在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Proline-rich protein 11 (PRR11)

  • 中文名稱:
    人PRR11重組蛋白
  • 貨號:
    CSB-YP836225HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PRR11重組蛋白
  • 貨號:
    CSB-EP836225HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PRR11重組蛋白
  • 貨號:
    CSB-BP836225HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PRR11重組蛋白
  • 貨號:
    CSB-MP836225HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    PRR11
  • Uniprot No.:
  • 別名:
    FLJ11029 ; Homo sapiens proline rich 11 ; Proline rich protein 11 ; Proline-rich protein 11; PRR 11; Prr11; PRR11_HUMAN; transcription repressor of MHCII
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達(dá)區(qū)域:
    1-360
  • 氨基酸序列
    MPKFKQRRRK LKAKAERLFK KKEASHFQSK LITPPPPPPS PERVGISSID ISQSRSWLTS SWNFNFPNIR DAIKLWTNRV WSIYSWCQNC ITQSLEVLKD TIFPSRICHR ELYSVKQQFC ILESKLCKLQ EALKTISESS SCPSCGQTCH MSGKLTNVPA CVLITPGDSK AVLPPTLPQP ASHFPPPPPP PPLPPPPPPL APVLLRKPSL AKALQAGPLK KDGPMQITVK DLLTVKLKKT QSLDEKRKLI PSPKARNPLV TVSDLQHVTL KPNSKVLSTR VTNVLITPGK SQMDLRKLLR KVDVERSPGG TPLTNKENME TGTGLTPVMT QALRRKFQLA HPRSPTPTLP LSTSSFDEQN
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays a critical role in cell cycle progression.
  • 基因功能參考文獻(xiàn):
    1. PRR11 plays an oncogenic role in hepatocellular carcinoma (HCC) progression, through activating the Wnt/beta-catenin signaling pathway, and may represent a valuable prognostic marker and therapeutic target for HCC. PMID: 30248355
    2. PRR11 positively regulated cell proliferation-related proteins, including c-myc and cyclin D1, and increased and decreased the expression of matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 and PRR11 expression was mediated by the phosphoinositide 3-kinase/AKT/beta-catenin signaling pathway. PMID: 30165366
    3. these findings further illustrate the suppressive role of miR-195 in prostate cancer (PCa), and indicate a novel role of PRR11 in PCa. Importantly, the newly identified miR-195/PRR11 axis may aid with identifying potential therapeutic targets in PCa. PMID: 29393495
    4. PRR11 regulated self-renewal and tumorigenicity of gastric cancer stem cells through MAPK signaling, and could be used as a therapeutic target for gastric cancer. PMID: 30007956
    5. these findings indicated that miR-144-3p induced cell cycle arrest and apoptosis in pancreatic cancer by targeting PRR11. PMID: 28574724
    6. p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. PMID: 28257042
    7. Microarray analysis revealed that several genes involved in cell proliferation, cell adhesion, and cell migration were altered in PRR11-knockout cells. PMID: 25971332
    8. PRR11 may be widely activated in human gastric cancer. PMID: 26252227
    9. Targeted depletion of PRR11 caused a dramatic cell cycle arrest followed by massive apoptotic cell death, and eventually resulted in a significant decrease in growth and viability in lung cancer cell lines. PMID: 25973065
    10. PRR11-SKA2 bidirectional transcription unit, which is a novel direct target of NF-Y, is essential for the accelerated proliferation and motility of lung cancer cells PMID: 26162986
    11. Overexpression of PRR11 inhibits cell proliferation and induces premature chromatin condensation. PMID: 25666944
    12. our results strongly demonstrated that this newly identified gene, PRR11, had a critical role in both cell cycle progression and tumorigenesis, and might serve as a novel potential target in the diagnosis and/or treatment of human lung cancer. PMID: 23246489
    13. the apparent occurrence of an unusual TG 3' splice site in intron 10 is discussed PMID: 17672918

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus.
  • 組織特異性:
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 25619

    OMIM: 615920

    KEGG: hsa:55771

    STRING: 9606.ENSP00000262293

    UniGene: Hs.631750



主站蜘蛛池模板: 天堂中文在线8最新版地址| 精品aⅴ一区二区三区| 国产亚洲精品福利视频| 狠狠色狠狠色综合日日五| 一本一道久久综合狠狠老| 日本又色又爽又黄的a片吻戏| 国产成人免费无庶挡视频| 日本熟妇厨房bbw| 天天躁日日躁狠狠躁av麻豆| 人人超碰人摸人爱| 中字幕视频在线永久在线| 精品国产天堂综合一区在线| 成人性生交大片免费看视频app| 久久久一本精品99久久精品66| 日韩人妻潮喷中文在线视频 | av无码免费岛国动作片不卡| 亚洲国产精品无码久久98| 亚洲午夜免费福利视频| 日韩a片无码一区二区三区电影| 人妻熟女一区二区三区app下载| 亚洲精品国产精华液| 超碰97人人做人人爱亚洲| 亚洲色中文字幕在线播放| 久久成人a毛片免费观看网站| 爆乳熟妇一区二区三区| 国产午夜福利院757视频| 大战丰满无码人妻50p| 亚洲中文字幕无码中文字在线| 成年午夜性影院免费观看| 亚洲精品第一国产综合国服瑶| 三级特黄60分钟在线播放| 亚欧洲精品在线视频免费观看| 少妇被爽到高潮在线观看| 在线播放国产精品三级| 激情综合五月| av在线亚洲欧洲日产一区二区| 久热这里只有精品12| 国产女主播喷水视频在线观看| 国产成人啪精品视频网站| 亚洲色大成网站久久久| 国产精品久久午夜夜伦鲁鲁|