在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Polymerase delta-interacting protein 2 (POLDIP2)

  • 中文名稱:
    人POLDIP2重組蛋白
  • 貨號:
    CSB-YP896496HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人POLDIP2重組蛋白
  • 貨號:
    CSB-EP896496HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人POLDIP2重組蛋白
  • 貨號:
    CSB-BP896496HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人POLDIP2重組蛋白
  • 貨號:
    CSB-MP896496HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    POLDIP2
  • Uniprot No.:
  • 別名:
    38 kDa DNA polymerase delta interaction protein; delta interacting protein 2; DNA polymerase delta interaction protein p38; p38; PDIP 2; PDIP 38; PDIP2; PDIP2_HUMAN; PDIP38; POLD 4; POLD4; Poldip2; Polymerase (DNA directed) delta interacting protein 2; Polymerase delta interacting protein 38; Polymerase delta-interacting protein 2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length of mature protein
  • 表達區域:
    52-368
  • 氨基酸序列
    SSRNRPEGKVLETVGVFEVPKQNGKYETGQLFLHSIFGYRGVVLFPWQARLYDRDVASAAPEKAENPAGHGSKEVKGKTHTYYQVLIDARDCPHISQRSQTEAVTFLANHDDSRALYAIPGLDYVSHEDILPYTSTDQVPIQHELFERFLLYDQTKAPPFVARETLRAWQEKNHPWLELSDVHRETTENIRVTVIPFYMGMREAQNSHVYWWRYCIRLENLDSDVVQLRERHWRIFSLSGTLETVRGRGVVGREPVLSKEQPAFQYSSHVSLQASSGHMWGTFRFERPDGSHFDVRIPPFSLESNKDEKTPPSGLHW
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites. May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1).
  • 基因功能參考文獻:
    1. Increasing mitochondrial lipoylation by forced expression of Poldip2 increases respiration and reduces the growth rate of cancer cells. Study unveils a regulatory mechanism of catabolic enzymes required for metabolic plasticity and highlights the role of Poldip2 as key during hypoxia and cancer cell metabolic adaptation. PMID: 29434038
    2. findings establish that PolDIP2 can regulate the translesion synthesis polymerase and primer extension activities of PrimPol PMID: 26984527
    3. POLDIP2 plays a crucial role in Tau aggregation via the impairment of autophagy activity, providing insight into Tau aggregation in Tau pathology. PMID: 25930997
    4. PDIP38 can respond to genotoxic or transcriptional stresses by undergoing translocation to the spliceosomes, where it is a required participant in the regulation of MDM2 alternative splicing. PMID: 23989611
    5. DNA polymerase delta-interacting protein 2 is a processivity factor for DNA polymerase lambda during 8-oxo-7,8-dihydroguanine bypass. PMID: 24191025
    6. We demonstrate that PDIP38 (Poldelta interacting protein of 38kDa) directly interacts with the TLS polymerase Poleta. PDIP38 is able to interact directly not only with Poleta but also with the specialized polymerases Rev1 and Polzeta (via Rev7). PMID: 20554254
    7. suggest that the TNFAIP1/POLDIP2 complex sense-antisense architecture represents a clinically significant transcriptional structural-functional gene module associated with amplification of the genomic region on 17q11.2 in breast cancer. PMID: 20158880
    8. PDIP38 might play a role in the pol delta-mediated viral DNA replication PMID: 15811854
    9. PDIP38 is located in the mitochondrial matrix. TFAM and mitochondrial single-stranded DNA binding protein (mtSSB) are co-immunoprecipitated with PDIP38 PMID: 16428295
    10. PDIP38 can shuttle between the cytoplasmic and the nuclear compartments and that its subcellular localization is regulated by CEACAM1 PMID: 17623671
    11. Poldip2 associates with p22phox to activate Nox4, leading to regulation of focal adhesion turnover and vascular smooth muscle cell migration, thus linking reactive oxygen species production and cytoskeletal remodeling. PMID: 19574552

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion matrix. Nucleus.
  • 數據庫鏈接:

    HGNC: 23781

    OMIM: 611519

    KEGG: hsa:26073

    UniGene: Hs.241543



主站蜘蛛池模板: 粗大的内捧猛烈进出看视频| 人与禽交av在线播放| 又黄又爽又猛的视频免费| 伊人狠狠色丁香婷婷综合| 奇米四色7777中文字幕| 免费无码av片在线观看网址| 337p日本欧洲亚洲大胆69影院| 国产免费艾彩sm调教视频| 国产成人综合欧美精品久久| 久久青青草原国产精品最新片| 日韩高清在线观看永久| 天天干天天日夜夜操| 久久99亚洲精品久久99果| 精品国产黑色丝袜高跟鞋| 国产精品白丝久久av网站| 51福利国产在线观看午夜天堂 | 最新国产久免费视频在线观看| 亚洲欧美另类精品二区| 亚洲a∨无码男人的天堂| 国产午夜福利精品一区二区三区| 成 人 亚洲 综合天堂| 韩国和日本免费不卡在线v| 在线观看肉片av网站免费| 宅宅少妇无码| yyyy11111少妇无码影院| 国产ktv交换配乱婬视频| 亚洲一区二区av在线观看| 成人无码av片在线观看| 国内精品久久久人妻中文字幕| 精品亚洲成a人在线观看青青| 亚洲综合另类小说专区| 伊伊综合在线视频无码| 色偷偷av男人的天堂| 天天做av天天爱天天爽| 正在播放国产真实露脸高清| 人人妻人人澡人人爽久久av| 少妇精品无码一区二区三区 | 三个男人躁我一个爽视频免费| 欧美黑人xxxx高潮猛交| 成人午夜又粗又硬又长| 国产成人精品一区二区三区免费看|