在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Prolyl endopeptidase (PREP)

Recombinant Human Prolyl endopeptidase (PREP)

  • 中文名稱：
    人PREP重組蛋白
  • 貨號：
    CSB-YP018664HU(A4)
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PREP重組蛋白
  • 貨號：
    CSB-EP018664HU(A4)-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PREP重組蛋白
  • 貨號：
    CSB-BP018664HU(A4)
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PREP重組蛋白
  • 貨號：
    CSB-MP018664HU(A4)
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    dJ355L5.1 (prolyl endopeptidase); HGNC:9358; MGC16060; OTTHUMP00000040498; PE; PEP; Post proline cleaving enzyme; Post-proline cleaving enzyme; PPCE_HUMAN; Prep; Prolyl endopeptidase; Prolyl oligopeptidase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-710
  • 氨基酸序列
    MLSLQYPDVY RDETAVQDYH GHKICDPYAW LEDPDSEQTK AFVEAQNKIT VPFLEQCPIR GLYKERMTEL YDYPKYSCHF KKGKRYFYFY NTGLQNQRVL YVQDSLEGEA RVFLDPNILS DDGTVALRGY AFSEDGEYFA YGLSASGSDW VTIKFMKVDG AKELPDVLER VKFSCMAWTH DGKGMFYNSY PQQDGKSDGT ETSTNLHQKL YYHVLGTDQS EDILCAEFPD EPKWMGGAEL SDDGRYVLLS IREGCDPVNR LWYCDLQQES SGIAGILKWV KLIDNFEGEY DYVTNEGTVF TFKTNRQSPN YRVINIDFRD PEESKWKVLV PEHEKDVLEW IACVRSNFLV LCYLHDVKNI LQLHDLTTGA LLKTFPLDVG SIVGYSGQKK DTEIFYQFTS FLSPGIIYHC DLTKEELEPR VFREVTVKGI DASDYQTVQI FYPSKDGTKI PMFIVHKKGI KLDGSHPAFL YGYGGFNISI TPNYSVSRLI FVRHMGGILA VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE GYTSPKRLTI NGGSNGGLLV AACANQRPDL FGCVIAQVGV MDMLKFHKYT IGHAWTTDYG CSDSKQHFEW LVKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSL KFIATLQYIV GRSRKQSNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI ARCLNVDWIP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
  • 基因功能參考文獻：
    1. These findings provide evidence for newly-discovered roles for PREP in mechanisms regulating cellular plasticity through NCAM and PSA-NCAM. PMID: 27566163
    2. Study shows that the expression of POP increases with hepatocyte steatosis suggesting an important role in hepatocytes steatosis and possibly NAFLD. PMID: 27760195
    3. It was found that human PREP behaves identically to the porcine homolog, displaying a double bell-shaped pH profile and a pH-dependent solvent kinetic isotope effect of the kcat/Km, features that set it apart from the related exopeptidase dipeptidyl peptidase IV (DPP IV). PMID: 28062644
    4. TLR4 activation releases prolyl endopeptidase containing exosomes from airway epithelial cells. PMID: 26222144
    5. This study found that circulating PREP activity was substantially reduced in all cirrhotic patients but those changes did not have evident correlation to hepatic encephalopathy. PMID: 26420028
    6. PEP was significantly and positively associated with delinquent, aggressive, externalizing and internalizing behavior subscales. PMID: 26165750
    7. PREP redox inactivation is due to oxidation of cysteine residues and consequent oligomerization through intermolecular disulfide bonds. PMID: 25236746
    8. Data indicate that SAXS analysis showed that presequence protease (hPreP) open states and substrate binding dynamics. PMID: 24931469
    9. The determination of PEP activity in the plasma may be a safe, minimally invasive and inexpensive way to define the aggressiveness of CRC in daily practice. PMID: 24465166
    10. first demonstration of colocalization of PREP and pathological proteins in the human brain, supporting the view that, at least in spatial terms, PREP could be associated with pathogenesis of neurodegenerative diseases PMID: 23562579
    11. These results indicate that POP may be a positive regulator of cell cycle progression by regulating the exit from and/or reentry into the cell cycle by KATO III cells. PMID: 24269815
    12. interaction between prolyl oligopeptidase and glyceraldehyde-3-phosphate dehydrogenase is required for cytosine arabinoside-induced glyceraldehyde-3-phosphate dehydrogenase nuclear translocation and cell death PMID: 23348613
    13. Oxidative stress and the levels of endogenous plasma prolyl oligopeptidase (PREP) inhibitor alpha-2-macroglobulin (alpha2M) decrease PREP activity in multiple sclerosis patients. PMID: 23643808
    14. PREP may be associated with secretory processes as well as in reproduction. A more abundant expression of PREP in malignant than benign tumors suggests that PREP may be associated with expansion and metastasis of tumors. PMID: 22740343
    15. analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein alpha PMID: 22750443
    16. PREP is a regulatory target and a regulatory element in cell signalling. This is the first report of a direct influence of a cell signalling molecule, retinoic acid, on PREP expression. PMID: 21487212
    17. Molecular modeling and docking based approaches were used to unravel questions like differences in ligand binding affinities in three POP species (porcine, human and A. thaliana). PMID: 22132071
    18. These results indicate that POP is a part of the machinery that controls the cell cycle. PMID: 21620802
    19. Results indicate that there is no strong and direct interaction between POP and GAP43 at physiological conditions. PMID: 20869470
    20. The constitutive expression of PREP mRNA in chronic lymphocytic leukemia was demonstrated. PMID: 20534982
    21. Cytosolic Prolyl endopeptidase activity significantly increased in clear cell renal cell carcinoma, urothelial carcinoma of the renal pelvis and head and neck squamous cell carcinoma. PMID: 20362629
    22. Plasma levels of PREP activity as well as those of their endogenous inhibitor are suggested as biomarkers of inflammation and oxidative stress in multiple sclerosis PMID: 20370893
    23. The high activity of prolyl endopeptidase in the human cortex suggests that prolyl endopeptidase could play a role in cortical functions. Activity in humans is highest in the frontal lobe and cytosolic fractions. PMID: 11792464
    24. The activities of pyroglutamyl peptidase I and prolyl endopeptidase in necrozoospermia were found to be higher in the corresponding soluble and particulate sperm fractions, respectively, with respect to those measured in normozoospermic semen PMID: 15380924
    25. primary structure, recombinant expression and homology modelling of brain prolyl oligopeptidase PMID: 15838896
    26. Mainly localized to perinuclear space and associated with microtubulin cytoskeleton in human neuroblastoma and glioma. Novel functions in axonal transport and/or protein secretion. PEP inhibitors may be useful in variety of related clinical conditions. PMID: 16092940
    27. data demonstrate for the first time prolyl endopeptidase turnover of humanin by a limited post-cysteine as well as post-proline proteolysis resulting in the inactivation of this potentially apoptosis-related factor PMID: 16700513
    28. Results describe the distribution of immunoreactive prolyl oligopeptidase in human and rat brain. PMID: 17401647
    29. The results rule out a causative role of POP in the pathogenesis of CD and strongly suggest that other peptidases are needed to eliminate gliadin-derived, immunoactive and toxic peptides larger than 33-mer, which is a POP inhibitor. PMID: 17454876
    30. Data reveal for the first time the presence of a new side opening in prolyl oligopeptidase that was not observed in any of the crystallographic structures described to date. PMID: 19782684

