在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein unc-13 homolog A (UNC13A), partial

In Stock
  • 中文名稱:
    人UNC13A重組蛋白
  • 貨號:
    CSB-EP891983HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    UNC13A; KIAA1032; Protein unc-13 homolog A; Munc13-1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    43.2 kDa
  • 表達區域:
    1-340aa
  • 氨基酸序列
    MSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGLTVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQVIMADSEICGTKDPTFHRILLDTRFELPLDIPEEEARYWAKKLEQLNAMRDQDEYSFQDEQDKPLPVPSNQCCNWNYFGWGEQHNDDPDSAVDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSVRPPPLGSRESYSDSMHSYEEFSEPQALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSDMEDERDRDSYHSCHSSVSYHKDSPRWDQDEEELEEDLEDFLEEEELPED
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release. Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes.
  • 基因功能參考文獻:
    1. This study demonstrated that the population specific rare variants of UNC13A may modulate survival in ALS in United kingdom. PMID: 27584932
    2. Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder PMID: 28192369
    3. UNC13A rs12608932 is a risk factor for ALS and a modifying factor for survival and disease progression rate in a Spanish cohort. PMID: 26162714
    4. Munc13-1, on account of its role in both insulin and neurotransmitter exocytosis and through its binding properties, may be an important factor contributing to the development or progression of diabetic neuropathy. PMID: 23830992
    5. UNC13A provides a novel link between amyotrophic lateral sclerosis and frontotemporal dementia and identifies changes in neurotransmitter release and synaptic function as a converging mechanism in the pathogenesis of ALS and FTD-TDP. PMID: 24931836
    6. CAPS1 binds to the full-length of cytoplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1. PMID: 23801330
    7. This study demonistrated that UNC13A influences survival in Italian amyotrophic lateral sclerosis patients. PMID: 22921269
    8. Our results further corroborate the role of UNC13A in amyotrophic lateral sclerosis pathogenesis. PMID: 22118904
    9. Results do not provide evidence of an association between a variant in the UNC13A gene and susceptibility to sporadic Amyotrophic lateral sclerosis in a French homogeneous population. PMID: 20385924
    10. rs12608932 Single Nucleotide Polymorphism is located at 19p13.3 and maps to a haplotype block within the boundaries of UNC13A, which regulates the release of neurotransmitters such as glutamate at neuromuscular synapses. PMID: 19734901

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic active zone.
  • 蛋白家族:
    Unc-13 family
  • 組織特異性:
    Expressed in pancreatic islet cells. Expressed in melanocytes.
  • 數據庫鏈接:

    HGNC: 23150

    OMIM: 609894

    KEGG: hsa:23025

    STRING: 9606.ENSP00000429562

    UniGene: Hs.164502



主站蜘蛛池模板: 另类亚洲综合区图片区小说| 成 人片 黄 色 大 片| 熟女少妇内射日韩亚洲| 亚洲国产一区二区三区在观看| 99精品国产丝袜在线拍国语| 国产午夜永久福利视频在线观看 | 亚洲国产精华液网站w| 美女国产毛片a区内射| 国产亚洲产品影视在线产品| 亚洲日本va中文字幕人妖 | 精品人妻午夜一区二区三区四区| 国模大尺度啪啪| 亚洲日韩欧美国产另类综合| 国产99爱在线视频免费观看| 久久天天躁狠狠躁夜夜avapp| 成人免费无遮挡无码黄漫视频| 国产成人精品无码一区二区三区| 欧美肥老太交性506070| 久久躁狠狠躁夜夜av| 永久免费的无码中文字幕| 成人精品一区二区三区电影免费| 在线精品亚洲一区二区| 牲交欧美兽交欧美| 三叶草欧洲码在线| 成年美女黄的视频网站| 中文字幕精品亚洲人成在线| 精品免费国产一区二区三区四区 | 色香阁综合无码国产在线| 少妇人妻大乳在线视频| 亚洲国产aⅴ成人精品无吗 | 中文字幕无码无码专区| 中文字幕无线码一区2020青青| 亚洲欧美日韩综合久久| 玩弄放荡人妻少妇系列| 男人靠女人免费视频网站| 色喜国模李晴超大尺度| 国产精华av午夜在线观看| 人妻夜夜添夜夜无码av| 熟妇熟女乱妇乱女网站| 天天摸天天做天天添欧美| 99久久久精品免费观看国产|