在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RANGAP1 Antibody

  • 中文名稱:
    RANGAP1兔多克隆抗體
  • 貨號:
    CSB-PA019318GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    RANGAP1
  • 別名:
    Fug 1 antibody; Fug1 antibody; GTPase-activating protein, RAN, 1 antibody; KIAA1835 antibody; MGC20266 antibody; OTTHUMP00000028918 antibody; OTTHUMP00000198755 antibody; OTTHUMP00000198756 antibody; OTTHUMP00000198757 antibody; OTTHUMP00000198758 antibody; RAGP1_HUMAN antibody; Ran 1 antibody; RAN GTPase activating protein 1 antibody; Ran GTPase-activating protein 1 antibody; Ran1 antibody; RANGAP 1 antibody; RANGAP antibody; RanGAP1 antibody; SD antibody; Segregation distorter homolog antibody; Segregation distortion antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human RANGAP1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export. Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export.
  • 基因功能參考文獻:
    1. RanGAP1 upregulation is associated with drug resistance in Chronic Myeloid Leukemia. PMID: 27228340
    2. Abnormal localization of RanGAP1 was found in cortex of Huntington's disease patients. PMID: 28384474
    3. our results elucidate that RanGAP1 is actively transported between the nuclear and cytoplasmic compartments, and that the cytoplasmic and NPC localization of RanGAP1 is dependent on CRM1-mediated nuclear export. PMID: 26506250
    4. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 and NF-kappaB p65 nuclear entry in T cells PMID: 26321253
    5. Differentiation of human coronary artery smooth muscle cell to a contractile phenotype by stepwise serum depletion leads to significant reduction of RanGAP1 protein levels. PMID: 24988324
    6. Analysis of the dynamics of E2(Ubc9)-SUMO-Target(RanGAP1) in the absence and presence of E3(RanBP2) revealed that two different allosteric sites regulate the ligase activity. PMID: 21216249
    7. the RanGAP1 consensus sumoylation site and SUMO-1 C terminus are both conformationally flexible PMID: 15355965
    8. the 3.0-A crystal structure of a four-protein complex of Ubc9, a Nup358/RanBP2 E3 ligase domain (IR1-M) and SUMO-1 conjugated to the carboxy-terminal domain of RanGAP1 PMID: 15931224
    9. RanGAP1 is phosphorylated on Ser-358 in vivo & in vitro. Phosphorylated RanGAP1, but not a mutant at 358S, formed a stable ternary complex with Ran and RanBP1 in vivo, suggesting that its 358S phosphorylation affects the Ran system. PMID: 16428860
    10. The results of this study strengthen the conclusion that mel-18 functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RanGAP1. PMID: 18706886

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族:
    RNA1 family
  • 組織特異性:
    Highly expressed in brain, thymus and testis.
  • 數據庫鏈接:

    HGNC: 9854

    OMIM: 602362

    KEGG: hsa:5905

    STRING: 9606.ENSP00000348577

    UniGene: Hs.183800



主站蜘蛛池模板: 992tv精品视频tv在线观看| 国产伦精品一区二区三区妓女下载| 精品亚洲国产成人av在线时间短的| 2018高清日本一道国产-在| 国产高清国产精品国产专区| 少妇高潮毛片免费看| 无码人妻丰满熟妇区五十路| 8ⅹ8x擦拨擦拨成人免费视频| 极品少妇一区二区三区四区| 两个奶头被吃高潮视频| 男女性杂交内射妇女bbwxz| 欧洲无码精品a码无人区| 性亚洲videofree高清| 婷婷亚洲综合五月天小说| 人妻熟女一二三区夜夜爱| 无码人妻精品一区二区三区免费 | 亚洲日韩精品一区二区三区无码| 忘忧草日本在线www| 青椒国产97在线熟女| 免费观看的av毛片的网站| 婷婷国产成人精品视频| 亚洲欧美国产双大乳头| 国产台湾无码av片在线观看| 好了av四色综合无码| 国产伦精品一区二区三区妓女下载| 老汉色老汉首页a亚洲| 欧美大片aaaaa免费观看| 人妻少妇精品视频一区二区三区| 久久精品成人免费国产| 欧美成人性做爰77777| 久久久久久久久无码精品亚洲日韩| 都市激情 在线 亚洲 国产| 色综合天天天天综合狠狠爱| 大胸少妇午夜三级| 亚洲综合一区二区三区无码| 精品无码日韩一区二区三区不卡 | 国产丝袜视频一区二区三区| www.-级毛片线天内射视视| 少妇扒开双腿让我看个够| 日韩在线不卡免费视频一区| 国产精品交换|