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase S9A family
  • 數據庫鏈接：

    HGNC: 9358

    OMIM: 600400

    KEGG: hsa:5550

    STRING: 9606.ENSP00000358106

    UniGene: Hs.436564



主站蜘蛛池模板： 成人免费毛片内射美女-百度| 日韩人妻无码免费视频一二区| 欧美成aⅴ人高清免费观看| 国产大陆亚洲精品国产| 一本一本久久aa综合精品| 欧美性开放情侣网站| 免费无码又爽又刺激成人| 欧美无人区码suv| 熟女体下毛毛黑森林| 精品久久久无码中文字幕边打电话| 欧美阿v天堂视频在99线| 亚洲精品在看在线观看| 超碰97久久国产精品牛牛| 99久久婷婷国产综合精品电影 | 一本一道波多野结衣av一区| 自拍区小说区图片区亚洲| 国产内射一区亚洲| 999久久久国产精品| 久久精品a亚洲国产v高清不卡| 久久久喷潮一区二区三区| 大伊香蕉精品一区二区| 同性男男黄g片免费网站| 人妻系列无码专区久久五月天| 亚洲国产欧美日韩精品一区二区三区| 又色又爽又黄高潮的免费视频 | 亚洲中文字幕久久无码精品| 亚洲国产成人超a在线播放| 亚洲第一福利网站在线观看| 亚洲人成电影在线观看影院| 在线亚洲高清揄拍自拍一品区| 女上男下啪啪激烈高潮无遮盖| 国产69精品久久久久人妻| 久久综合亚洲鲁鲁五月天| 日本高清在线www3344| 国产精品无码一区二区三区在| 亚洲国产精品成人天堂| 国产成+人+综合+亚洲专区| 色在线亚洲视频www| 欧美成年视频在线观看| 丁香婷婷综合久久来来去| 国产精品成人99久久久久|