在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ras-related protein Rab-31 (RAB31)

  • 中文名稱:
    人RAB31重組蛋白
  • 貨號:
    CSB-YP614438HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RAB31重組蛋白
  • 貨號:
    CSB-EP614438HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RAB31重組蛋白
  • 貨號:
    CSB-BP614438HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RAB31重組蛋白
  • 貨號:
    CSB-MP614438HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Rab 22B; RAB 31; Rab22B; Rab31; RAB31 member RAS oncogene family; RAB31_HUMAN; Ras related protein Rab 31; Ras related protein Rab31; Ras-related protein Rab-22B; Ras-related protein Rab-31
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-194
  • 氨基酸序列
    MAIRELKVCL LGDTGVGKSS IVCRFVQDHF DHNISPTIGA SFMTKTVPCG NELHKFLIWD TAGQERFHSL APMYYRGSAA AVIVYDITKQ DSFYTLKKWV KELKEHGPEN IVMAIAGNKC DLSDIREVPL KDAKEYAESI GAIVVETSAK NAINIEELFQ GISRQIPPLD PHENGNNGTI KVEKPTMQAS RRCC
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
  • 基因功能參考文獻:
    1. the role of Rab31 in cancer progression, is reported. PMID: 26245486
    2. this study provides the evidence of Rab31 overexpression in HCC, and Rab31 is potentially used as a novel biomarker of poor prognosis in patients with HCC. PI3K/AKT/Bcl-2/BAX axis was involved in Rab31-promoting HCC progression. PMID: 26044564
    3. Data indicate that early endosome antigen 1 (EEA1) is important for the small GTPase Rab31-mediated enhancement of ligand-bound EGF receptor (EGFR) endocytic trafficking. PMID: 24644286
    4. MUC1-C and Rab31 function in an autoinductive loop that contributes to overexpression of MUC1-C in breast cancer cells. PMID: 22792175
    5. Overexpression of rab31 in breast cancer cells leads to a switch from an invasive to a proliferative phenotype as indicated by an increased cell proliferation, reduced adhesion and invasion in vitro, and a reduced capacity to form lung metastases in vivo. PMID: 22920728
    6. Neither UPARwt, nor UPAR-del4/5 nor RAB31 mRNA expression levels were found to be prognostic markers in advanced ovarian cancer. PMID: 21848504
    7. RIN3 specifically acts as a GEF for Rab31. PMID: 21586568
    8. Thus, Rab22B may have a role in anterograde exit from the trans-Golgi network . PMID: 17678623
    9. uPAR-del4/5 and rab31 mRNA represent independent prognostic markers in breast cancer and may be components of different, but possibly associated, tumor-relevant signaling pathways. PMID: 17952591
    10. Rab22B possibly plays role in regulating epidermal growth factor receptor (EGFR) and mannose 6-phosphate receptor (M6PR) transport into late endosomes. PMID: 19725050

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus, trans-Golgi network. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族:
    Small GTPase superfamily, Rab family
  • 組織特異性:
    Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas.
  • 數據庫鏈接:

    HGNC: 9771

    OMIM: 605694

    KEGG: hsa:11031

    STRING: 9606.ENSP00000304565

    UniGene: Hs.744887



主站蜘蛛池模板: 四川丰满少妇被弄到高潮| 精品国产偷窥一区二区| 亚洲男人av香蕉爽爽爽爽| 一本无码人妻在中文字幕免费| 7777精品久久久大香线蕉| 黄页网站在线观看免费视频| 色先锋资源久久综合5566| 国产女人高潮嗷嗷嗷叫| 久久大蕉香蕉免费| 天堂网在线www中文| 日本高清视频wwww色 | 久久视频在线视频精品| 久久99精品久久久久久蜜芽 | 最新系列国产专区|亚洲国产| av毛片无码中文字幕不卡 | 亚洲精品乱码久久久久久久久久久久 | 精品av中文字幕在线毛片 | 末成年女av片一区二区| 国产一区二区三区免费观看在线| 久久精品免费一区二区| 欧美性xxxxx极品少妇| 又黄又硬又湿又刺激视频免费 | 老熟女五十路乱子交尾中出一区| 日本成熟老妇乱| av毛片无码中文字幕不卡| 国产超级va在线观看视频| 亚洲成a人片在线观看国产| 久久亚洲国产精品成人av秋霞| 18禁黄网站禁片免费观看国产| 春药高潮抽搐流白浆在线观看| 亚洲成a人无码| 国产成人无码网站| 色喜国模李晴超大尺度| 99热久久这里只精品国产www| 少妇的渴望hd高清在线播放| 国产精品无码专区| 欧美亚洲一区二区三区| 午夜免费啪视频在线18| 亚洲熟妇av一区| 虎白女粉嫩尤物福利视频| 亚洲精品日韩一区二区电影|