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  4. Recombinant Human Partitioning defective 3 homolog B (PARD3B), partial

Recombinant Human Partitioning defective 3 homolog B (PARD3B), partial

  • 中文名稱：
    人PARD3B重組蛋白
  • 貨號：
    CSB-YP855070HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PARD3B重組蛋白
  • 貨號：
    CSB-EP855070HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PARD3B重組蛋白
  • 貨號：
    CSB-EP855070HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PARD3B重組蛋白
  • 貨號：
    CSB-BP855070HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PARD3B重組蛋白
  • 貨號：
    CSB-MP855070HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PARD3B
  • Uniprot No.：
  • 別名：
    ALS2CR19; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 19; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein; Par 3 partitioning defective 3 homolog B; PAR3-beta; PAR3-L protein; PAR3B; PAR3beta; PAR3L; PAR3L_HUMAN; PAR3LC; Pard3b; Partitioning defective 3 beta; Partitioning defective 3 homolog B; Partitioning defective 3-like protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
  • 基因功能參考文獻：
    1. artitioning defective 3-like protein may serve as a promising prognostic marker and a potential therapeutic target for colorectal cancer treatment. Further study is necessary to understand the regulatory mechanism of partitioning defective 3-like protein in colorectal cancer and the feasibility of its application in clinic. PMID: 28443499
    2. Par3L interacts with Lkb1 and regulates the activity of AMPK signaling cascade. PMID: 27908725
    3. The association of single-nucleotide polymorphisms of PARD3B with slower progression of HIV infection to AIDS is reported. PMID: 21502085
    4. PAR3beta, expressed intrinsically or extrinsically, localizes to the tight junctions, indicating that the localization does not require the ternary complex formation. PMID: 12459187
    5. binding of 14-3-3 to Par3beta is dependent on phosphorylation PMID: 15721295

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  • 亞細胞定位：
    Endomembrane system. Cell junction. Cell junction, tight junction. Note=Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions.
  • 蛋白家族：
    PAR3 family
  • 組織特異性：
    Highly expressed in kidney, lung and skeletal muscle. Expressed at intermediate levels in brain, heart, placenta, liver and pancreas. Isoform 1 is predominant, while isoform 2 and isoform 3 are expressed at lower levels.
  • 數據庫鏈接：

    HGNC: 14446

    KEGG: hsa:117583

    UniGene: Hs.657382



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