在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRUNE2 Antibody

  • 中文名稱:
    PRUNE2兔多克隆抗體
  • 貨號:
    CSB-PA848821DSR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA848821DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA848821DSR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PRUNE2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PRUNE2
  • 別名:
    PRUNE2 antibody; BMCC1 antibody; BNIPXL antibody; C9orf65 antibody; KIAA0367 antibody; Protein prune homolog 2 antibody; BNIP2 motif-containing molecule at the C-terminal region 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein prune homolog 2 protein (1-250AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.
  • 基因功能參考文獻:
    1. E2F1 directly facilitated BMCC1 transcription. These results also suggest that BMCC1 induced by E2F1 acts as a tumor suppressor through its pro-apoptotic function, resulted in favorable prognosis of neuroblastoma. PMID: 27453342
    2. Results show prostate cancer antigen 3 (PCA3) as a dominant-negative oncogene and PRUNE2 protein as an unrecognized tumor suppressor gene in prostate cancer. PMID: 26080435
    3. BMCC1 negatively regulates phosphorylation pathway of AKT, resulted in apoptosis and the BNIP2 homology region of BMCC1 interacts with BCL2. PMID: 25611382
    4. recurrent germ line and somatic mutations in PRUNE2 were found in parathyroid carcinoma and computationally predicted to be deleterious; in addition, recurrent mutations in kinase genes related to cell migration and invasion were found. PMID: 25387265
    5. BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells. PMID: 24040105
    6. We showed that Olfaxin, a novel Prune2 isoform contains a BCH motif and localizes predominantly to the synaptic cytosol in the olfactory bulb and layer Ia of the piriform cortex. PMID: 23059019
    7. PRUNE2 expression is correlated with the survival of leiomyosarcoma patients. Non-coding RNA PCA3 has a significant positive correlation with PRUNE2 and may play an important role in the pathogenesis of leiomyosarcoma. PMID: 22967466
    8. The nerve tissue-specific and post-development expression of PRUNE2/Prune2 suggests that PRUNE2 may contribute to the maintenance of mature nervous systems. PMID: 21234814
    9. BMCC1 is a new member of prognostic factors for NBL and may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells PMID: 16288218
    10. Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities. PMID: 17961507
    11. findings show the BNIP2 & BCH domain of BNIPXL interacts with specific conformers of RhoA & mediates association with catalytic DH-PH domains of Lbc, a RhoA-specific guanine nucleotide exchange factor; BNIPXL inhibits Lbc-induced oncogenic transformation PMID: 18445682
    12. the longer BMCC1-1 isoform is upregulated in PCa tissues and metastases PMID: 19319183
    13. The androgen regulation of PRUNE2 expression in prostate cancer cells was found to not be of any diagnostic value. PMID: 19760627

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    PPase class C family, Prune subfamily
  • 組織特異性:
    A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in can
  • 數據庫鏈接:

    HGNC: 25209

    OMIM: 610691

    KEGG: hsa:158471

    STRING: 9606.ENSP00000365908

    UniGene: Hs.262857



主站蜘蛛池模板: 亚洲最大av无码国产| 女人爽到高潮潮喷18禁网站| 成人亚洲精品久久久久| 欧美老妇bbbwwbbbww| 久久久无码精品午夜| 免费国产白丝喷水娇喘视频| 少妇人妻中文字幕hd| 中本亚洲欧美国产日韩| 国产日产欧美最新| 偷国产乱人伦偷精品视频| 精品久久久无码人妻中文字幕 | 中文字幕人妻被公上司喝醉| 性xxx欧美老妇5060.70| 亚洲欧美日韩另类精品一区| 国产免费又黄又爽又色毛| 一本大道伊人av久久乱码| 国产区女主播在线观看| а√天堂8资源中文在线| 伊人久久大香线蕉在观看| 69风韵老熟女口爆吞精| 久久精品99久久香蕉国产| 国产一区日韩二区欧美三区| 夜夜夜夜曰天天天天拍国产| 伊人色综合久久天天| 日韩精品无码免费专区网站| 麻婆豆传媒一区二区三区| 亚洲国产码专区| 亚洲性夜色噜噜噜网站2258kk| 十八禁裸体www网站免费观看| 麻豆国产尤物av尤物在线观看| 韩国19禁主播深夜福利视频| 欧美自拍亚洲综合图区| 无码h黄肉3d动漫在线观看| 无码人妻一区二区三区一| 欧洲亚洲1卡二卡三卡2021| 国产福利酱国产一区二区| 国色天香社区视频| 妺妺窝人体色www婷婷| 少妇高潮无套内谢| 2018高清日本一道国产-在| 极品少妇被猛的白浆直喷白浆|