在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Protein prune homolog 2 (PRUNE2), partial

Recombinant Human Protein prune homolog 2 (PRUNE2), partial

  • 中文名稱：
    人PRUNE2重組蛋白
  • 貨號：
    CSB-YP848821HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PRUNE2重組蛋白
  • 貨號：
    CSB-EP848821HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PRUNE2重組蛋白
  • 貨號：
    CSB-EP848821HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PRUNE2重組蛋白
  • 貨號：
    CSB-BP848821HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PRUNE2重組蛋白
  • 貨號：
    CSB-MP848821HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PRUNE2
  • Uniprot No.：
  • 別名：
    PRUNE2; BMCC1; BNIPXL; C9orf65; KIAA0367; Protein prune homolog 2; BNIP2 motif-containing molecule at the C-terminal region 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.
  • 基因功能參考文獻：
    1. E2F1 directly facilitated BMCC1 transcription. These results also suggest that BMCC1 induced by E2F1 acts as a tumor suppressor through its pro-apoptotic function, resulted in favorable prognosis of neuroblastoma. PMID: 27453342
    2. Results show prostate cancer antigen 3 (PCA3) as a dominant-negative oncogene and PRUNE2 protein as an unrecognized tumor suppressor gene in prostate cancer. PMID: 26080435
    3. BMCC1 negatively regulates phosphorylation pathway of AKT, resulted in apoptosis and the BNIP2 homology region of BMCC1 interacts with BCL2. PMID: 25611382
    4. recurrent germ line and somatic mutations in PRUNE2 were found in parathyroid carcinoma and computationally predicted to be deleterious; in addition, recurrent mutations in kinase genes related to cell migration and invasion were found. PMID: 25387265
    5. BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells. PMID: 24040105
    6. We showed that Olfaxin, a novel Prune2 isoform contains a BCH motif and localizes predominantly to the synaptic cytosol in the olfactory bulb and layer Ia of the piriform cortex. PMID: 23059019
    7. PRUNE2 expression is correlated with the survival of leiomyosarcoma patients. Non-coding RNA PCA3 has a significant positive correlation with PRUNE2 and may play an important role in the pathogenesis of leiomyosarcoma. PMID: 22967466
    8. The nerve tissue-specific and post-development expression of PRUNE2/Prune2 suggests that PRUNE2 may contribute to the maintenance of mature nervous systems. PMID: 21234814
    9. BMCC1 is a new member of prognostic factors for NBL and may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells PMID: 16288218
    10. Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities. PMID: 17961507
    11. findings show the BNIP2 & BCH domain of BNIPXL interacts with specific conformers of RhoA & mediates association with catalytic DH-PH domains of Lbc, a RhoA-specific guanine nucleotide exchange factor; BNIPXL inhibits Lbc-induced oncogenic transformation PMID: 18445682
    12. the longer BMCC1-1 isoform is upregulated in PCa tissues and metastases PMID: 19319183
    13. The androgen regulation of PRUNE2 expression in prostate cancer cells was found to not be of any diagnostic value. PMID: 19760627

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    PPase class C family, Prune subfamily
  • 組織特異性：
    A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in can
  • 數據庫鏈接：

    HGNC: 25209

    OMIM: 610691

    KEGG: hsa:158471

    STRING: 9606.ENSP00000365908

    UniGene: Hs.262857



主站蜘蛛池模板： 亚洲欧美综合精品成人网| 胸大美女又黄的网站| 国产成人免费爽爽爽视频| 中文字幕一区二区人妻电影| 国产视频亚洲精品视频| 日韩亚洲国产高清免费视频| 亚洲日韩久久综合中文字幕| 国产精品免费观看久久| 午夜私人成年影院| 色噜噜狠狠色综合网| 天天爱天天做久久狼狼| 丰满人妻精品国产99aⅴ| 人人妻人人爽人人做夜欢视频| 四虎永久在线精品免费网址| 影音先锋无码a∨男人资源站| 人妻无码专区一区二区三区| 乱人伦人妻精品一区二区| 性欧美老人牲交xxxxx视频| 久久成人国产精品免费| 久久99精品久久久久久2021| 免费网站观看www在线观看| 久久久久无码国产精品不卡| 国产人妻黑人一区二区三区| 久天啪天天久久99久久| 人妻三级日本三级日本三级极| av无码av天天av天天爽| 中国大陆高清aⅴ毛片| 久久香蕉综合色一综合色88| 麻豆人妻无码性色av专区 | 色哟哟精品视频在线观看| 色婷婷综合激情综在线播放 | 色欲aⅴ 无码| 啦啦啦www播放日本观看| 成人免费视频在线观看| 国产av福利久久| 中文字幕有码无码av| 无码人妻久久久一区二区三区| 亚洲人成小说网站色在线| 熟女少妇人妻黑人sirbao| 久久人妻夜夜做天天爽| 狠狠色噜噜狠狠狠8888米奇|