Recombinant Human Protein jagged-2 (JAG2)

中文名稱：
貨號：

CSB-YP2785HU
規格：
來源：

Yeast
其他：

中文名稱：
貨號：

CSB-EP2785HU
規格：
來源：

E.coli
其他：

中文名稱：
貨號：

CSB-EP2785HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：
貨號：

CSB-BP2785HU
規格：
來源：

Baculovirus
其他：

中文名稱：
貨號：

CSB-MP2785HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

JAG2
Uniprot No.：

Q9Y219
別名：

Protein jagged-2; Jagged2; hJ2; JAG2
種屬：

Homo sapiens (Human)
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development.
基因功能參考文獻：
1. In CL+/-P Malay patients, the prevalence of mutations in the Jagged2 gene was 12.5%. Three variants (g.19779C>T, g.19547G>A, and g.19712C>T) were identified in the Jagged2 gene among nonsyndromic CL+/-P and noncleft patients. Only g.19712C>T showed a significant association with nonsyndromic CL+/-P patients (P = .039). PMID: 26151095
2. these results show that the Notch signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 or Jagged 2 on DCs is not required PMID: 28111308
3. The authors present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2, together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch binding is likely to be critical in establishing the optimal context for Notch signalling. PMID: 28572448
4. Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1 PMID: 22691042
5. Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells PMID: 26412454
6. Increased expression of JAG2, a target of miR-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in medulloblastoma. PMID: 25576913
7. Results show that tumor cell migration, invasion, and metastasis are dependent on JAGGED2 independently of NOTCH activation. PMID: 25351917
8. silencing prevents Notch2-driven osteoclast development and bone destruction in multiple myeloma PMID: 25257302
9. Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1. PMID: 24907271
10. This study demonistrated that NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma. PMID: 24708907
11. Jagged2 expression status was closely correlated with important histopathologic characteristics (grades and stages) and the recurrence and metastasis of bladder urothelial carcinomas. PMID: 24228105
12. Notch-1 and Jagged-2 are not expressed in spastic colon segments, which may be associated with the pathogenesis of Hirschsprung disease. PMID: 22030773
13. JAG2-mediated Notch activation confers phenotypic and functional aspects of Langerhans cell histiocytosis to dendritic cells. PMID: 23074278
14. JAG2 is often expressed by CD138(+) primary cells. Our results indicate that spontaneous clonogenic growth of myeloma cells requires the expression of JAG2. PMID: 22341562
15. This study is the first illustration of Notch-1 and Jagged-2 expression in human tissues from non-cancerous disease. PMID: 21892607
16. hypoxia-induced Jagged2 activation in both tumor invasive front and normal bone stroma has a critical role in tumor progression and metastasis PMID: 21499308
17. The stromal cell-mediated antiapoptotic effect on B- ALL cells is mediated by Notch-3 and -4 or Jagged-1/-2 and DLL-1 in a synergistic manner. PMID: 21602525
18. hypoxic induction of JAG2 in tumor cells mediates a hypoxia-regulated cross-talk between tumor and endothelial cells. PMID: 21402725
19. we have investigated their influence on early human hematopoiesis and show that Jagged2 affects hematopoietic lineage decisions very similarly as Delta-like-1 and -4, but very different from Jagged1 PMID: 21372153
20. Expression of Notch3 and Jagged2 were highly correlated in tongue carcinoma tissues. PMID: 20819128
21. Notch signaling may participate in controlling cell differentiation and proliferation in normal bone and COF of the jaws. Notch signaling disorder may be a molecular incident in COF occurrence and development. PMID: 20040020
22. JAG2 is a direct Myc target and Jagged2 and Notch signaling participate in P493-6 lymphomagenesis. PMID: 20133585
23. expression required for spermatogenesis in humans and rats PMID: 11700865
24. JAG2 was found to be overexpressed in malignant plasma cells from MM patients; coculture assay demonstrated that JAG2 induced the secretion of IL-6, VEGF, and IGF-1 in stromal cells; JAG2 overexpression may be an early event in the pathogenesis of MM PMID: 15292061
25. The upregulation of Jagged2 expression on BMEC was observed upon TNF-alpha activation. Similarly,activation of endothelial cells in Tie2-tmTNF-alpha mice was characterized by increased expression of Jagged2. PMID: 18439488
26. Results indicate JAG2 may be involved in non-syndromic cleft lip with or without cleft palate etiology in different populations. PMID: 19049519
27. SMRT function restoration induces JAG2 down-regulation as well as multipe myeloma apoptosis. PMID: 19417136
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney.
數據庫鏈接：

HGNC: 6189

OMIM: 602570

KEGG: hsa:3714

STRING: 9606.ENSP00000328169

UniGene: Hs.433445