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NGLY1

Peptide-Nis a protein in humans that is encoded by NGLY1 gene. Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

NGLY1 Proteins

NGLY1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

NGLY1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

NGLY1 Proteins for Rattus norvegicus (Rat)

NGLY1 Proteins for Gallus gallus (Chicken)

NGLY1 Proteins for Homo sapiens (Human)

NGLY1 Proteins for Mus musculus (Mouse)



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