在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

JAG2 Antibody

  • 中文名稱(chēng):
    JAG2兔多克隆抗體
  • 貨號(hào):
    CSB-PA049990
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA049990(JAG2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA049990(JAG2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    JAG2 antibody; Protein jagged-2 antibody; Jagged2 antibody; hJ2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human JAG2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development.
  • 基因功能參考文獻(xiàn):
    1. In CL+/-P Malay patients, the prevalence of mutations in the Jagged2 gene was 12.5%. Three variants (g.19779C>T, g.19547G>A, and g.19712C>T) were identified in the Jagged2 gene among nonsyndromic CL+/-P and noncleft patients. Only g.19712C>T showed a significant association with nonsyndromic CL+/-P patients (P = .039). PMID: 26151095
    2. these results show that the Notch signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 or Jagged 2 on DCs is not required PMID: 28111308
    3. The authors present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2, together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch binding is likely to be critical in establishing the optimal context for Notch signalling. PMID: 28572448
    4. Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1 PMID: 22691042
    5. Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells PMID: 26412454
    6. Increased expression of JAG2, a target of miR-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in medulloblastoma. PMID: 25576913
    7. Results show that tumor cell migration, invasion, and metastasis are dependent on JAGGED2 independently of NOTCH activation. PMID: 25351917
    8. silencing prevents Notch2-driven osteoclast development and bone destruction in multiple myeloma PMID: 25257302
    9. Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1. PMID: 24907271
    10. This study demonistrated that NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma. PMID: 24708907
    11. Jagged2 expression status was closely correlated with important histopathologic characteristics (grades and stages) and the recurrence and metastasis of bladder urothelial carcinomas. PMID: 24228105
    12. Notch-1 and Jagged-2 are not expressed in spastic colon segments, which may be associated with the pathogenesis of Hirschsprung disease. PMID: 22030773
    13. JAG2-mediated Notch activation confers phenotypic and functional aspects of Langerhans cell histiocytosis to dendritic cells. PMID: 23074278
    14. JAG2 is often expressed by CD138(+) primary cells. Our results indicate that spontaneous clonogenic growth of myeloma cells requires the expression of JAG2. PMID: 22341562
    15. This study is the first illustration of Notch-1 and Jagged-2 expression in human tissues from non-cancerous disease. PMID: 21892607
    16. hypoxia-induced Jagged2 activation in both tumor invasive front and normal bone stroma has a critical role in tumor progression and metastasis PMID: 21499308
    17. The stromal cell-mediated antiapoptotic effect on B- ALL cells is mediated by Notch-3 and -4 or Jagged-1/-2 and DLL-1 in a synergistic manner. PMID: 21602525
    18. hypoxic induction of JAG2 in tumor cells mediates a hypoxia-regulated cross-talk between tumor and endothelial cells. PMID: 21402725
    19. we have investigated their influence on early human hematopoiesis and show that Jagged2 affects hematopoietic lineage decisions very similarly as Delta-like-1 and -4, but very different from Jagged1 PMID: 21372153
    20. Expression of Notch3 and Jagged2 were highly correlated in tongue carcinoma tissues. PMID: 20819128
    21. Notch signaling may participate in controlling cell differentiation and proliferation in normal bone and COF of the jaws. Notch signaling disorder may be a molecular incident in COF occurrence and development. PMID: 20040020
    22. JAG2 is a direct Myc target and Jagged2 and Notch signaling participate in P493-6 lymphomagenesis. PMID: 20133585
    23. expression required for spermatogenesis in humans and rats PMID: 11700865
    24. JAG2 was found to be overexpressed in malignant plasma cells from MM patients; coculture assay demonstrated that JAG2 induced the secretion of IL-6, VEGF, and IGF-1 in stromal cells; JAG2 overexpression may be an early event in the pathogenesis of MM PMID: 15292061
    25. The upregulation of Jagged2 expression on BMEC was observed upon TNF-alpha activation. Similarly,activation of endothelial cells in Tie2-tmTNF-alpha mice was characterized by increased expression of Jagged2. PMID: 18439488
    26. Results indicate JAG2 may be involved in non-syndromic cleft lip with or without cleft palate etiology in different populations. PMID: 19049519
    27. SMRT function restoration induces JAG2 down-regulation as well as multipe myeloma apoptosis. PMID: 19417136

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 6189

    OMIM: 602570

    KEGG: hsa:3714

    STRING: 9606.ENSP00000328169

    UniGene: Hs.433445



主站蜘蛛池模板: 亚洲熟妇国产熟妇肥婆| 99热精国产这里只有精品 | 男女下面进入的视频| 色综合天天综合高清网国产在线 | 吃奶摸下的激烈视频| 九色精品国产成人综合网站| 18禁黄久久久aaa片| 久久av一区二区三区| 色偷一区国产精品| 天堂在/线中文在线资源8| 亚洲人精品亚洲人成在线| 国产精品美女久久久久久久久| 久久无码国产专区精品| 香蕉人妻av久久久久天天| 国产午夜精华2020在线| 无码av专区丝袜专区| 成人精品视频99在线观看免费| 精品无码人妻一区二区三区品| 久久永久免费专区人妻精品| 自拍偷自拍亚洲精品牛影院| 国产一区二区三区久久精品| 波多野结衣久久一区二区| 丰满少妇大叫太大太粗| 亚洲蜜芽在线精品一区| 正在播放老肥熟妇露脸| 成人无遮羞视频在线观看| 一区二区在线 | 国| 真人作爱90分钟免费看视频| 无码免费无线观看在线视频| 夜夜精品无码一区二区三区| 亚洲欧洲日本综合aⅴ在线 | 无码人妻精品一区二区蜜桃百度| 四虎影视88aa久久人妻| 秋霞午夜一区二区三区黄瓜视频| 亚洲人妻av伦理| 欧美色就是色| 国产精品嫩草99av在线| 粗大的内捧猛烈进出| 国产精品久久久久影院| 国产欧美日韩视频一区二区三区 | 一本大道久久东京热无码av|