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  4. Recombinant Human Probable phospholipid-transporting ATPase IB (ATP8A2), partial

Recombinant Human Probable phospholipid-transporting ATPase IB (ATP8A2), partial

  • 中文名稱：
    Recombinant Human Probable phospholipid-transporting ATPase IB(ATP8A2) ,partial
  • 貨號：
    CSB-YP865134HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Probable phospholipid-transporting ATPase IB(ATP8A2) ,partial
  • 貨號：
    CSB-EP865134HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Probable phospholipid-transporting ATPase IB(ATP8A2) ,partial
  • 貨號：
    CSB-EP865134HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Probable phospholipid-transporting ATPase IB(ATP8A2) ,partial
  • 貨號：
    CSB-BP865134HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Probable phospholipid-transporting ATPase IB(ATP8A2) ,partial
  • 貨號：
    CSB-MP865134HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ATP8A2
  • Uniprot No.：
  • 別名：
    AT8A2_HUMAN; ATP; Atp8a2; ATPase aminophospholipid transporter class I type 8A member 2; ATPase aminophospholipid transporter like class I type 8A member 2; ATPase class I type 8A member 2; ATPase phospholipid transporting 8A2; ATPIB; CAMRQ4; EC=3.6.3.1; IB; ML-1; ML1; P4 ATPase flippase complex alpha subunit ATP8A2; Probable phospholipid-transporting ATPase IB
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
  • 基因功能參考文獻：
    1. Study describes a new ATP8A2 gene mutations associated with a novel syndrome that includes encephalopathy, intellectual disability, severe hypotonia, chorea and optic atrophy. The data expand both the genetic and phenotypic spectrum associated with ATP8A2 gene mutations. PMID: 27679995
    2. ATP8A2 is involved in the development of the cerebro-cerebellar structures required for posture and gait. PMID: 22892528
    3. CDC50A is the beta-subunit of ATP8A2 and is crucial for the correct folding, stable expression, export from endoplasmic reticulum, and phosphatidylserine flippase activity of ATP8A2 PMID: 21454556
    4. P4-ATPase Atp8a2 is a phosphatidylserine flippase in photoreceptor disc membranes PMID: 19778899
  • 相關疾病：
    Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 4 (CMARQ4)
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Golgi apparatus. Endosome. Cell projection, cilium, photoreceptor outer segment. Cell membrane. Photoreceptor inner segment.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
  • 組織特異性：
    Strongly expressed in the brain, cerebellum, retina and testis.
  • 數據庫鏈接：

    HGNC: 13533

    OMIM: 605870

    KEGG: hsa:51761

    STRING: 9606.ENSP00000371070

    UniGene: Hs.444957



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