在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Ras and Rab interactor 1 (RIN1)

Recombinant Human Ras and Rab interactor 1 (RIN1)

  • 中文名稱：
    人RIN1重組蛋白
  • 貨號：
    CSB-YP019726HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RIN1重組蛋白
  • 貨號：
    CSB-EP019726HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RIN1重組蛋白
  • 貨號：
    CSB-EP019726HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RIN1重組蛋白
  • 貨號：
    CSB-BP019726HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RIN1重組蛋白
  • 貨號：
    CSB-MP019726HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    RIN1; Ras and Rab interactor 1; Ras inhibitor JC99; Ras interaction/interference protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-783
  • 氨基酸序列
    MESPGESGAG SPGAPSPSSF TTGHLAREKP AQDPLYDVPN ASGGQAGGPQ RPGRVVSLRE RLLLTRPVWL QLQANAAAAL HMLRTEPPGT FLVRKSNTRQ CQALCMRLPE ASGPSFVSSH YILESPGGVS LEGSELMFPD LVQLICAYCH TRDILLLPLQ LPRAIHHAAT HKELEAISHL GIEFWSSSLN IKAQRGPAGG PVLPQLKARS PQELDQGTGA ALCFFNPLFP GDLGPTKREK FKRSFKVRVS TETSSPLSPP AVPPPPVPVL PGAVPSQTER LPPCQLLRRE SSVGYRVPAG SGPSLPPMPS LQEVDCGSPS SSEEEGVPGS RGSPATSPHL GRRRPLLRSM SAAFCSLLAP ERQVGRAAAA LMQDRHTAAG QLVQDLLTQV RAGPEPQELQ GIRQALSRAR AMLSAELGPE KLLSPKRLEH VLEKSLHCSV LKPLRPILAA RLRRRLAADG SLGRLAEGLR LARAQGPGAF GSHLSLPSPV ELEQVRQKLL QLLRTYSPSA QVKRLLQACK LLYMALRTQE GEGAGADEFL PLLSLVLAHC DLPELLLEAE YMSELLEPSL LTGEGGYYLT SLSASLALLS GLGQAHTLPL SPVQELRRSL SLWEQRRLPA THCFQHLLRV AYQDPSSGCT SKTLAVPPEA SIATLNQLCA TKFRVTQPNT FGLFLYKEQG YHRLPPGALA HRLPTTGYLV YRRAEWPETQ GAVTEEEGSG QSEARSRGEE QGCQGDGDAG VKASPRDIRE QSETTAEGGQ GQAQEGPAQP GEPEAEGSRA AEE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
  • 基因功能參考文獻：
    1. Findings suggest that RIN1 plays an important oncogenic role in clear cell renal cell carcinoma malignancy by activation of EGFR signaling through interacting with Rab25. PMID: 28612496
    2. Smad2 is a key scaffold, allowing RIN1 to act as a GTP exchange factor for MFN2-GTPase activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion. PMID: 27184078
    3. Overexpression experiments in tandem with pull-down assays indicated that specific Ser291/292 phosphorylation of RIN1 favored binding to activated Ras PMID: 27137893
    4. analysis of a novel deregulated mechanism in chronic myeloid leukemia patients, indicating BIN1 and RIN1 as players in the maintenance of the abnormal RTK signaling in this hematological disease PMID: 26194865
    5. Findings suggest that RIN1 orchestrates RAB5 activation, ABL kinase activation and BIN1 recruitment to determine EGFR fate. PMID: 22976291
    6. over-expression of RIN1 may play an important role in the progression of non-small cell lung cancer and RIN1 expression may offer a valuable marker for predicting the outcome of patients with NSCLC PMID: 21925717
    7. RIN1 plays an important role in gastric adenocarcinoma progression and that a high RIN1 expression predicts an unfavorable prognosis in gastric adenocarcinoma patients. PMID: 22562267
    8. RIN1 expression could be a potential prognostic predictor for the melanoma patients and provide a potential target therapy for melanoma treatment. PMID: 22627834
    9. RIN1 expression could be a potential prognostic predictor for bladder urothelial carcinoma (UC) patients. PMID: 22249975
    10. These data identify a novel PKD signaling pathway through RIN1 and Abl kinases that is involved in the regulation of actin remodeling and cell migration. PMID: 21209314
    11. BCR-ABL1 kinase activity is regulated by RIN1 PMID: 21102429
    12. Plays an important role in both insulin receptor membrane trafficking and signaling. PMID: 16457816
    13. These results indicate that the RIN1 gene serves as an important signal transduction system for evaluating the malignancy of colorectal cancer. PMID: 17390061
    14. Rin1 regulates EGFR degradation in cooperation with STAM PMID: 17403676
    15. In a tumor cell line, RIN1 silencing may contribute to breast cancer progression. PMID: 18089779
    16. Specific residues of RIN1 are required for its interaction with Rab5, binding to the endosomal membranes and subsequent regulation of the fusion reaction. PMID: 19032933
    17. Mutations in the Vps9 domain of Rin1 lead to a loss-of-function phenotype, indicating a specific structure-function relationship between Rab5 and Rin1. PMID: 19118546
    18. Data demonstrate that proper internalization and endocytic trafficking are critical for EGFR-mediated signaling in A549 cells and suggest that up-regulation of Rin1 in A549 cell lines may contribute to their proliferative nature. PMID: 19570984
    19. the novel RIN1 mRNA was found to be expressed in gastric and colon cancer cell lines, suggesting that it is an important gene for the function of cancer cells. PMID: 19806790

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.
  • 蛋白家族：
    RIN (Ras interaction/interference) family
  • 組織特異性：
    Expressed in all tissues examined with high levels in brain, placenta and pancreas.
  • 數據庫鏈接：

    HGNC: 18749

    OMIM: 605965

    KEGG: hsa:9610

    STRING: 9606.ENSP00000310406

    UniGene: Hs.1030



主站蜘蛛池模板： 免费无码在线播放av| 国产精品第一区揄拍无码| 国产又爽又黄又刺激的视频| 国语自产拍在线观看对白| 嫩草伊人久久精品少妇av| 久久精品国产亚洲7777| 狼色精品人妻在线视频| 无码少妇精品一区二区免费动态| 亚洲mv国产mv在线mv综合试看| 韩国 欧美 日产 国产精品| 欧美综合区自拍亚洲综合绿色| 国产欧美va天堂在线观看视频| 色鬼7777久久| 东京道一本热中文字幕| 性欧美俄罗斯极品| 免费午夜理论不卡| 久久精品一区二区免费播放| 国产日韩一区二区三免费高清| 日本理伦片午夜理伦片| 99国产在线精品视频| 无码日日模日日碰夜夜爽| 玩弄少妇人妻中文字幕| 亚洲人av高清无码| 欧美人与动牲交a欧美| 国产激情无码一区二区app| 国产成人18黄网站| 国产精品视频永久免费播放| 中文在线а√在线| 青青草国产精品免费观看| 亚洲国产美女久久久久| 天天干天天日夜夜操| 亚洲欧洲免费无码| 色婷婷五月综合久久| 久久久99精品成人片| 久久久久久人妻精品一区| 国产精品久久久久久久久电影网| 国精品无码一区二区三区在线蜜臀| 99日本精品永久免费久久| 伊人色综合一区二区三区影院视频 | 国产97在线 | 日韩| 天天澡日日澡狠狠欧美老妇 |