在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ETHE1 Antibody

ETHE1 Antibody

  • 中文名稱：
    ETHE1兔多克隆抗體
  • 貨號：
    CSB-PA703411
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA703411(ETHE1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA703411(ETHE1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A549 cells, human hepatocellular carcinoma tissue, mouse liver tissue, HT29 cells, Primary antibody: CSB-PA703411(ETHE1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ETHE1
  • 別名：
    Ethe1 antibody; ETHE1 protein; mitochondrial precursor antibody; ETHE1_HUMAN antibody; ethylmalonic encephalopathy 1 antibody; Ethylmalonic encephalopathy protein 1 antibody; hepatoma subtracted clone one antibody; Hepatoma subtracted clone one protein antibody; HSCO antibody; mitochondrial antibody; Protein ETHE1 antibody; Protein ETHE1 mitochondrial antibody; YF13H12 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human ETHE1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus.
  • 基因功能參考文獻(xiàn)：
    1. observations indicate the severe impact of ETHE1 deficiency on cellular physiology and redox state PMID: 27074420
    2. ETHE1 is a major enzyme regulating endogenous glutathione persulfide /GS-(S)n-H and that its activity is controlled by polysulfidation of the Cys247 residue. PMID: 27742479
    3. ETHE1 R163W/R163Q mutations are associated with Ethylmalonic encephalopathy. PMID: 25198162
    4. Case Report: metabolic disturbances in 15-month-old male presenting with typical ethylmalonic encephalopathy associated with a homozygous ETHE1 mutation. PMID: 20978941
    5. T152I mutation of ETHE1 results in a 3-fold lower activity. PMID: 23144459
    6. role of the ETHE1 gene product in mitochondrial homeostasis and energy metabolism PMID: 14732903
    7. Mutations of ETHE1 were detected in all the typical ethylmalonic encephalopathy patients analysed, but no ETHE1 mutations were identified in patients presenting with early onset progressive encephalopathy with ethylmalonic aciduria. PMID: 16183799
    8. structural comparison of human ETHE1 and At1g53580 from Arabidopsis thaliana PMID: 16929096
    9. 14 patients with EE were investigated for mutations in the ETHE1 gene. Of the 14 patients, 5 were found to carry novel mutations. PMID: 18593870
    10. ETHE1 is a mitochondrial sulfur dioxygenase involved in catabolism of sulfide that accumulates to toxic levels in ethylmalonic encephalopathy. PMID: 19136963

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Ethylmalonic encephalopathy (EE)
  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Mitochondrion matrix.
  • 蛋白家族：
    Metallo-beta-lactamase superfamily, Glyoxalase II family
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23287

    OMIM: 602473

    KEGG: hsa:23474

    STRING: 9606.ENSP00000292147

    UniGene: Hs.7486



主站蜘蛛池模板： 国产精品人妻一区夜夜爱| 久久久一本精品99久久精品88| 亚洲v天堂v手机在线| 欧美老妇交乱视频在线观看| 两个人看的www在线观看| 中国熟妇牲交视频免费| 亚洲高清无码加勒比| 日韩精品亚洲色大成网站| 国产三级在线观看播放视频| 最爽爱爱高潮免费视频| 又大又长粗又爽又黄少妇视频 | 亚洲色成人四虎在线观看| 成人网站www污污污网站| 人妻少妇精品无码专区app| 亚在线观看免费视频入口| 久久无码潮喷a片无码高潮| 精品国产av一区二区果冻传媒| 欧美熟妇性xxxx欧美熟人多毛| 亚洲日韩乱码一区二区三区四区| av无码小缝喷白浆在线观看| 小说区 综合区 首页| 成年站免费网站看v片在线| 国产乱理伦片在线观看| 少妇高潮喷水久久久影院| 漂亮人妻熟睡中被公侵犯中文版| 日韩精品一区二区av在线| 亚洲综合区图片小说区| 亚洲成a人片在线不卡一二三区| 国产有奶水哺乳期无码avav| 国产系列丝袜熟女精品网站| 韩国v欧美v亚洲v日本v| 免费大黄网站在线观| 无码国产玉足脚交极品播放| 在线天堂中文官网| 中文天堂国产最新| 中国熟妇牲交视频免费| 大又大粗又爽又黄少妇毛片免费| 中文字幕乱偷无码av先锋| 国产麻豆剧果冻传媒一区| 国产女精品视频网站免费| 亚洲男人的天堂www|