在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein fem-1 homolog A (FEM1A)

  • 中文名稱:
    人FEM1A重組蛋白
  • 貨號:
    CSB-YP871568HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人FEM1A重組蛋白
  • 貨號:
    CSB-EP871568HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人FEM1A重組蛋白
  • 貨號:
    CSB-EP871568HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人FEM1A重組蛋白
  • 貨號:
    CSB-BP871568HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人FEM1A重組蛋白
  • 貨號:
    CSB-MP871568HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    FEM1A
  • Uniprot No.:
  • 別名:
    AW611390; DKFZp762M136; EPRAP; Fem-1 homolog a (C. elegans); Fem1 homolog a; FEM1-alpha; FEM1-alpha-A; FEM1a; FEM1a-A; FEM1A_HUMAN; Fem1aa; Feminization 1 homolog a (C. elegans); Feminization 1 homolog a; MGC114562; MGC117925; Prostaglandin E receptor 4-associated protein; Protein fem-1 homolog A; Protein fem-1 homolog A-A
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-669
  • 氨基酸序列
    MDLRTAVYNA ARDGKLQLLQ KLLSGRSREE LDELTGEVAG GGTPLLIAAR YGHLDVVEYL VDRCGASVEA GGSVHFDGET IEGAPPLWAA SAAGHLDVVR SLLRRGASVN RTTRTNSTPL RAACFDGHLE VVRYLVGEHQ ADLEVANRHG HTCLMISCYK GHREIARYLL EQGAQVNRRS AKGNTALHDC AESGSLEILQ LLLGCKARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG QEQVAGGEAQ PGLPQEDPST SQGCAQPQGA PCCSSSPEEP LNGESYESCC PTSREAAVEA LELLGATYVD KKRDLLGALK HWRRAMELRH QGGEYLPKPE PPQLVLAYDY SREVNTTEEL EALITDPDEM RMQALLIRER ILGPSHPDTS YYIRYRGAVY ADSGNFERCI RLWKYALDMQ QSNLEPLSPM TASSFLSFAE LFSYVLQDRA AKGSLGTQIG FADLMGVLTK GVREVERALQ LPREPGDSAQ FTKALAIILH LLYLLEKVEC TPSQEHLKHQ TVYRLLKCAP RGKNGFTPLH MAVDKDTTNV GRYPVGRFPS LHVVKVLLDC GADPDSRDFD NNTPLHIAAQ NNCPAIMNAL IEAGAHMDAT NAFKKTAYEL LDEKLLARGT MQPFNYVTLQ CLAARALDKN KIPYKGFIPE DLEAFIELH
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling.
  • 基因功能參考文獻:
    1. FEM1 proteins are ancient regulators of Stem-Loop Binding Protein. PMID: 28118078
    2. Particular genotypes of the rs12460989 and rs8111933 loci of FEM1A gene are associated with PCOS in Chinese Han. PMID: 22678803
    3. Fem1a downregulation may be involved in, and/or a marker of, an early cell fate defect fundamental to rhabdomyosarcoma pathogenesis PMID: 16254458
    4. PGE(2)-EP4 signaling augments NF-kappaB1 p105 protein stability through EPRAP after proinflammatory stimulation, limiting macrophage activation. PMID: 18270204
    5. This study presents evidence suggesting a role for FEM1A and FEM1B in the pathogenesis of polycystic ovary syndrome. PMID: 18757445

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion. Cytoplasm.
  • 蛋白家族:
    Fem-1 family
  • 組織特異性:
    Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).
  • 數據庫鏈接:

    HGNC: 16934

    OMIM: 613538

    KEGG: hsa:55527

    STRING: 9606.ENSP00000269856

    UniGene: Hs.515082



主站蜘蛛池模板: 国产sm鞭打折磨调教视频| 亚洲午夜成人精品无码app| 国产成 人 综合 亚洲专区| 国产无套水多在线观看| 亚洲精品aa片在线观看国产| 嫖妓大龄熟妇正在播放| 国产美女久久久亚洲综合| 国产综合内射日韩久| 色婷婷av99xx| 日本亲近相奷中文字幕| 白丝乳交内射一二三区| 制服丝袜有码中文字幕在线| 亚洲国产av导航第一福利网| 亚洲成a v人片在线观看| 大肉大捧一进一出好爽视频| 装睡被陌生人摸出水好爽| 国产成人一区二区精品视频| 国产xxx视频在线观看软件| 久热在线播放中文字幕| 97人妻天天摸天天爽天天| 2018av天堂在线视频精品观看| 国产精品成人免费999| 伊人蕉影院久亚洲高清| 日本xxxx片免费观看| 搡老女人老妇女老熟妇| 国产精品久久毛片av大全日韩| 亚洲 精品 制服 校园 无码| 在线观看免费人成视频网| 亚洲精品揄拍自拍首页一 | 色欲久久久天天天综合网精品| 亚洲精品久久久久久成人| 在线不卡av片免费观看| 国模gogo无码人体啪啪| 国内精品伊人久久久久7777| 成人区精品一区二区不卡| 日日日日做夜夜夜夜做无码 | 在线人视频观看免费| 草草浮力地址线路①屁屁影院| 最近中文字幕在线中文视频| 欧美成人综合久久精品| 日韩在线 | 中文|