在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RIN1 Antibody, HRP conjugated

RIN1 Antibody, HRP conjugated

  • 中文名稱：
    RIN1兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA019726LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RIN1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    RIN1 antibody; Ras and Rab interactor 1 antibody; Ras inhibitor JC99 antibody; Ras interaction/interference protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ras and Rab interactor 1 protein (192-341AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
  • 基因功能參考文獻：
    1. Findings suggest that RIN1 plays an important oncogenic role in clear cell renal cell carcinoma malignancy by activation of EGFR signaling through interacting with Rab25. PMID: 28612496
    2. Smad2 is a key scaffold, allowing RIN1 to act as a GTP exchange factor for MFN2-GTPase activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion. PMID: 27184078
    3. Overexpression experiments in tandem with pull-down assays indicated that specific Ser291/292 phosphorylation of RIN1 favored binding to activated Ras PMID: 27137893
    4. analysis of a novel deregulated mechanism in chronic myeloid leukemia patients, indicating BIN1 and RIN1 as players in the maintenance of the abnormal RTK signaling in this hematological disease PMID: 26194865
    5. Findings suggest that RIN1 orchestrates RAB5 activation, ABL kinase activation and BIN1 recruitment to determine EGFR fate. PMID: 22976291
    6. over-expression of RIN1 may play an important role in the progression of non-small cell lung cancer and RIN1 expression may offer a valuable marker for predicting the outcome of patients with NSCLC PMID: 21925717
    7. RIN1 plays an important role in gastric adenocarcinoma progression and that a high RIN1 expression predicts an unfavorable prognosis in gastric adenocarcinoma patients. PMID: 22562267
    8. RIN1 expression could be a potential prognostic predictor for the melanoma patients and provide a potential target therapy for melanoma treatment. PMID: 22627834
    9. RIN1 expression could be a potential prognostic predictor for bladder urothelial carcinoma (UC) patients. PMID: 22249975
    10. These data identify a novel PKD signaling pathway through RIN1 and Abl kinases that is involved in the regulation of actin remodeling and cell migration. PMID: 21209314
    11. BCR-ABL1 kinase activity is regulated by RIN1 PMID: 21102429
    12. Plays an important role in both insulin receptor membrane trafficking and signaling. PMID: 16457816
    13. These results indicate that the RIN1 gene serves as an important signal transduction system for evaluating the malignancy of colorectal cancer. PMID: 17390061
    14. Rin1 regulates EGFR degradation in cooperation with STAM PMID: 17403676
    15. In a tumor cell line, RIN1 silencing may contribute to breast cancer progression. PMID: 18089779
    16. Specific residues of RIN1 are required for its interaction with Rab5, binding to the endosomal membranes and subsequent regulation of the fusion reaction. PMID: 19032933
    17. Mutations in the Vps9 domain of Rin1 lead to a loss-of-function phenotype, indicating a specific structure-function relationship between Rab5 and Rin1. PMID: 19118546
    18. Data demonstrate that proper internalization and endocytic trafficking are critical for EGFR-mediated signaling in A549 cells and suggest that up-regulation of Rin1 in A549 cell lines may contribute to their proliferative nature. PMID: 19570984
    19. the novel RIN1 mRNA was found to be expressed in gastric and colon cancer cell lines, suggesting that it is an important gene for the function of cancer cells. PMID: 19806790

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.
  • 蛋白家族：
    RIN (Ras interaction/interference) family
  • 組織特異性：
    Expressed in all tissues examined with high levels in brain, placenta and pancreas.
  • 數據庫鏈接：

    HGNC: 18749

    OMIM: 605965

    KEGG: hsa:9610

    STRING: 9606.ENSP00000310406

    UniGene: Hs.1030



主站蜘蛛池模板： 99久久久无码国产精品9| 最新亚洲人成网站在线观看| 全部免费毛片在线播放| 香蕉成人伊视频在线观看| 亚洲最大的imax影院| 人妻洗澡被强公日日澡| 国产蜜芽尤物在线一区| 日韩免费一区二区三区高清| 在线天堂资源www中文| 精品国产va久久久久久久冰| 日韩人妻无码精品久久久不卡| 久久无码人妻丰满熟妇区毛片| а√天堂8资源中文在线| 国产av区男人的天堂| 午夜人成免费视频| 国产精品久久久爽爽爽麻豆色哟哟| 天天躁日日躁狠狠躁一区| 亚洲精品成人片在线观看精品字幕 | 美女露出奶头扒开尿口视频直播 | 成人免费看www网址入口| 冲田杏梨av一区二区三区| 国产精品星空无限传媒| 免费无码专区在线视频| 亚洲欧美在线观看| 狂野欧美性猛交免费视频| 久久精品2021国产| 青乐娱精品视频一国产分类 | 久久精品九九热无码免贵| 亚洲欧美日韩精品色xxx| av天堂永久资源网亚洲高清 | 少妇激情作爱视频| 国产偷窥熟妇高潮呻吟| 国产一区二区三区影院| 国产成人高清精品免费| 日产精品卡二卡三卡四卡区满十八| а天堂中文在线官网| 亚洲精品无码av专区最新| 久久无码超清激情av| 天堂网在线观看| 麻豆国产人妻欲求不满谁演的| 一本色道av久久精品+网站|