在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Potassium voltage-gated channel subfamily C member 2 (KCNC2), partial

Recombinant Human Potassium voltage-gated channel subfamily C member 2 (KCNC2), partial

  • 中文名稱：
    人KCNC2重組蛋白
  • 貨號：
    CSB-YP842738HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KCNC2重組蛋白
  • 貨號：
    CSB-EP842738HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KCNC2重組蛋白
  • 貨號：
    CSB-EP842738HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KCNC2重組蛋白
  • 貨號：
    CSB-BP842738HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KCNC2重組蛋白
  • 貨號：
    CSB-MP842738HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KCNC2
  • Uniprot No.：
  • 別名：
    KCNC2; Potassium voltage-gated channel subfamily C member 2; Shaw-like potassium channel; Voltage-gated potassium channel Kv3.2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels. Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons. Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner.
  • 基因功能參考文獻：
    1. these data suggest that reduction of KCNC2 is associated with modified hepatic gluconeogenesis and increased ER stress on obesity-mediated diabetic risk. PMID: 27623749
    2. Kv3.2 is not different in distribution or in level between normal and schizophrenia cases, nor influenced by antipsychotic drugs, in any brain region tested PMID: 23628987
    3. This family's complex phenotype is associated with a new chromosomal deletion, which suggests potential roles for the two genes, KCNC2 and ATXN7L3B, in human neurological disease. PMID: 23475819
    4. Although all KV3 subunit transcripts are significantly expressed at embryonic age in whole brain extracts, only KV3.1, KV3.2 and KV3.4 subunit transgenic proteins are present. PMID: 21912965
  • 相關疾病：
    A chromosomal aberration involving KCNC2 has been found in a mother and her two children with varying degrees of neurodevelopmental delay and cerebellar ataxia. One child also exhibits episodes of unresponsiveness suggestive of absence seizures and facial dysmorphism. Deletion at 12q21.1 deletes exons 3-5 of KCNC2.
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Perikaryon. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome. Cell junction, synapse. Apical cell membrane. Basolateral cell membrane.
  • 蛋白家族：
    Potassium channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.2/KCNC2 sub-subfamily
  • 數據庫鏈接：

    HGNC: 6234

    OMIM: 176256

    KEGG: hsa:3747

    STRING: 9606.ENSP00000449253

    UniGene: Hs.27214



主站蜘蛛池模板： 国产亚洲精品久久综合阿香| 日韩国产成人精品视频| 久久96国产精品久久久| 久久天堂av综合合色蜜桃网 | 欧洲一卡2卡3卡4卡乱码视频| 久久99热狠狠色精品一区| 久久精品a亚洲国产v高清不卡| 午夜伦yy44880影院| 亚洲爆乳成av人在线视水卜| 久久久久久久久毛片精品| 午夜成人亚洲理伦片在线观看 | 欧美品无码一区二区三区在线蜜桃| 亚洲精品久久国产精品| 无码少妇一区二区性色av| 美女张开腿让男人桶爽| 又粗又紧又湿又爽的视频| 衣服被扒开强摸双乳18禁网站| 久久人人爽人人爽人人片av不 | 日本无遮挡吸乳呻吟视频| 嫩草av久久伊人妇女超级a| 色欲久久久天天天综合网精品| 久久久久青草线蕉亚洲麻豆| 无码大潮喷水在线观看| 欧美又大又色又爽aaaa片| 水蜜桃av无码一区二区| 欧美性生交xxxxx无码久久久 | 国产视频一区二区| 女人爽到高潮免费视频大全| 亚洲精品综合一区二区三区在线| 亚洲欧美午夜理论电影在线观看| 人妻熟女一区| 97在线精品视频免费| 色综合天天综合欧美综合| 国产精品一区二区av在线观看 | 美女黄网站18禁免费看| 人人超人人超碰超国产97超碰 | 色琪琪丁香婷婷综合久久| 欧美亚洲综合在线一区| 国产国语毛片在线看国产| 国产黑色丝袜视频在线观看网红| 国精产品一区一区三区mba下载|