在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ETHE1 Antibody

ETHE1 Antibody

  • 中文名稱：
    ETHE1兔多克隆抗體
  • 貨號：
    CSB-PA808765
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA808765(ETHE1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A549 cells, mouse liver tissue, Primary antibody: CSB-PA808765(ETHE1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ETHE1
  • 別名：
    Ethe1 antibody; ETHE1 protein; mitochondrial precursor antibody; ETHE1_HUMAN antibody; ethylmalonic encephalopathy 1 antibody; Ethylmalonic encephalopathy protein 1 antibody; hepatoma subtracted clone one antibody; Hepatoma subtracted clone one protein antibody; HSCO antibody; mitochondrial antibody; Protein ETHE1 antibody; Protein ETHE1 mitochondrial antibody; YF13H12 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human ETHE1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus.
  • 基因功能參考文獻：
    1. observations indicate the severe impact of ETHE1 deficiency on cellular physiology and redox state PMID: 27074420
    2. ETHE1 is a major enzyme regulating endogenous glutathione persulfide /GS-(S)n-H and that its activity is controlled by polysulfidation of the Cys247 residue. PMID: 27742479
    3. ETHE1 R163W/R163Q mutations are associated with Ethylmalonic encephalopathy. PMID: 25198162
    4. Case Report: metabolic disturbances in 15-month-old male presenting with typical ethylmalonic encephalopathy associated with a homozygous ETHE1 mutation. PMID: 20978941
    5. T152I mutation of ETHE1 results in a 3-fold lower activity. PMID: 23144459
    6. role of the ETHE1 gene product in mitochondrial homeostasis and energy metabolism PMID: 14732903
    7. Mutations of ETHE1 were detected in all the typical ethylmalonic encephalopathy patients analysed, but no ETHE1 mutations were identified in patients presenting with early onset progressive encephalopathy with ethylmalonic aciduria. PMID: 16183799
    8. structural comparison of human ETHE1 and At1g53580 from Arabidopsis thaliana PMID: 16929096
    9. 14 patients with EE were investigated for mutations in the ETHE1 gene. Of the 14 patients, 5 were found to carry novel mutations. PMID: 18593870
    10. ETHE1 is a mitochondrial sulfur dioxygenase involved in catabolism of sulfide that accumulates to toxic levels in ethylmalonic encephalopathy. PMID: 19136963

    顯示更多

    收起更多

  • 相關疾病：
    Ethylmalonic encephalopathy (EE)
  • 亞細胞定位：
    Cytoplasm. Nucleus. Mitochondrion matrix.
  • 蛋白家族：
    Metallo-beta-lactamase superfamily, Glyoxalase II family
  • 組織特異性：
    Ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 23287

    OMIM: 602473

    KEGG: hsa:23474

    STRING: 9606.ENSP00000292147

    UniGene: Hs.7486



主站蜘蛛池模板： 人妻一本久道久久综合久久鬼色| 中文字幕三级人妻无码视频| 青草青草久热国产精品| 国产如狼似虎富婆找强壮黑人 | 成人免费无码不卡毛片| 国产精品一区二区av片| 国产亚洲精品第一综合麻豆 | 97狠狠狠狼鲁亚洲综合网| 欧美成人一区二区三区片免费| 亚洲精品自在在线观看| 欧美激情乱人伦| 日本久久高清一区二区三区毛片| 精品久久久久久亚洲中文字幕| 久久久国产精品人人片| 80s国产成年女人毛片| 人妻激情偷乱一区二区三区| 国产熟妇另类久久久久久| 高清无码爆乳潮喷在线观看 | 久久久精品人妻一区二区三区蜜桃 | 无码一区二区三区av免费蜜桃| 人妻无码久久一区二区三区免费| 成人无码av片在线观看| 亚洲精品一区国产| 伊人伊成久久人综合网996| 午夜伦费影视在线观看| 小说区 图片区色 综合区| 欧美性xxxx狂欢老少配| 伊人精品一本久久综合| 曰本女人牲交高潮视频| 丰满人妻精品国产99aⅴ| 久久久久人妻一区精品色欧美| 欧美又粗又大又硬又长又爽视频| 亚洲精品av网站在线观看| 欧美人与物videos另类| 国产成人精品午夜福利| 国产爆乳无码视频在线观看 | 国产精品自在拍首页视频| 欧美不卡一区二区三区| 日本孕妇潮喷高潮视频| 动漫av纯肉无码免费播放 | 曰韩少妇内射免费播放|