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Recombinant Human RNA (guanine-9-)-methyltransferase domain-containing protein 2 (RG9MTD2)

  • 中文名稱:
    人TRMT10A重組蛋白
  • 貨號:
    CSB-YP844715HU
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人TRMT10A重組蛋白
  • 貨號:
    CSB-EP844715HU
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人TRMT10A重組蛋白
  • 貨號:
    CSB-EP844715HU-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人TRMT10A重組蛋白
  • 貨號:
    CSB-BP844715HU
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人TRMT10A重組蛋白
  • 貨號:
    CSB-MP844715HU
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    TRMT10A
  • Uniprot No.:
  • 別名:
    FLJ20325; MGC27034; OTTHUMP00000220442; OTTHUMP00000220443; RG9D2_HUMAN; RG9MTD 2; Rg9mtd2; RNA (guanine-9-) methyltransferase domain containing 2; RNA (guanine-9-)-methyltransferase domain-containing protein 2; RNA (guanine-9-)methyltransferase domain containing protein 2; TRM10
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-339
  • 氨基酸序列
    MSSEMLPAFI ETSNVDKKQG INEDQEESQK PRLGEGCEPI SKRQMKKLIK QKQWEEQREL RKQKRKEKRK RKKLERQCQM EPNSDGHDRK RVRRDVVHST LRLIIDCSFD HLMVLKDIKK LHKQIQRCYA ENRRALHPVQ FYLTSHGGQL KKNMDENDKG WVNWKDIHIK PEHYSELIKK EDLIYLTSDS PNILKELDES KAYVIGGLVD HNHHKGLTYK QASDYGINHA QLPLGNFVKM NSRKVLAVNH VFEIILEYLE TRDWQEAFFT ILPQRKGAVP TDKACESASH DNQSVRMEEG GSDSDSSEEE YSRNELDSPH EEKQDKENHT ESTVNSLPH
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs.
  • 基因功能參考文獻:
    1. A homozygous G to T transition in exon 2 of gene TRMT10A at nucleotide position 79 of the coding sequence was identified in a family with young-adult onset diabetes with intellectual disability, microcephaly and epilepsy. PMID: 26526202
    2. Homozygous deletion of TRMT10A is associated with a syndrome of failure to thrive, delayed puberty, intellectual disability and diabetes mellitus. PMID: 26297882
    3. TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly. PMID: 25053765
    4. This is the first study describing the impact of TRMT10A deficiency in mammals, highlighting a role in the pathogenesis of microcephaly and early onset diabetes. PMID: 24204302
  • 相關疾病:
    Microcephaly, short stature, and impaired glucose metabolism 1 (MSSGM1)
  • 亞細胞定位:
    Nucleus. Nucleus, nucleolus.
  • 蛋白家族:
    Class IV-like SAM-binding methyltransferase superfamily, TRM10 family
  • 組織特異性:
    Expressed in embryonic and fetal brain. It is expressed throughout the dorsal telencephalon at 8 and 11 weeks of gestation, with highest expression in ventricular zone and marginal zone. Detected in cerebellar cortex and nuclei, but not in dorsal telencep
  • 數據庫鏈接:

    HGNC: 28403

    OMIM: 616013

    KEGG: hsa:93587

    STRING: 9606.ENSP00000273962

    UniGene: Hs.380412



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