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  4. Recombinant Human Protein diaphanous homolog 2 (DIAPH2), partial

Recombinant Human Protein diaphanous homolog 2 (DIAPH2), partial

  • 中文名稱：
    人DIAPH2重組蛋白
  • 貨號：
    CSB-YP006891HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DIAPH2重組蛋白
  • 貨號：
    CSB-EP006891HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DIAPH2重組蛋白
  • 貨號：
    CSB-EP006891HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DIAPH2重組蛋白
  • 貨號：
    CSB-BP006891HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DIAPH2重組蛋白
  • 貨號：
    CSB-MP006891HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Dia 2; DIA; Dia drome; Dia2; Diap 2; Diap2; DIAP2_HUMAN; DIAPH 2; Diaph2; Diaphanous 2; Diaphanous homolog 2 (Drosophila); Diaphanous homolog 2; Diaphanous related formin 2; Diaphanous-related formin-2; Diaphanous2; Diaphorase 2; Diaphorase2; DRF 2; DRF2; FLJ11167; OTTHUMP00000024270; OTTHUMP00000024271; OTTHUMP00000062171; POF 2; POF; POF2; Protein diaphanous homolog 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
  • 基因功能參考文獻：
    1. Low DIA2 expression is associated with breast cancer. PMID: 29596520
    2. DIAPH2 has been associated with premature ovarian insufficiency, an aging phenotype in humans. PMID: 24037343
    3. In podocytes, INF2 appears to be an important modulator of actin-dependent behaviors that are under the control of Rho/mDia signaling. PMID: 23620398
    4. Dia2 and DIP co-tether to nascent blebs and this linkage is required for bleb formation. PMID: 23024796
    5. Long HIV filopodial formation in infected dendritic cells was dependent on the formin diaphanous 2 (Diaph2) PMID: 22685410
    6. Our results indicated that DIAPH2 may be a polygenic pleiotropy for premature ovarian failure (POF) and AMD. PMID: 21386871
    7. Dia2 plays an important role in formation of lamellipodia. PMID: 18044991

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  • 相關疾病：
    Premature ovarian failure 2A (POF2A)
  • 亞細胞定位：
    [Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.
  • 蛋白家族：
    Formin homology family, Diaphanous subfamily
  • 組織特異性：
    Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.
  • 數據庫鏈接：

    HGNC: 2877

    OMIM: 300108

    KEGG: hsa:1730

    STRING: 9606.ENSP00000321348

    UniGene: Hs.226483



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