-regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer. PMID: 21360563
    8. Thus HNT and c are functional homologs at the level of DNA binding, transcriptional regulation and developmental control PMID: 24418439
    9. Data show the transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level. PMID: 24348900
    10. RREB1 is overexpressed in colorectal adenocarcinoma tumors. RREB1 repressed miR-143/145 modulates KRAS signaling. PMID: 22751122
    11. These results support a concept that downregulation of RREB-1 causes downregulation of ZIP3, which results in decreased zinc in pancreatic premalignant and carcinoma cells PMID: 22427155
    12. Data indicate the upregulation of RREB1, PDE6B, and CD209 suggests that these proteins might play important roles in the differentiation of primitive gut tube cells from embryonic stem cells (hESCs) and in primitive gut tube development into pancreas. PMID: 21792086
    13. Data show that the combination of concurrent zinc, ZIP3, and RREB-1 changes represent early events in the development of adenocarcinoma. PMID: 21613827
    14. RREB1 transcription factor splice variants are associated with urologic cancer. PMID: 21703425
    15. KRAS and RREB1 are targets of miR-143/miR-145, revealing a feed-forward mechanism that potentiates Ras signaling PMID: 21159816
    16. Ras pathway and activation of RREB-1 are involved in hZIP1 down-regulation and may play a role in the decrease of the transporter expression in prostate cancer. PMID: 19802870
    17. The p16 promoter can be downregulated by transfected human RREB, in a Ras- or Mek-dependent manner, and that the BALB/c promoter is more sensitive than DBA/2 to regulation by RREB, a ras-responsive transcriptional element with zinc-finger binding motifs. PMID: 12700664
    18. Finb functions as a sequence-specific transcriptional repressor of the hANG gene PMID: 15067362
    19. essential to reduce cell-cell adhesion when epithelial cells within an interconnected group undergo dynamic changes in cell shape PMID: 18394891
    20. Findings provide evidence that RREB-1 participates in modulating p53 transcription in response to DNA damage. PMID: 19558368
    21. This demonstration is the first of a repressor factor of HLA-G transcriptional activity taking part in HLA-G repression by epigenetic mechanisms. PMID: 19890057

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus speckle.
  • 蛋白家族:
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性:
    Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10449

    OMIM: 602209

    KEGG: hsa:6239

    UniGene: Hs.298248



主站蜘蛛池模板: 免费无遮挡禁18污污网站| 夜夜澡人摸人人添人人看| 亚洲精品偷拍无码不卡av| 国产成人年无码av片在线观看 | 国产精品成熟老女人| 啦啦啦www播放日本观看| 日本一卡二卡不卡视频查询| 国产亚洲欧美日韩夜色凹凸成人| 97成人精品国语自产拍| 亚洲区小说区激情区图片区| 日韩在线 | 中文| 丰满熟妇乱子伦| 免费久久人人爽人人爽av| 蜜臀av一区二区| 免费国产白丝喷水娇喘视频| 九九热久久只有精品2| 国产日产欧产精品网站| 波多野结衣不打码视频| 免费人成视频x8x8入口| 首页 综合国产 亚洲 丝袜| 亚洲中文字幕不卡无码| 日韩好精品视频你懂的| 业余 自由 性别 成熟偷窥| 老妇高潮潮喷到猛进猛出| 日本久久高清一区二区三区毛片| 波多野结av在线无码中文 | 国产精品国产三级国av在线观看| 先锋影音男人av资源| 亚洲综合一区二区三区无码| 少妇内射兰兰久久| 国产精品无码a∨果冻传媒| 国产卡一卡二无线乱码| 免费ā片在线观看| 亚洲乱码一区二三四区ava| 国产av影片麻豆精品传媒| 三级特黄60分钟在线观看| 成在线人永久免费视频播放| 国产精品国产三级国产aⅴ下载| 日日天日日夜日日摸| 日产精品久久久久久久蜜臀| 女女互磨互喷水高潮les呻吟|