在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein RD3 (RD3)

In Stock
  • 中文名稱:
    人RD3重組蛋白
  • 貨號:
    CSB-EP800101HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    RD3
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    30.1 kDa
  • 表達區域:
    1-195aa
  • 氨基酸序列
    MSLISWLRWNEAPSRLSTRSPAEMVLETLMMELTGQMREAERQQRERSNAVRKVCTGVDYSWLASTPRSTYDLSPIERLQLEDVCVKIHPSYCGPAILRFRQLLAEQEPEVQEVSQLFRSVLQEVLERMKQEEEAHKLTRQWSLRPRGSLATFKTRARISPFASDIRTISEDVERDTPPPLRSWSMPEFRAPKAD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina.
  • 基因功能參考文獻:
    1. Re-expressing RD3 in metastatic site-derived aggressive cells reverted their metastatic potential both in vitro and in vivo. Conversely muting RD3 in neuroblastoma cells not only heightened invasion/migration but also dictated aggressive disease with metastasis. PMID: 26375249
    2. This study reports the results of an international study aimed at delineating the clinical and molecular spectrum of RD3 mutations in retinal dystrophies. PMID: 23308101
    3. Mutations in RD3 are a very rare cause of Leber's congenital amaurosis (LCA) associated with an extremely severe form of retinal dystrophy. PMID: 22531706
    4. RD3 suppresses the basal catalytic activity of guanylyl cyclase activating proteins (GCAP) in a noncompetitive manner. PMID: 21928830
    5. Identification and sequence analysis of C1orf36. PMID: 12914764
    6. the retinopathy-associated RD3 protein is part of subnuclear protein complexes involved in diverse processes, such as transcription and splicing. PMID: 17186464

    顯示更多

    收起更多

  • 相關疾病:
    Leber congenital amaurosis 12 (LCA12)
  • 亞細胞定位:
    Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Endosome. Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
  • 組織特異性:
    Expressed in retina. Widely expressed (at protein level). In the retina the strongest immunoreactivity is detected in the inner half of the cytoplasmic portion of the photoreceptor layer, where rods and cones are found, and the external half of the outer
  • 數據庫鏈接:

    HGNC: 19689

    OMIM: 180040

    KEGG: hsa:343035

    STRING: 9606.ENSP00000355969

    UniGene: Hs.632495



主站蜘蛛池模板: 色哟哟最新在线观看入口| 国产在线拍揄自揄拍无码视频| 国产在线拍揄自揄拍无码视频| 精品无码国产一区二区三区51安| 丰满少妇弄高潮了www| 亚洲精品久久国产高清情趣图文| 国产精品国产亚洲区艳妇糸列短篇| 偷偷要色偷偷中文无码| 天天澡天天揉揉av无码| 99精品国产高清一区二区麻豆| av在线 亚洲 天堂| 欧美丰满熟妇xxxx性| 国产成人无码a区在线观看导航| 又大又粗又爽的少妇免费视频| 国产色播av在线观看| 久久无码中文字幕免费影院| 国内精品久久久久av福利秒拍 | 精品国产免费第一区二区三区| 国语自产拍在线观看对白| 大地资源中文在线观看官网第二页 | 女人爽得直叫免费视频| 婷婷五月综合激情中文字幕| 中国性欧美videofree精品| 在线亚洲97se亚洲综合在线| 青青草视频在线观看| 中文字幕无码一区二区免费| 亚洲人av在线无码影院观看| 亚洲欧美人成网站aaa| 日本动漫瀑乳h动漫啪啪免费| 国产成人女人在线观看| 色欲麻豆国产福利精品| 国产 高潮 抽搐 正在播放 | 国产性夜夜春夜夜爽免费下载| 一道本在线伊人蕉无码| 性生交大片免费看| 成人亚洲精品久久久久| 老司机免费的精品视频| 亚洲欧洲中文日韩乱码av| 色婷婷美国农夫综合激情亚洲| 性欧美牲交在线视频| 国产亚洲精品国产福利你懂的|