在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ran GTPase-activating protein 1 (RANGAP1)

  • 中文名稱:
    人RANGAP1重組蛋白
  • 貨號:
    CSB-YP019318HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RANGAP1重組蛋白
  • 貨號:
    CSB-EP019318HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人RANGAP1重組蛋白
  • 貨號:
    CSB-EP019318HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RANGAP1重組蛋白
  • 貨號:
    CSB-BP019318HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RANGAP1重組蛋白
  • 貨號:
    CSB-MP019318HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RANGAP1
  • Uniprot No.:
  • 別名:
    Fug 1; Fug1; GTPase-activating protein, RAN, 1; KIAA1835; MGC20266; OTTHUMP00000028918; OTTHUMP00000198755; OTTHUMP00000198756; OTTHUMP00000198757; OTTHUMP00000198758; RAGP1_HUMAN; Ran 1; RAN GTPase activating protein 1; Ran GTPase-activating protein 1; Ran1; RANGAP 1; RANGAP; RanGAP1; SD; Segregation distorter homolog; Segregation distortion
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區(qū)域:
    2-587
  • 氨基酸序列
    ASEDIAKLA ETLAKTQVAG GQLSFKGKSL KLNTAEDAKD VIKEIEDFDS LEALRLEGNT VGVEAARVIA KALEKKSELK RCHWSDMFTG RLRTEIPPAL ISLGEGLITA GAQLVELDLS DNAFGPDGVQ GFEALLKSSA CFTLQELKLN NCGMGIGGGK ILAAALTECH RKSSAQGKPL ALKVFVAGRN RLENDGATAL AEAFRVIGTL EEVHMPQNGI NHPGITALAQ AFAVNPLLRV INLNDNTFTE KGAVAMAETL KTLRQVEVIN FGDCLVRSKG AVAIADAIRG GLPKLKELNL SFCEIKRDAA LAVAEAMADK AELEKLDLNG NTLGEEGCEQ LQEVLEGFNM AKVLASLSDD EDEEEEEEGE EEEEEAEEEE EEDEEEEEEE EEEEEEEPQQ RGQGEKSATP SRKILDPNTG EPAPVLSSPP PADVSTFLAF PSPEKLLRLG PKSSVLIAQQ TDTSDPEKVV SAFLKVSSVF KDEATVRMAV QDAVDALMQK AFNSSSFNSN TFLTRLLVHM GLLKSEDKVK AIANLYGPLM ALNHMVQQDY FPKALAPLLL AFVTKPNSAL ESCSFARHSL LQTLYKV
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export. Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export.
  • 基因功能參考文獻:
    1. RanGAP1 upregulation is associated with drug resistance in Chronic Myeloid Leukemia. PMID: 27228340
    2. Abnormal localization of RanGAP1 was found in cortex of Huntington's disease patients. PMID: 28384474
    3. our results elucidate that RanGAP1 is actively transported between the nuclear and cytoplasmic compartments, and that the cytoplasmic and NPC localization of RanGAP1 is dependent on CRM1-mediated nuclear export. PMID: 26506250
    4. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 and NF-kappaB p65 nuclear entry in T cells PMID: 26321253
    5. Differentiation of human coronary artery smooth muscle cell to a contractile phenotype by stepwise serum depletion leads to significant reduction of RanGAP1 protein levels. PMID: 24988324
    6. Analysis of the dynamics of E2(Ubc9)-SUMO-Target(RanGAP1) in the absence and presence of E3(RanBP2) revealed that two different allosteric sites regulate the ligase activity. PMID: 21216249
    7. the RanGAP1 consensus sumoylation site and SUMO-1 C terminus are both conformationally flexible PMID: 15355965
    8. the 3.0-A crystal structure of a four-protein complex of Ubc9, a Nup358/RanBP2 E3 ligase domain (IR1-M) and SUMO-1 conjugated to the carboxy-terminal domain of RanGAP1 PMID: 15931224
    9. RanGAP1 is phosphorylated on Ser-358 in vivo & in vitro. Phosphorylated RanGAP1, but not a mutant at 358S, formed a stable ternary complex with Ran and RanBP1 in vivo, suggesting that its 358S phosphorylation affects the Ran system. PMID: 16428860
    10. The results of this study strengthen the conclusion that mel-18 functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RanGAP1. PMID: 18706886

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族:
    RNA1 family
  • 組織特異性:
    Highly expressed in brain, thymus and testis.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9854

    OMIM: 602362

    KEGG: hsa:5905

    STRING: 9606.ENSP00000348577

    UniGene: Hs.183800



主站蜘蛛池模板: 激情综合亚洲色婷婷五月| 国内露脸中年夫妇交换| 国产精品久久久久影院| 久久99久久99小草精品免视看| 国产精品午夜视频自在拍| 亚洲欧美日韩另类丝袜一区| 无码熟妇人妻av在线电影| 欧美国产激情18| 97成人碰碰久久人人超级碰oo| 国产乱子伦一区二区三区视频播放| 免费无码专区在线视频| 欧美牲交a欧美牲交| 天天躁日日躁狠狠躁超碰97| 天堂在线www中文| 亚洲人成黄网站69影院| 国产黄大片在线观看| 国产人妻黑人一区二区三区| 亚洲国产欧美一区点击进入 | 国产片av国语在线观麻豆| 国产真实老熟女无套内射| 伊人色综合久久天天五月婷| 久久人人97超碰爱香蕉| 亚洲国产天堂久久综合网| 青青草大香焦在线综合视频 | h人成在线看免费视频| 亚洲色一区二区三区四区| 国产精品免费观看久久| 国产成人啪精品视频免费网站软件| 国产深夜福利视频在线| 在线看亚洲十八禁网站| 国产精品高潮呻吟av久久4虎 | 日本三级带日本三级带黄| 日韩激情无码不卡码| 国产精品亚洲一区二区三区喷水 | 久久www免费人成精品| 国内精品久久久久影院老司机| 久久久橹橹橹久久久久| 无码丰满熟妇| 国产香蕉尹人在线视频你懂的 | 伊人久久丁香色婷婷啪啪| 成人国产精品一区二区免费看 |