在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Protein-methionine sulfoxide oxidase MICAL1 (MICAL1), partial

Recombinant Human Protein-methionine sulfoxide oxidase MICAL1 (MICAL1), partial

  • 中文名稱：
    人MICAL1重組蛋白
  • 貨號：
    CSB-YP851555HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MICAL1重組蛋白
  • 貨號：
    CSB-EP851555HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MICAL1重組蛋白
  • 貨號：
    CSB-EP851555HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MICAL1重組蛋白
  • 貨號：
    CSB-BP851555HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MICAL1重組蛋白
  • 貨號：
    CSB-MP851555HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MICAL1
  • Uniprot No.：
  • 別名：
    CasL interacting molecule; DKFZp434B1517; FLJ11937; FLJ21739; MICA1_HUMAN; MICAL 1; MICAL; MICAL1; microtubule associated monoxygenase; calponin and LIM domain containing 1; Molecule interacting with CasL protein 1; NEDD9 interacting protein with calponin homology and LIM domains; NEDD9-interacting protein with calponin homology and LIM domains; NICAL; OTTHUMP00000016969
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking.
  • 基因功能參考文獻：
    1. Methionine oxidation is regulated in vivo by monooxygenases of the MICAL family. (Review) PMID: 28229915
    2. describe methods to characterize MICAL-mediated F-actin disassembly using in vitro assays with purified proteins PMID: 27787846
    3. The results provide evidence that MICAL1 plays an essential role in the activation of ROS/Akt signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 in regulating breast cancer cell invasion. PMID: 27430308
    4. The MICAL1 directly induce oxidation of actin molecules, leading to actin depolymerization. ROS production by MICAL1 also causes oxidation of collapsin response mediator protein-2 which subsequently undergoes phosphorylation. PMID: 23834433
    5. although MICAL1 is auto-inhibited by its C-terminal coiled-coil region, MICAL2 remains constitutively active and affects stress fibers, suggesting differential but complementary roles for MICAL1 and MICAL2 in actin microfilament regulation PMID: 22331357
    6. Faint and scattered immunoreactivity for Mical-1 is observed in neurons of the neocortex of the temporal lobe epilepsy group, while strong immunoreactivity for Mical-1 is shown in control subjects. PMID: 21638339
    7. Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling. PMID: 21730291
    8. a CasL interacting molecule that associates with vimentin PMID: 11827972
    9. MICAL-1 isoforms with their multidomain structure are novel rab1 interacting proteins that function as scaffold proteins connecting different components in the cell. PMID: 12788069
    10. The unfolding of MICAL-1 calpolnin homology (CH) domain was studied. PMID: 17662518

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Midbody.
  • 蛋白家族：
    Mical family
  • 組織特異性：
    Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.
  • 數據庫鏈接：

    HGNC: 20619

    OMIM: 607129

    KEGG: hsa:64780

    STRING: 9606.ENSP00000351664

    UniGene: Hs.33476



主站蜘蛛池模板： 国产99久久亚洲综合精品西瓜tv| 亚洲一区二区三区写真| 亚洲精品午夜无码专区| 天天爽亚洲中文字幕| 亚洲欧美国产va在线播放| 久久久久久av无码免费看大片 | 亚洲精品国产自在现线看| 无码乱肉视频免费大全合集| 中国无码人妻丰满熟妇啪啪软件| 50岁退休熟女露脸高潮| 国产精品主播一区二区三区| 国产精品人成视频免费国产| 狠狠人妻久久久久久综合蜜桃 | 亚洲va中文字幕无码久久不卡| 精品国产av一区二区三区| 亚洲伊人色欲综合网| 日本熟妇浓密毛毛多| 久久www色情成人免费观看| 国产精品视频| 妇女性内射冈站hdwww000| 亚洲性夜夜天天天| 天天躁日日躁狠狠躁人妻 | 青草草在线视频永久免费| 双腿张开被9个黑人调教影片| 秋霞无码久久久精品交换| 在线观看特色大片免费视频| h肉动漫无码无修6080动漫网 | 2021少妇久久久久久久久久| 无码视频在线观看| 国产成人精品无码片区在线观看| 国产亚洲福利在线视频| 国产亚洲精品a片久久久| 人妻丰满av无码久久不卡| 天天综合亚洲色在线精品| 高潮好爽视频在线观看| 人妻饥渴偷公乱中文字幕| 又黄又爽又色的视频| 亚洲不卡一卡2卡三卡4卡5卡| 一区二区国产高清视频在线| 国产精品卡一卡二卡三| 东京热加勒比视频一区|