在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein ETHE1, mitochondrial (ETHE1)

  • 中文名稱:
    人ETHE1重組蛋白
  • 貨號:
    CSB-YP007847HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人ETHE1重組蛋白
  • 貨號:
    CSB-EP007847HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人ETHE1重組蛋白
  • 貨號:
    CSB-BP007847HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人ETHE1重組蛋白
  • 貨號:
    CSB-MP007847HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ETHE1
  • Uniprot No.:
  • 別名:
    Ethe1; ETHE1 protein; mitochondrial precursor; ETHE1_HUMAN; ethylmalonic encephalopathy 1; Ethylmalonic encephalopathy protein 1; hepatoma subtracted clone one; Hepatoma subtracted clone one protein; HSCO; mitochondrial; Protein ETHE1; Protein ETHE1 mitochondrial; YF13H12
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    8-254
  • 氨基酸序列
    VAR RQLSQRGGSG APILLRQMFE PVSCTFTYLL GDRESREAVL IDPVLETAPR DAQLIKELGL RLLYAVNTHC HADHITGSGL LRSLLPGCQS VISRLSGAQA DLHIEDGDSI RFGRFALETR ASPGHTPGCV TFVLNDHSMA FTGDALLIRG CGRTDFQQGC AKTLYHSVHE KIFTLPGDCL IYPAHDYHGF TVSTVEEERT LNPRLTLSCE EFVKIMGNLN LPKPQQIDFA VPANMRCGVQ TPTA
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus.
  • 基因功能參考文獻:
    1. observations indicate the severe impact of ETHE1 deficiency on cellular physiology and redox state PMID: 27074420
    2. ETHE1 is a major enzyme regulating endogenous glutathione persulfide /GS-(S)n-H and that its activity is controlled by polysulfidation of the Cys247 residue. PMID: 27742479
    3. ETHE1 R163W/R163Q mutations are associated with Ethylmalonic encephalopathy. PMID: 25198162
    4. Case Report: metabolic disturbances in 15-month-old male presenting with typical ethylmalonic encephalopathy associated with a homozygous ETHE1 mutation. PMID: 20978941
    5. T152I mutation of ETHE1 results in a 3-fold lower activity. PMID: 23144459
    6. role of the ETHE1 gene product in mitochondrial homeostasis and energy metabolism PMID: 14732903
    7. Mutations of ETHE1 were detected in all the typical ethylmalonic encephalopathy patients analysed, but no ETHE1 mutations were identified in patients presenting with early onset progressive encephalopathy with ethylmalonic aciduria. PMID: 16183799
    8. structural comparison of human ETHE1 and At1g53580 from Arabidopsis thaliana PMID: 16929096
    9. 14 patients with EE were investigated for mutations in the ETHE1 gene. Of the 14 patients, 5 were found to carry novel mutations. PMID: 18593870
    10. ETHE1 is a mitochondrial sulfur dioxygenase involved in catabolism of sulfide that accumulates to toxic levels in ethylmalonic encephalopathy. PMID: 19136963

    顯示更多

    收起更多

  • 相關疾病:
    Ethylmalonic encephalopathy (EE)
  • 亞細胞定位:
    Cytoplasm. Nucleus. Mitochondrion matrix.
  • 蛋白家族:
    Metallo-beta-lactamase superfamily, Glyoxalase II family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 23287

    OMIM: 602473

    KEGG: hsa:23474

    STRING: 9606.ENSP00000292147

    UniGene: Hs.7486



主站蜘蛛池模板: 亚洲成片在线观看12345| 十八禁视频在线观看免费无码无遮挡骂过| 伊人久久大香线蕉aⅴ色| 亚洲欧洲无码av一区二区三区| 午夜视频在线观看免费完整版| 性亚洲videofree高清| 夜夜高潮夜夜爽夜夜爱爱| 无码人妻一区二区三区线| 国产精品无码免费播放| 国产98在线 | 日韩| 日本日本乱码伦视频在线观看| 中文人妻熟妇乱又伦精品| 亚洲最大无码av网站观看| 五 月 丁 香 综合中文| 一道久久爱综合久久爱| 十八禁视频网站在线观看| 色妞精品av一区二区三区| 亚洲乱码日产精品bd在| 伊人久久精品无码二区麻豆| 热99re久久精品| 亚洲精品一区二区| 国产精成人品| 日日摸日日碰夜夜爽免费| 亚洲国产日韩a在线播放| 亚洲精品99久久久久中文字幕| 狂野欧美性猛xxxx乱大交| 青青久在线视观看视| 欧美乱人伦视频在线| 国产精品va无码免费| 波多野结衣av手机在线观看| 少妇高潮无套内谢| 日本少妇xxx做受| 日韩精品无码熟人妻视频| 国产精品久久久久久久久久久久午夜片 | 免费无码又爽又黄又刺激网站| 丰满人妻熟妇乱又伦精品软件 | 欧美精品18videosex性欧| 亚洲第一页综合图片自拍| 性欧美大胆免费播放| 亚洲国产综合av在线观看| 久久久久久久久久久免费精品 |