在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Peptide-N (4)- (N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1)

Recombinant Human Peptide-N (4)- (N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1)

  • 中文名稱：
    人NGLY1重組蛋白
  • 貨號：
    CSB-YP853434HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NGLY1重組蛋白
  • 貨號：
    CSB-EP853434HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NGLY1重組蛋白
  • 貨號：
    CSB-EP853434HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NGLY1重組蛋白
  • 貨號：
    CSB-BP853434HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NGLY1重組蛋白
  • 貨號：
    CSB-MP853434HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    NGLY1; PNG1; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; PNGase; hPNGase; EC 3.5.1.52; N-glycanase 1; Peptide:N-glycanase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    2-654
  • 氨基酸序列
    AAAALGSSS GSASPAVAEL CQNTPETFLE ASKLLLTYAD NILRNPNDEK YRSIRIGNTA FSTRLLPVRG AVECLFEMGF EEGETHLIFP KKASVEQLQK IRDLIAIERS SRLDGSNKSH KVKSSQQPAA STQLPTTPSS NPSGLNQHTR NRQGQSSDPP SASTVAADSA ILEVLQSNIQ HVLVYENPAL QEKALACIPV QELKRKSQEK LSRARKLDKG INISDEDFLL LELLHWFKEE FFHWVNNVLC SKCGGQTRSR DRSLLPSDDE LKWGAKEVED HYCDACQFSN RFPRYNNPEK LLETRCGRCG EWANCFTLCC RAVGFEARYV WDYTDHVWTE VYSPSQQRWL HCDACEDVCD KPLLYEIGWG KKLSYVIAFS KDEVVDVTWR YSCKHEEVIA RRTKVKEALL RDTINGLNKQ RQLFLSENRR KELLQRIIVE LVEFISPKTP KPGELGGRIS GSVAWRVARG EMGLQRKETL FIPCENEKIS KQLHLCYNIV KDRYVRVSNN NQTISGWENG VWKMESIFRK VETDWHMVYL ARKEGSSFAY ISWKFECGSV GLKVDSISIR TSSQTFQTGT VEWKLRSDTA QVELTGDNSL HSYADFSGAT EVILEAELSR GDGDVAWQHT QLFRQSLNDH EENCLEIIIK FSDL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.
  • 基因功能參考文獻：
    1. Across these distinct evolutionary models of cytosolic NGLY1 deficiency, a consistent disruption of mitochondrial physiology was present involving modestly reduced mitochondrial content with more pronounced impairment of mitochondrial membrane potential, increased mitochondrial matrix oxidant burden, and reduced cellular respiratory capacity. PMID: 28750948
    2. Our prospective phenotyping expands the clinical spectrum of NGLY1-CDDG, offers prognostic information, and provides baseline data for evaluating therapeutic interventions PMID: 27388694
    3. The patients with NGLY1 deficiency show developmental delay, seizures, peripheral neuropathy, abnormal liver function and alacrima. PMID: 25900930
    4. This review summarizes the research history of cytoplasmic PNGase. PMID: 25398991
    5. NGLY1 mutation causes neuromotor impairment, intellectual disability, and neuropathy PMID: 25220016
    6. Data indicate that N-glycanase 1 (NGLY1) deficiency is a novel autosomal recessive disorder of the endoplasmic reticulum-associated degradation pathway associated with neurological dysfunction, abnormal tear production, and liver disease. PMID: 24651605
    7. PNGase-PUB serves not only as p97-binding module but also as a possible activator of HR23 in endoplasmic reticulum-associated degradation mechanisms. PMID: 22575648
    8. As the generation of the bulk of fOS is unaffected by co-down regulation of Ngly1p and Engase1p, alternative quantitatively important mechanisms must underlie the liberation of these fOS from either LLO or glycoproteins during protein N-glycosylation. PMID: 20668520
    9. the PUB domain functions as a p97 binding module in human peptide N-glycanase PMID: 16807242
    10. generation of an HLA-A*0201-associated epitope from tyrosinase with deamidation of Asn to Asp is dependent on glycosylation in the endoplasmic reticulum (ER), and subsequent deglycosylation by peptide-N-glycanase in the cytosol PMID: 17015730
    11. Describes the function of Yeast PNG1 and identifies similar proteins in mouse, human, D. melanogaster, C. elegans, and S. pombe. PMID: 10831608

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Congenital disorder of deglycosylation (CDDG)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Transglutaminase-like superfamily, PNGase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17646

    OMIM: 610661

    KEGG: hsa:55768

    STRING: 9606.ENSP00000280700

    UniGene: Hs.368960



主站蜘蛛池模板： 国产亚洲精品国产福利你懂的| 无码人妻精品一二三区免费| 天天狠天天透天天伊人| 亚洲欧美另类久久久精品| 国产精品成人国产乱| 熟女人妻av粗壮巨龙| 狠狠色噜噜狠狠狠狠米奇777| 国产av无码精品色午夜| av无码av天天av天天爽| 激情内射人妻1区2区3区| 特黄做受又硬又粗又大视频小说| 成+人+网+站+免费观看| 男女啪啪网站大全免费| 久久精品国产丝袜人妻| 国产肉体xxxx裸体137大胆| 女学生14毛片视频片二毛| 久久精品国产亚洲αv忘忧草| а√在线中文网新版地址在线| 亚洲成在人线视av| 色屁屁www影院免费观看入口| 好了av在线第四综合网站| 亚洲日本va中文字幕人妖| 天天av天天翘天天综合网色鬼| 日产中文字幕在线观看| 亚洲人成无码www久久久| 亚洲精品无码成人aaa片| 国产精品久久久久久熟妇吹潮软件| 亚洲精品99久久久久中文字幕| 超清中文乱码字幕在线观看| 18禁勿入网站入口永久| 精品国产av一区二区果冻传媒| 成人伊人青草久久综合网 | 亚洲最大av资源站无码av网址| 久久无码人妻精品一区二区三区| 亚洲人成网站在线播放2019| 亚洲欧洲自拍拍偷精品网| 亲近乱子伦免费视频| 美女视频黄a视频全免费| 纯肉无遮挡无码日本动漫| 美女又大又黄www免费网站| 久久不见久久见免费视频7 |