在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. IQGAP2 Antibody

IQGAP2 Antibody

  • 中文名稱：
    IQGAP2兔多克隆抗體
  • 貨號：
    CSB-PA142299
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA142299(IQGAP2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA142299(IQGAP2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA142299(IQGAP2 Antibody) at dilution 1/350 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    IQ motif containing GTPase activating protein 2 antibody; IQGA2_HUMAN antibody; Iqgap2 antibody; Ras GTPase activating-like protein antibody; Ras GTPase-activating-like protein IQGAP2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human IQGAP2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:30-1:150
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
  • 基因功能參考文獻：
    1. IQGAP2 expression correlated positively with survivability, on the contrary, IQGAP3 expression levels correlated inversely with survivability PMID: 29073199
    2. The structural basis for Cdc42-induced dimerization of IQGAP1 and IQGAP2 has been uncovered. PMID: 27524202
    3. The most frequently identified and connected to preterm birth genes in the exome library were IGF1, ATM and IQGAP2. PMID: 27163930
    4. IQGAP2 TagSNP rs457717 (A/G) was not associated with Age-Related Hearing impairment in Han male Chinese population. PMID: 26187738
    5. Thus, these data identified IQGAP2 as a novel tumor suppressor for ovarian cancer to inhibit cell invasion through regulating Wnt/b-catenin signaling, and provided a new biomarker and potential therapeutic strategy for this disease. PMID: 26549344
    6. we identified IQGAP2 as a human and zebrafish podocyte gene product that is downregulated in microarray data sets from kidney biopsies of human patients with focal segmental glomerulosclerosis and minimal change nephrotic syndrome. PMID: 26154927
    7. Data show that IQ motif-containing GTPase-activating protein 2 (IQGAP2) expression is altered in colitis. PMID: 26047140
    8. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardiovascular system, pancreas, and lung. (Review) PMID: 25722290
    9. Mammalian IQGAP proteins may play a role in cytokinesis by regulating the localization of key cytokinesis regulatory proteins to the contractile apparatus during mitosis. PMID: 25229330
    10. Low IQGAP2 expression was associated with hepatocellular carcinoma. PMID: 24998570
    11. The first IQ-motifs from IQGAP2 and IQGAP3 form transient interactions with calmodulin in the absence of calcium. PMID: 21299499
    12. observations strongly indicate that IQGAP2 is a surveillance type of tumour suppressor for prostate cancer PMID: 22406297
    13. increased IQGAP1 and/or decreased IQGAP2 contribute to the pathogenesis of human HCC. PMID: 20977743
    14. The top-ranked SNP, rs457717 for association with age-related hearing impairment(P-value 3.55 x 10(-7)), was localised in an intron of the IQ motif-containing GTPase-activating-like protein (IQGAP2). PMID: 20068591
    15. The gene for the putative rac1/cdc42 effector protein IQGAP2 was found in the PAR gene cluster at 5q13, flanked by PAR1 & encompassing PAR3. It functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. PMID: 12515716
    16. silencing of IQGAP2 by promoter methylation may contribute to gastric cancer development. PMID: 17957782

    顯示更多

    收起更多

  • 組織特異性：
    Isoform 2 expression is enhanced in testis.
  • 數據庫鏈接：

    HGNC: 6111

    OMIM: 605401

    KEGG: hsa:10788

    STRING: 9606.ENSP00000274364

    UniGene: Hs.291030



主站蜘蛛池模板： 亚洲色大成网站www永久麻豆| 亚洲中文字幕无码久久精品1| 国产成人精品三上悠亚| 无码熟熟妇丰满人妻啪啪| 真实国产乱子伦在线视频| 欧美最猛黑人xxxxx猛交| 国外av无码精品国产精品| 亚洲中文无码人a∨在线导航| 国产午夜精品一二区理论影院| 欧美毛多水多肥妇| 巨爆乳无码视频在线观看| 亚洲欧洲av无码专区| 偷自拍亚洲视频在线观看99| 国产欧美va欧美va香蕉在线| 高清无码午夜福利视频| 老湿机国产福利视频| 亚洲国产日韩制服在线观看| 啦啦啦www在线观看免费视频 | 五十路熟女丰满大屁股| 国产激情久久久久影院老熟女| 青青草无码伊人久久| 国产亚洲精品久久久久久禁果tv| 宅男噜噜噜66网站在线观看| 欧美人与禽zoz0性伦交| 亚洲日产韩国一二三四区| 狠狠躁天天躁无码中文字幕| 国产乱子夫妻xx黑人xyx真爽| 一本色道无码道在线观看| 免费人成黄页在线观看国产| 浪潮av激情高潮国产精品| 又黄又爽又猛的视频免费| 国产美女午夜福利视频| 久久精品国产99国产精2021| 国产亚洲精品久久久久久无几年桃| 亚洲成在人线av品善网好看| 天堂资源在线官网| 夜夜躁狠狠躁日日躁| 久久亚洲精品国产亚洲老地址| 久久亚洲精品无码av宋| 国内精品久久久久久久小说| 国产无线乱码一区二三区|