在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POLDIP2 Antibody, FITC conjugated

  • 中文名稱:
    POLDIP2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA896496LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) POLDIP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    POLDIP2
  • 別名:
    38 kDa DNA polymerase delta interaction protein antibody; delta interacting protein 2 antibody; DNA polymerase delta interaction protein p38 antibody; p38 antibody; PDIP 2 antibody; PDIP 38 antibody; PDIP2 antibody; PDIP2_HUMAN antibody; PDIP38 antibody; POLD 4 antibody; POLD4 antibody; Poldip2 antibody; Polymerase (DNA directed) delta interacting protein 2 antibody; Polymerase delta interacting protein 38 antibody; Polymerase delta-interacting protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Polymerase delta-interacting protein 2 protein (1-200AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites. May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1).
  • 基因功能參考文獻:
    1. Increasing mitochondrial lipoylation by forced expression of Poldip2 increases respiration and reduces the growth rate of cancer cells. Study unveils a regulatory mechanism of catabolic enzymes required for metabolic plasticity and highlights the role of Poldip2 as key during hypoxia and cancer cell metabolic adaptation. PMID: 29434038
    2. findings establish that PolDIP2 can regulate the translesion synthesis polymerase and primer extension activities of PrimPol PMID: 26984527
    3. POLDIP2 plays a crucial role in Tau aggregation via the impairment of autophagy activity, providing insight into Tau aggregation in Tau pathology. PMID: 25930997
    4. PDIP38 can respond to genotoxic or transcriptional stresses by undergoing translocation to the spliceosomes, where it is a required participant in the regulation of MDM2 alternative splicing. PMID: 23989611
    5. DNA polymerase delta-interacting protein 2 is a processivity factor for DNA polymerase lambda during 8-oxo-7,8-dihydroguanine bypass. PMID: 24191025
    6. We demonstrate that PDIP38 (Poldelta interacting protein of 38kDa) directly interacts with the TLS polymerase Poleta. PDIP38 is able to interact directly not only with Poleta but also with the specialized polymerases Rev1 and Polzeta (via Rev7). PMID: 20554254
    7. suggest that the TNFAIP1/POLDIP2 complex sense-antisense architecture represents a clinically significant transcriptional structural-functional gene module associated with amplification of the genomic region on 17q11.2 in breast cancer. PMID: 20158880
    8. PDIP38 might play a role in the pol delta-mediated viral DNA replication PMID: 15811854
    9. PDIP38 is located in the mitochondrial matrix. TFAM and mitochondrial single-stranded DNA binding protein (mtSSB) are co-immunoprecipitated with PDIP38 PMID: 16428295
    10. PDIP38 can shuttle between the cytoplasmic and the nuclear compartments and that its subcellular localization is regulated by CEACAM1 PMID: 17623671
    11. Poldip2 associates with p22phox to activate Nox4, leading to regulation of focal adhesion turnover and vascular smooth muscle cell migration, thus linking reactive oxygen species production and cytoskeletal remodeling. PMID: 19574552

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion matrix. Nucleus.
  • 數據庫鏈接:

    HGNC: 23781

    OMIM: 611519

    KEGG: hsa:26073

    UniGene: Hs.241543



主站蜘蛛池模板: 98久久人妻少妇激情啪啪| 国产精品理论片| 国产精品无码免费专区午夜| 亚洲欧洲日韩国内高清| 五月综合缴情婷婷六月| 欧美人与动牲交免费观看| 国产精品特级毛片一区二区三区| 色一情一乱一伦一区二区三区| 人与禽性视频77777| 亚洲综合无码无在线观看| 奇米影视7777狠狠狠狠影视| 人妻少妇精品久久久久久| 精品久久久久国产免费| 亚洲性无码av在线| 2021国产精品午夜久久| 国产无遮挡裸体免费视频在线观看 | 2019最新中文字幕在线观看| 无码粉嫩虎白一线天在线观看| 国产精品刮毛| 亚洲国产精品成人精品无码区蜜臀| 亚洲国产日韩制服在线观看 | 无码不卡av东京热毛片| 国内裸体无遮挡免费视频| 无码被窝影院午夜看片爽爽jk | 欧美日韩国产精品自在自线| 无遮挡午夜男女xx00动态| 亚洲色无码中文字幕手机在线| 成年男女免费视频网站| 曰韩少妇内射免费播放| 亚洲欧美成人片在线观看| 少妇精品视频无码专区| 精品深夜av无码一区二区老年| 亚洲欧美一区二区三区在线| 18禁无遮挡羞羞污污污污免费| 国产吃奶在线观看| 国语自产少妇精品视频| 国精品午夜福利视频不卡| 色哟哟免费视频播放网站| 国产成人无码一区二区三区| 国产舌乚八伦偷品w中| 麻豆果冻精东九一传媒mv|