在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MICAL1 Antibody, Biotin conjugated

MICAL1 Antibody, Biotin conjugated

  • 中文名稱：
    MICAL1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA851555LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MICAL1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MICAL1
  • 別名：
    CasL interacting molecule antibody; DKFZp434B1517 antibody; FLJ11937 antibody; FLJ21739 antibody; MICA1_HUMAN antibody; MICAL 1 antibody; MICAL antibody; MICAL1 antibody; microtubule associated monoxygenase; calponin and LIM domain containing 1 antibody; Molecule interacting with CasL protein 1 antibody; NEDD9 interacting protein with calponin homology and LIM domains antibody; NEDD9-interacting protein with calponin homology and LIM domains antibody; NICAL antibody; OTTHUMP00000016969 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human [F-actin]-methionine sulfoxide oxidase MICAL1 protein (806-1067AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking.
  • 基因功能參考文獻：
    1. Methionine oxidation is regulated in vivo by monooxygenases of the MICAL family. (Review) PMID: 28229915
    2. describe methods to characterize MICAL-mediated F-actin disassembly using in vitro assays with purified proteins PMID: 27787846
    3. The results provide evidence that MICAL1 plays an essential role in the activation of ROS/Akt signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 in regulating breast cancer cell invasion. PMID: 27430308
    4. The MICAL1 directly induce oxidation of actin molecules, leading to actin depolymerization. ROS production by MICAL1 also causes oxidation of collapsin response mediator protein-2 which subsequently undergoes phosphorylation. PMID: 23834433
    5. although MICAL1 is auto-inhibited by its C-terminal coiled-coil region, MICAL2 remains constitutively active and affects stress fibers, suggesting differential but complementary roles for MICAL1 and MICAL2 in actin microfilament regulation PMID: 22331357
    6. Faint and scattered immunoreactivity for Mical-1 is observed in neurons of the neocortex of the temporal lobe epilepsy group, while strong immunoreactivity for Mical-1 is shown in control subjects. PMID: 21638339
    7. Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling. PMID: 21730291
    8. a CasL interacting molecule that associates with vimentin PMID: 11827972
    9. MICAL-1 isoforms with their multidomain structure are novel rab1 interacting proteins that function as scaffold proteins connecting different components in the cell. PMID: 12788069
    10. The unfolding of MICAL-1 calpolnin homology (CH) domain was studied. PMID: 17662518

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Midbody.
  • 蛋白家族：
    Mical family
  • 組織特異性：
    Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.
  • 數據庫鏈接：

    HGNC: 20619

    OMIM: 607129

    KEGG: hsa:64780

    STRING: 9606.ENSP00000351664

    UniGene: Hs.33476



主站蜘蛛池模板： 国产精品亚亚洲欧关中字幕| 国产嘿嘿嘿视频在线观看| 四虎永久在线精品免费视频观看 | 在线播放十八禁视频无遮挡| 亚州性无码不卡免费视频| 国产做a爰片久久毛片a片| 狠狠躁夜夜躁人人爽天天天天97| 欧美私人情侣网站| 亚洲va在线va天堂xxxx中文| 国产精品亚洲玖玖玖在线观看| 欧洲精品卡一卡二卡三| 超碰国产精品久久国产精品99| 丰满爆乳无码一区二区三区| 亚洲香蕉视频天天爽| 亚洲婷婷五月激情综合app| 亚洲国产成人无码电影| 成年午夜无码av片在线观看| 亚洲伊人久久综合影院| 色五月丁香五月综合五月4438| 永久免费观看的毛片手机视频| 特级小箩利无码毛片| 精品人妻va出轨中文字幕| 久久久日韩精品一区二区 | 成人无码a∨电影免费| 无码国产精品一区二区色情男同| 亚洲男同志网站| 色综合视频一区中文字幕| 中文资源在线天堂库8| 国产女女做受ⅹxx高潮| 色综合久久无码中文字幕| 久久精品成人免费观看三| 国产无遮挡a片又黄又爽漫画| 伊人久久大香线蕉av五月天宝贝| 国产h视频在线观看| 国内无遮挡18禁无码网站免费| 玩50岁四川熟女大白屁股直播| 内射白浆一区二区在线观看 | 国产成人综合色就色综合| 精精国产xxxx视频在线播放| 日韩av无码国产精品| 100禁毛片免费40分钟视频|