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  4. Recombinant Human Ras GTPase-activating-like protein IQGAP2 (IQGAP2), partial

Recombinant Human Ras GTPase-activating-like protein IQGAP2 (IQGAP2), partial

  • 中文名稱：
    人IQGAP2重組蛋白
  • 貨號(hào)：
    CSB-YP615701HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人IQGAP2重組蛋白
  • 貨號(hào)：
    CSB-EP615701HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人IQGAP2重組蛋白
  • 貨號(hào)：
    CSB-EP615701HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人IQGAP2重組蛋白
  • 貨號(hào)：
    CSB-BP615701HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人IQGAP2重組蛋白
  • 貨號(hào)：
    CSB-MP615701HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    IQ motif containing GTPase activating protein 2; IQGA2_HUMAN; Iqgap2; Ras GTPase activating-like protein; Ras GTPase-activating-like protein IQGAP2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
  • 基因功能參考文獻(xiàn)：
    1. IQGAP2 expression correlated positively with survivability, on the contrary, IQGAP3 expression levels correlated inversely with survivability PMID: 29073199
    2. The structural basis for Cdc42-induced dimerization of IQGAP1 and IQGAP2 has been uncovered. PMID: 27524202
    3. The most frequently identified and connected to preterm birth genes in the exome library were IGF1, ATM and IQGAP2. PMID: 27163930
    4. IQGAP2 TagSNP rs457717 (A/G) was not associated with Age-Related Hearing impairment in Han male Chinese population. PMID: 26187738
    5. Thus, these data identified IQGAP2 as a novel tumor suppressor for ovarian cancer to inhibit cell invasion through regulating Wnt/b-catenin signaling, and provided a new biomarker and potential therapeutic strategy for this disease. PMID: 26549344
    6. we identified IQGAP2 as a human and zebrafish podocyte gene product that is downregulated in microarray data sets from kidney biopsies of human patients with focal segmental glomerulosclerosis and minimal change nephrotic syndrome. PMID: 26154927
    7. Data show that IQ motif-containing GTPase-activating protein 2 (IQGAP2) expression is altered in colitis. PMID: 26047140
    8. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardiovascular system, pancreas, and lung. (Review) PMID: 25722290
    9. Mammalian IQGAP proteins may play a role in cytokinesis by regulating the localization of key cytokinesis regulatory proteins to the contractile apparatus during mitosis. PMID: 25229330
    10. Low IQGAP2 expression was associated with hepatocellular carcinoma. PMID: 24998570
    11. The first IQ-motifs from IQGAP2 and IQGAP3 form transient interactions with calmodulin in the absence of calcium. PMID: 21299499
    12. observations strongly indicate that IQGAP2 is a surveillance type of tumour suppressor for prostate cancer PMID: 22406297
    13. increased IQGAP1 and/or decreased IQGAP2 contribute to the pathogenesis of human HCC. PMID: 20977743
    14. The top-ranked SNP, rs457717 for association with age-related hearing impairment(P-value 3.55 x 10(-7)), was localised in an intron of the IQ motif-containing GTPase-activating-like protein (IQGAP2). PMID: 20068591
    15. The gene for the putative rac1/cdc42 effector protein IQGAP2 was found in the PAR gene cluster at 5q13, flanked by PAR1 & encompassing PAR3. It functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. PMID: 12515716
    16. silencing of IQGAP2 by promoter methylation may contribute to gastric cancer development. PMID: 17957782

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  • 組織特異性：
    Isoform 2 expression is enhanced in testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6111

    OMIM: 605401

    KEGG: hsa:10788

    STRING: 9606.ENSP00000274364

    UniGene: Hs.291030



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