在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4), partial

  • 中文名稱:
    人PIK3R4重組蛋白
  • 貨號:
    CSB-YP858716HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PIK3R4重組蛋白
  • 貨號:
    CSB-EP858716HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人PIK3R4重組蛋白
  • 貨號:
    CSB-EP858716HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PIK3R4重組蛋白
  • 貨號:
    CSB-BP858716HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PIK3R4重組蛋白
  • 貨號:
    CSB-MP858716HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    MGC102700; P150; Phosphatidylinositol 3 kinase associated p150; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 4; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 4 p150; Phosphoinositide 3 kinase adaptor protein; Phosphoinositide 3 kinase regulatory subunit 4; Phosphoinositide 3 kinase regulatory subunit 4 p150; Phosphoinositide 3 kinase regulatory subunit polypeptide 4; Phosphoinositide 3 kinase regulatory subunit polypeptide 4 p150; Phosphoinositide 3-kinase adaptor protein; Phosphoinositide 3-kinase regulatory subunit 4; PI3 kinase p150 subunit; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; PI3R4_HUMAN; PIK3R 4; PIK3R4; VPS 15; VPS15
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2.
  • 基因功能參考文獻:
    1. A missense mutation in PIK3R4 (phosphoinositide 3-kinase regulatory subunit 4, named VPS15) in a family with a ciliopathy phenotype is identified. Besides being required for trafficking and autophagy, we show that VPS15 regulates primary cilium length in human fibroblasts. PMID: 27882921
    2. Both Danon Disease and glycogen storage disease type II show accumulation and altered localization of VPS15 in autophagy-incompetent fibers. However, TFEB displays a different pattern between these two lysosomal storage diseases PMID: 28102838
    3. High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia. PMID: 25840748
    4. A specific sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates both receptor degradation and cytokinesis, whereas ATG14L, a PI3K-III subunit involved in autophagy, is not required. PMID: 20643123
    5. hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells PMID: 18957027

    顯示更多

    收起更多

  • 亞細胞定位:
    Late endosome. Cytoplasmic vesicle, autophagosome. Membrane; Lipid-anchor.
  • 蛋白家族:
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 8982

    OMIM: 602610

    KEGG: hsa:30849

    STRING: 9606.ENSP00000349205

    UniGene: Hs.149032



主站蜘蛛池模板: 成人艳情一二三区| 无码av喷白浆在线播放| 亚洲成av人片天堂网| 成人做爰69片免费看网站| 国产精品香港三级国产av| av毛片无码中文字幕不卡| 肉体裸交137日本大胆摄影| 粗大的内捧猛烈进出在线视频| 一本色道久久88综合日韩精品| 国产手机在线亚洲精品观看| 久久国产超碰女女av| 亚洲乱码一区二区三区在线观看| 可以看三级的网站| 久久无码潮喷a片无码高潮| 免费无码成人av片在线在线播放 | 亚洲h在线播放在线观看h| 蕾丝av无码专区在线观看| 18禁真人抽搐一进一出免费| 国产乱码一区二区三区| 国产精品无码一区二区在线| 国产av大陆精品一区二区三区| 2020精品国产自在现线官网| 亚洲精品国产suv一区| 色综合久久久久无码专区| 欧洲精品一卡2卡三卡4卡影视| 亚洲成av人片在线播放无码| 久久精品国产精品亚洲| 大香线蕉伊人精品超碰| 国产精品区一区二区三在线播放| 日日噜噜噜噜夜夜爽亚洲精品| 全部孕妇毛片| 精品国内自产拍在线观看| 国产麻豆剧果冻传媒白晶晶| 欧美 国产 综合 欧美 视频| 18禁真人抽搐一进一出在线| 久久97超碰色中文字幕蜜芽| 波多野结衣在线观看一码| 午夜福利麻豆国产精品| 国产色情又大又粗又黄的电影| 少妇太爽了在线观看| 少妇的丰满3中文字幕|