在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MICAL1 Antibody

MICAL1 Antibody

  • 中文名稱：
    MICAL1兔多克隆抗體
  • 貨號：
    CSB-PA013807GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MICAL1
  • 別名：
    CasL interacting molecule antibody; DKFZp434B1517 antibody; FLJ11937 antibody; FLJ21739 antibody; MICA1_HUMAN antibody; MICAL 1 antibody; MICAL antibody; MICAL1 antibody; microtubule associated monoxygenase; calponin and LIM domain containing 1 antibody; Molecule interacting with CasL protein 1 antibody; NEDD9 interacting protein with calponin homology and LIM domains antibody; NEDD9-interacting protein with calponin homology and LIM domains antibody; NICAL antibody; OTTHUMP00000016969 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Human MICAL1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IP
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking.
  • 基因功能參考文獻：
    1. Methionine oxidation is regulated in vivo by monooxygenases of the MICAL family. (Review) PMID: 28229915
    2. describe methods to characterize MICAL-mediated F-actin disassembly using in vitro assays with purified proteins PMID: 27787846
    3. The results provide evidence that MICAL1 plays an essential role in the activation of ROS/Akt signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 in regulating breast cancer cell invasion. PMID: 27430308
    4. The MICAL1 directly induce oxidation of actin molecules, leading to actin depolymerization. ROS production by MICAL1 also causes oxidation of collapsin response mediator protein-2 which subsequently undergoes phosphorylation. PMID: 23834433
    5. although MICAL1 is auto-inhibited by its C-terminal coiled-coil region, MICAL2 remains constitutively active and affects stress fibers, suggesting differential but complementary roles for MICAL1 and MICAL2 in actin microfilament regulation PMID: 22331357
    6. Faint and scattered immunoreactivity for Mical-1 is observed in neurons of the neocortex of the temporal lobe epilepsy group, while strong immunoreactivity for Mical-1 is shown in control subjects. PMID: 21638339
    7. Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling. PMID: 21730291
    8. a CasL interacting molecule that associates with vimentin PMID: 11827972
    9. MICAL-1 isoforms with their multidomain structure are novel rab1 interacting proteins that function as scaffold proteins connecting different components in the cell. PMID: 12788069
    10. The unfolding of MICAL-1 calpolnin homology (CH) domain was studied. PMID: 17662518

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Midbody.
  • 蛋白家族：
    Mical family
  • 組織特異性：
    Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.
  • 數據庫鏈接：

    HGNC: 20619

    OMIM: 607129

    KEGG: hsa:64780

    STRING: 9606.ENSP00000351664

    UniGene: Hs.33476



主站蜘蛛池模板： 亚洲精品成人福利网站| 久久精品国产曰本波多野结衣| 色妺妺av爽爽影院| 爆乳一区二区三区无码| 欧美人与zoxxxx另类| 怡红院av亚洲一区二区三区h| 欧美人与性囗牲恔配| 大香伊蕉在人线国产免费| 国产蝌蚪视频一区二区三区| 特黄做受又大又粗又长大片| 99久久99视频只有精品| 美女内射毛片在线看3d| 国产成人av在线影院| 国产精品有码无码av在线播放 | 国产精品无码免费播放| 亚洲欧洲精品无码av| 午夜精品久久久久久中宇| 国产白浆喷水在线视频| 无码中文av波多野结衣一区| 久久精品66免费99精品| 国内精品视频一区二区三区 | 777yyy亚洲精品久久久| 国产免费人成在线视频app| 国产精品久久久久影院色 | 亚洲日韩va在线视频| 国产精品亚洲а∨天堂123| 国产露脸无套对白在线播放| 亚洲中文无码a∨在线观看| 97在线成人国产在线视频 | 大学生高潮无套内谢视频| 永久免费观看黄网视频| 国产高清av喷水白丝护士| 国产在线精品一区二区中文| 日韩国产丝袜人妻一二区| 国语自产免费精品视频在| 色欲aⅴ 无码| 久久综合狠狠综合久久综合88 | 5858s亚洲色大成网站www| 国产无线乱码一区二三区| 国产ktv交换配乱婬视频| 欧美乱大交xxxxx疯狂俱乐部 |