在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ras-related protein Rab-17 (RAB17)

  • 中文名稱:
    人RAB17重組蛋白
  • 貨號:
    CSB-YP863944HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RAB17重組蛋白
  • 貨號:
    CSB-EP863944HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RAB17重組蛋白
  • 貨號:
    CSB-BP863944HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RAB17重組蛋白
  • 貨號:
    CSB-MP863944HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RAB17
  • Uniprot No.:
  • 別名:
    AW413472; FLJ12538; OTTHUMP00000164417; OTTHUMP00000202805; Rab 17; Rab17; RAB17 member RAS oncogene family; RAB17_HUMAN; Ras related protein Rab 17; Ras related protein Rab17; Ras-related protein Rab-17
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-212
  • 氨基酸序列
    MAQAHRTPQP RAAPSQPRVF KLVLLGSGSV GKSSLALRYV KNDFKSILPT VGCAFFTKVV DVGATSLKLE IWDTAGQEKY HSVCHLYFRG ANAALLVYDI TRKDSFLKAQ QWLKDLEEEL HPGEVLVMLV GNKTDLSQER EVTFQEGKEF ADSQKLLFME TSAKLNHQVS EVFNTVAQEL LQRSDEEGQA LRGDAAVALN KGPARQAKCC AH
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration.
  • 基因功能參考文獻:
    1. Mass spectrometry and immunofluorescence microscopy of efferosomes and phagosomes in macrophages demonstrated that efferosomes lacked the proteins required for antigen presentation and instead recruited the recycling regulator Rab17. PMID: 28005073
    2. Down-regulation of Rab17 promotes tumourigenic properties of hepatocellular carcinoma cells via Erk MAPK signaling. PMID: 26191189
    3. Rab17 might act as a tumour suppressor gene in hepatocellular carcinoma , and the anti-tumour effects of Rab17 might be partially mediated by the Erk pathway. PMID: 25707355
    4. These results suggest that Rab17 and Rab17-mediated REs are involved in Streptococcus pyogenes-containing autophagosome-like vacuole formation. PMID: 25052408
    5. Knockdown of either Rab17 or liprin-beta2 restores invasiveness of ERK2-depleted cells, indicating that ERK2 drives invasion of MDA-MB-231 cells by suppressing expression of these genes. PMID: 22328529
    6. Data reveal new functions for recycling endosomes and Rab17 in pigmentation through a distal step in the process of melanosome release via filopodia. PMID: 21291502

    顯示更多

    收起更多

  • 亞細胞定位:
    Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cell projection, dendrite.
  • 蛋白家族:
    Small GTPase superfamily, Rab family
  • 組織特異性:
    Expressed in melanocytes (at protein level).
  • 數據庫鏈接:

    HGNC: 16523

    OMIM: 602206

    KEGG: hsa:64284

    STRING: 9606.ENSP00000264601

    UniGene: Hs.44278



主站蜘蛛池模板: 国产精品久久久久久亚洲色| 精品熟女少妇av免费观看| 国产成人精品123区免费视频| 国产手机在线精品| 国产 一二三四五六| 天堂俺去俺来也www色官网| 精品无人区一区二区三区| 黑人上司粗大拔不出来电影| 亚洲国产成人久久久网站| 亚洲精品久久久无码大桥未久| 亚洲精品国男人在线视频| 成人亚洲国产精品一区不卡| 亚洲爱婷婷色婷婷五月| 乱熟女高潮一区二区在线| 性色欲情网站iwww| 影音先锋人妻av中文字幕久久| 男女裸交无遮挡啪啪激情试看| 亚洲成a∧人片在线播放调教| 欧美牲交a欧美牲交aⅴ免费| 久久午夜福利无码1000合集| 樱花草在线社区www中国中文| 女高中生第一次破苞av| 无码视频免费一区二区三区| 国产无遮挡又黄又爽在线观看| 精品无码国产av一区二区| 亚洲欧洲日产国码久在线| 免费国产成人高清在线视频| 日韩欧美群交p内射捆绑| 久久99精品久久久久久2021| 国产乱了伦视频大全亚琴影院 | 好男人社区www在线官网| 8ⅹ8x擦拨擦拨成人免费视频| 无码加勒比一区二区三区四区| 国产丝袜一区视频在线观看| 无尺码精品产品日韩| 粉嫩被粗大进进出出视频| 欧美日韩国产专区一区二区| 久久婷婷成人综合色| 性做久久久久久| 不卡无码av一区二区三区| 熟妇无码熟妇毛片|