在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human PDZ and LIM domain protein 2 (PDLIM2)

Recombinant Human PDZ and LIM domain protein 2 (PDLIM2)

  • 中文名稱：
    人PDLIM2重組蛋白
  • 貨號：
    CSB-YP856962HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PDLIM2重組蛋白
  • 貨號：
    CSB-EP856962HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PDLIM2重組蛋白
  • 貨號：
    CSB-EP856962HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PDLIM2重組蛋白
  • 貨號：
    CSB-BP856962HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PDLIM2重組蛋白
  • 貨號：
    CSB-MP856962HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PDLIM2
  • Uniprot No.：
  • 別名：
    FLJ34715; MYSTIQUE; OTTHUMP00000162522; OTTHUMP00000205197; OTTHUMP00000205198; OTTHUMP00000205199; OTTHUMP00000205200; OTTHUMP00000205202; OTTHUMP00000205203; PDLI2_HUMAN; Pdlim2; PDZ and LIM domain 2 (mystique); PDZ and LIM domain protein 2; PDZ-LIM protein mystique; SLIM ; Stat-interacting LIM protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-352
  • 氨基酸序列
    MALTVDVAGP APWGFRITGG RDFHTPIMVT KVAERGKAKD ADLRPGDIIV AINGESAEGM LHAEAQSKIR QSPSPLRLQL DRSQATSPGQ TNGDSSLEVL ATRFQGSVRT YTESQSSLRS SYSSPTSLSP RAGSPFSPPP SSSSLTGEAA ISRSFQSLAC SPGLPAADRL SYSGRPGSRQ AGLGRAGDSA VLVLPPSPGP RSSRPSMDSE GGSLLLDEDS EVFKMLQENR EGRAAPRQSS SFRLLQEALE AEERGGTPAF LPSSLSPQSS LPASRALATP PKLHTCEKCS TSIANQAVRI QEGRYRHPGC YTCADCGLNL KMRGHFWVGD ELYCEKHARQ RYSAPATLSS RA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
  • 基因功能參考文獻：
    1. The results showed that (i) the use of SPR chip led to comparable data compared to on-column streptavidin beads, (ii) gravity flow and microflow in wash and elution steps provided better results than centrifugation, and (iii) type and concentration of detergent did not significantly affect the interactome data of cancer-associated PDLIM2. PMID: 30194080
    2. We conclude that inactivation of PDLIM2 is a recurrent finding in cHL and ALCL, promotes activation of inflammatory signaling pathways and thereby contributes to their pathogenesis PMID: 27538486
    3. Data show that shRNA mediated knockdown of PDZ and LIM domain protein 2 (PDLIM2) in both primary meningioma and schwannoma leads to significant reductions in cellular proliferation. PMID: 28126595
    4. PDLIM2 is epigenetically repressed in ovarian cancer development and inhibition of PDLIM2 promoted ovarian cancer growth both in vivo and in vitro via NOS2-derived nitric oxide signaling, leading to recruitment of M2 type macrophages. PMID: 26593252
    5. The suppression of PDLIM2 expression significantly reduced cell proliferation, cell growth and neoplasm invasiveness in prostate cancer cells. PMID: 26499308
    6. epigenetic repression of PDLIM2 can be reversed by 5-aza-2-deoxycytidine and vitamin D to suppress KSHV-associated cancer cell growth PMID: 25681443
    7. PDLIM2 expression is essential for feedback regulation of the beta1-integrin-RhoA signalling axis and integration of cellular microenvironment signals with gene expression to control the polarity of breast epithelial acini structures. PMID: 24863845
    8. PDLIM2 integrates cytoskeleton signaling with gene expression in epithelial differentiation by controlling the stability of key transcription factors and COP9 signalosome activity. PMID: 24196835
    9. PDLIM2 was a direct target gene of 1,25(OH)2D3 PMID: 23584482
    10. Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases. PMID: 21814175
    11. PDLIM2 binds to Tax directly, which was mediated by a putative alpa-helix motif of PDLIM2 at amino acids 236-254. PMID: 20838382
    12. PDLIM2, an essential terminator of NF-kappaB activation, is repressed in both estrogen receptor-positive and estrogen receptor-negative breast cancer cells, suggesting one important mechanism for the constitutive activation of NF-kappaB. PMID: 20185823
    13. Data show that the PDLIM2 repression was independent of the viral regulatory protein Tax because neither short-term induction nor long-term stable expression of Tax could downregulate PDLIM2 expression. PMID: 19794962
    14. Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells PMID: 15659642
    15. PDLIM2 deficiency resulted in larger amounts of nuclear p65, defective p65 ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli PMID: 17468759
    16. Suppression of PDLIM2 expression resulted in decreased cell adhesion, increased NF-kappaB transcription reporter activity, and increased LPS-induced TNF-alpha production. PMID: 19052146

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=May be partially nuclear.; [Isoform 1]: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).; [Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 3]: Nucleus.
  • 數據庫鏈接：

    HGNC: 13992

    OMIM: 609722

    KEGG: hsa:64236

    STRING: 9606.ENSP00000312634

    UniGene: Hs.632034



主站蜘蛛池模板： 男女无遮挡猛进猛出免费观看视频| 国产精品久久久一区二区| 99re6热在线精品视频观看| 男人猛戳女人30分钟视频大全| 久久精品青青草原伊人| 国产极品粉嫩福利姬萌白酱| 免费人成视频x8x8入口| 国产三级在线观看免费| 国产乱人伦av在线麻豆a| 欧美一区二区三区红桃小说| 国产av仑乱内谢| 亚洲精品1卡2卡三卡4卡乱码| 正在播放酒店约少妇高潮| 久久精品人人做人人爽| 久久亚洲一区二区三区四区| 久久精品国产精品亚洲下载| 无码无套少妇18p在线直播| 人妻少妇乱子伦无码专区| 99在线 | 亚洲| 久久人搡人人玩人妻精品| 国产成人无码www免费视频播放 | 亚洲日韩成人无码不卡网站| 久久亚洲国产精品123区| 日韩人妻精品无码一区二区三区| 国产男女猛烈无遮挡a片漫画| 69精品人人人人| 亚洲人成色7777在线观看| 色狠狠av一区二区三区| 日韩精品无码中文字幕一区二区| 中文字幕av无码不卡免费| 国产又黄又湿无遮挡免费视频| 亚洲午夜成人av电影| 天码av无码一区二区三区四区| 亚洲欧美日韩成人综合网| 老司机午夜精品视频资源| 亚洲va成无码人在线观看天堂| 免费观看全黄做爰大片国产| 国产无套内射普通话对白| 成人精品动漫一区二区| 久久一日本综合色鬼综合色| 国产欧美久久一区二区|