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  4. RIN1 Antibody, FITC conjugated

RIN1 Antibody, FITC conjugated

  • 中文名稱：
    RIN1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA019726LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RIN1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    RIN1 antibody; Ras and Rab interactor 1 antibody; Ras inhibitor JC99 antibody; Ras interaction/interference protein 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ras and Rab interactor 1 protein (192-341AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
  • 基因功能參考文獻：
    1. Findings suggest that RIN1 plays an important oncogenic role in clear cell renal cell carcinoma malignancy by activation of EGFR signaling through interacting with Rab25. PMID: 28612496
    2. Smad2 is a key scaffold, allowing RIN1 to act as a GTP exchange factor for MFN2-GTPase activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion. PMID: 27184078
    3. Overexpression experiments in tandem with pull-down assays indicated that specific Ser291/292 phosphorylation of RIN1 favored binding to activated Ras PMID: 27137893
    4. analysis of a novel deregulated mechanism in chronic myeloid leukemia patients, indicating BIN1 and RIN1 as players in the maintenance of the abnormal RTK signaling in this hematological disease PMID: 26194865
    5. Findings suggest that RIN1 orchestrates RAB5 activation, ABL kinase activation and BIN1 recruitment to determine EGFR fate. PMID: 22976291
    6. over-expression of RIN1 may play an important role in the progression of non-small cell lung cancer and RIN1 expression may offer a valuable marker for predicting the outcome of patients with NSCLC PMID: 21925717
    7. RIN1 plays an important role in gastric adenocarcinoma progression and that a high RIN1 expression predicts an unfavorable prognosis in gastric adenocarcinoma patients. PMID: 22562267
    8. RIN1 expression could be a potential prognostic predictor for the melanoma patients and provide a potential target therapy for melanoma treatment. PMID: 22627834
    9. RIN1 expression could be a potential prognostic predictor for bladder urothelial carcinoma (UC) patients. PMID: 22249975
    10. These data identify a novel PKD signaling pathway through RIN1 and Abl kinases that is involved in the regulation of actin remodeling and cell migration. PMID: 21209314
    11. BCR-ABL1 kinase activity is regulated by RIN1 PMID: 21102429
    12. Plays an important role in both insulin receptor membrane trafficking and signaling. PMID: 16457816
    13. These results indicate that the RIN1 gene serves as an important signal transduction system for evaluating the malignancy of colorectal cancer. PMID: 17390061
    14. Rin1 regulates EGFR degradation in cooperation with STAM PMID: 17403676
    15. In a tumor cell line, RIN1 silencing may contribute to breast cancer progression. PMID: 18089779
    16. Specific residues of RIN1 are required for its interaction with Rab5, binding to the endosomal membranes and subsequent regulation of the fusion reaction. PMID: 19032933
    17. Mutations in the Vps9 domain of Rin1 lead to a loss-of-function phenotype, indicating a specific structure-function relationship between Rab5 and Rin1. PMID: 19118546
    18. Data demonstrate that proper internalization and endocytic trafficking are critical for EGFR-mediated signaling in A549 cells and suggest that up-regulation of Rin1 in A549 cell lines may contribute to their proliferative nature. PMID: 19570984
    19. the novel RIN1 mRNA was found to be expressed in gastric and colon cancer cell lines, suggesting that it is an important gene for the function of cancer cells. PMID: 19806790

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  • 亞細胞定位：
    Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.
  • 蛋白家族：
    RIN (Ras interaction/interference) family
  • 組織特異性：
    Expressed in all tissues examined with high levels in brain, placenta and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18749

    OMIM: 605965

    KEGG: hsa:9610

    STRING: 9606.ENSP00000310406

    UniGene: Hs.1030



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