在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRUNE2 Antibody

  • 中文名稱:
    PRUNE2兔多克隆抗體
  • 貨號:
    CSB-PA848821DSR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA848821DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA848821DSR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PRUNE2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PRUNE2
  • 別名:
    PRUNE2 antibody; BMCC1 antibody; BNIPXL antibody; C9orf65 antibody; KIAA0367 antibody; Protein prune homolog 2 antibody; BNIP2 motif-containing molecule at the C-terminal region 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein prune homolog 2 protein (1-250AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.
  • 基因功能參考文獻:
    1. E2F1 directly facilitated BMCC1 transcription. These results also suggest that BMCC1 induced by E2F1 acts as a tumor suppressor through its pro-apoptotic function, resulted in favorable prognosis of neuroblastoma. PMID: 27453342
    2. Results show prostate cancer antigen 3 (PCA3) as a dominant-negative oncogene and PRUNE2 protein as an unrecognized tumor suppressor gene in prostate cancer. PMID: 26080435
    3. BMCC1 negatively regulates phosphorylation pathway of AKT, resulted in apoptosis and the BNIP2 homology region of BMCC1 interacts with BCL2. PMID: 25611382
    4. recurrent germ line and somatic mutations in PRUNE2 were found in parathyroid carcinoma and computationally predicted to be deleterious; in addition, recurrent mutations in kinase genes related to cell migration and invasion were found. PMID: 25387265
    5. BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells. PMID: 24040105
    6. We showed that Olfaxin, a novel Prune2 isoform contains a BCH motif and localizes predominantly to the synaptic cytosol in the olfactory bulb and layer Ia of the piriform cortex. PMID: 23059019
    7. PRUNE2 expression is correlated with the survival of leiomyosarcoma patients. Non-coding RNA PCA3 has a significant positive correlation with PRUNE2 and may play an important role in the pathogenesis of leiomyosarcoma. PMID: 22967466
    8. The nerve tissue-specific and post-development expression of PRUNE2/Prune2 suggests that PRUNE2 may contribute to the maintenance of mature nervous systems. PMID: 21234814
    9. BMCC1 is a new member of prognostic factors for NBL and may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells PMID: 16288218
    10. Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities. PMID: 17961507
    11. findings show the BNIP2 & BCH domain of BNIPXL interacts with specific conformers of RhoA & mediates association with catalytic DH-PH domains of Lbc, a RhoA-specific guanine nucleotide exchange factor; BNIPXL inhibits Lbc-induced oncogenic transformation PMID: 18445682
    12. the longer BMCC1-1 isoform is upregulated in PCa tissues and metastases PMID: 19319183
    13. The androgen regulation of PRUNE2 expression in prostate cancer cells was found to not be of any diagnostic value. PMID: 19760627

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    PPase class C family, Prune subfamily
  • 組織特異性:
    A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in can
  • 數據庫鏈接:

    HGNC: 25209

    OMIM: 610691

    KEGG: hsa:158471

    STRING: 9606.ENSP00000365908

    UniGene: Hs.262857



主站蜘蛛池模板: 成年女人a毛片免费视频| 久久国产精品久久久久久| 日韩精品一区二区三区在线观看| 给我免费的视频在线观看| 韩国无码av片在线观看| 西欧free性满足hd| 插b内射18免费视频| 无码人妻丰满熟妇区五十路百度| 无码av一区二区大桥久未| 久久不见久久见免费影院视频| 国产裸体美女永久免费无遮挡| 大肉大捧一进一出视频| 大学生被内谢粉嫩无套| 久久久久久综合岛国免费观看| 免费无码一区二区三区a片百度| 国产精品久久久天天影视| 国产精品高清一区二区不卡片| 亚洲欧洲日本综合aⅴ在线| 少妇高潮毛片免费看| 国产精品不卡无码av在线播放 | 真正免费毛片在线播放| 亚洲亚洲人成网站网址| 丰满少妇高潮惨叫久久久一| 无码一区二区三区av免费蜜桃| 久久99热只有频精品8| 日本亚洲色大成网站www久久| 久久久久有精品国产麻豆| 老司机免费的精品视频| 婷婷五月综合色中文字幕| 一本大道东京热无码aⅴ| 久久伊人精品波多野结衣| 日本少妇浓毛bbwbbwbbw| 成人影院yy111111在线观看| 国模欢欢炮交啪啪150| 国产沙发午睡系列999| 国产精品久久久久久熟妇吹潮软件 | 又色又爽又黄的gif动态图| 伊人久久大香线蕉综合狠狠| 成人片黄网站色大片免费毛片| 国产又猛又黄又爽| 国产美女久久精品香蕉|