在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KCNC2 Antibody

  • 中文名稱:
    KCNC2兔多克隆抗體
  • 貨號:
    CSB-PA616429
  • 規格:
    ¥2024
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded human brain tissue using Potassium Channel Kv3.2b antibody.
    • Western blot analysis of extracts from HepG2 cells, using Potassium Channel Kv3.2b antibody.
    • Western blot analysis of extracts from 293 cells (Lane 2), using Potassium Channel Kv3.2b antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KCNC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KCNC2
  • 別名:
    KCNC2; Potassium voltage-gated channel subfamily C member 2; Shaw-like potassium channel; Voltage-gated potassium channel Kv3.2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human Potassium Channel Kv3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels. Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons. Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner.
  • 基因功能參考文獻:
    1. these data suggest that reduction of KCNC2 is associated with modified hepatic gluconeogenesis and increased ER stress on obesity-mediated diabetic risk. PMID: 27623749
    2. Kv3.2 is not different in distribution or in level between normal and schizophrenia cases, nor influenced by antipsychotic drugs, in any brain region tested PMID: 23628987
    3. This family's complex phenotype is associated with a new chromosomal deletion, which suggests potential roles for the two genes, KCNC2 and ATXN7L3B, in human neurological disease. PMID: 23475819
    4. Although all KV3 subunit transcripts are significantly expressed at embryonic age in whole brain extracts, only KV3.1, KV3.2 and KV3.4 subunit transgenic proteins are present. PMID: 21912965
  • 相關疾病:
    A chromosomal aberration involving KCNC2 has been found in a mother and her two children with varying degrees of neurodevelopmental delay and cerebellar ataxia. One child also exhibits episodes of unresponsiveness suggestive of absence seizures and facial dysmorphism. Deletion at 12q21.1 deletes exons 3-5 of KCNC2.
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Perikaryon. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome. Cell junction, synapse. Apical cell membrane. Basolateral cell membrane.
  • 蛋白家族:
    Potassium channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.2/KCNC2 sub-subfamily
  • 數據庫鏈接:

    HGNC: 6234

    OMIM: 176256

    KEGG: hsa:3747

    STRING: 9606.ENSP00000449253

    UniGene: Hs.27214



主站蜘蛛池模板: 柠檬福利精品视频导航| ā片在线观看免费观看| 国产成人无码免费看片软件| 亚洲国产制服丝袜无码av| 春药高潮抽搐流白浆在线观看| 久久久久国产精品人妻aⅴ果冻| 亚洲国产欧洲综合997久久| 熟妇人妻午夜寂寞影院| 四库影院永久国产精品地址| 久久亚洲国产精品五月天婷| 久久精品99国产国产精| 99视频精品国产免费观看| 久九九精品免费视频| 一本色综合亚洲精品蜜桃冫| 极品少妇被后入内射视| 亚洲综合无码中文字幕第2页 | 亚洲精品精华液一区二区| 国产精品自在拍在线拍| 波多野结衣一区二区三区高清| 亚洲 综合 欧美 动漫 丝袜| 无遮18禁在线永久免费观看挡| 人妻无码一区二区三区四区| 天天操夜夜操| 国产 日韩 欧美 视频 制服| 国产精品美女久久久久av爽李琼 | 国产精品乱码一区二区三| 亚洲日韩欧美国产另类综合| 欧美精品一国产成人综合久久| 国产亚洲精品一区二区三区| 日本丰满熟妇videossex| 久久超碰极品视觉盛宴| 精品国产三级a∨在线| 日本无翼乌邪恶大全彩h| 又大又粗又爽免费视频a片| 国产成人无码一区二区在线播放| 亚洲精品一品区二品区三品区| 夫前人妻被灌醉侵犯在线| 久久久久久久综合日本| 女人大荫蒂毛茸茸视频| 欧美韩中文精品有码视频在线| 国产精品va在线播放|