在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDLIM2 Antibody

  • 中文名稱:
    PDLIM2兔多克隆抗體
  • 貨號:
    CSB-PA856962LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA856962LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA856962LA01HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PDLIM2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDLIM2
  • 別名:
    FLJ34715 antibody; MYSTIQUE antibody; OTTHUMP00000162522 antibody; OTTHUMP00000205197 antibody; OTTHUMP00000205198 antibody; OTTHUMP00000205199 antibody; OTTHUMP00000205200 antibody; OTTHUMP00000205202 antibody; OTTHUMP00000205203 antibody; PDLI2_HUMAN antibody; Pdlim2 antibody; PDZ and LIM domain 2 (mystique) antibody; PDZ and LIM domain protein 2 antibody; PDZ-LIM protein mystique antibody; SLIM antibody; Stat-interacting LIM protein antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human PDZ and LIM domain protein 2 protein (161-284AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,PDLIM2 Antibody (CSB-PA856962LA01HU),的標記方式是Non-conjugated。對于PDLIM2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA856962LB01HU PDLIM2 Antibody, HRP conjugated ELISA
    FITC CSB-PA856962LC01HU PDLIM2 Antibody, FITC conjugated
    Biotin CSB-PA856962LD01HU PDLIM2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
  • 基因功能參考文獻:
    1. The results showed that (i) the use of SPR chip led to comparable data compared to on-column streptavidin beads, (ii) gravity flow and microflow in wash and elution steps provided better results than centrifugation, and (iii) type and concentration of detergent did not significantly affect the interactome data of cancer-associated PDLIM2. PMID: 30194080
    2. We conclude that inactivation of PDLIM2 is a recurrent finding in cHL and ALCL, promotes activation of inflammatory signaling pathways and thereby contributes to their pathogenesis PMID: 27538486
    3. Data show that shRNA mediated knockdown of PDZ and LIM domain protein 2 (PDLIM2) in both primary meningioma and schwannoma leads to significant reductions in cellular proliferation. PMID: 28126595
    4. PDLIM2 is epigenetically repressed in ovarian cancer development and inhibition of PDLIM2 promoted ovarian cancer growth both in vivo and in vitro via NOS2-derived nitric oxide signaling, leading to recruitment of M2 type macrophages. PMID: 26593252
    5. The suppression of PDLIM2 expression significantly reduced cell proliferation, cell growth and neoplasm invasiveness in prostate cancer cells. PMID: 26499308
    6. epigenetic repression of PDLIM2 can be reversed by 5-aza-2-deoxycytidine and vitamin D to suppress KSHV-associated cancer cell growth PMID: 25681443
    7. PDLIM2 expression is essential for feedback regulation of the beta1-integrin-RhoA signalling axis and integration of cellular microenvironment signals with gene expression to control the polarity of breast epithelial acini structures. PMID: 24863845
    8. PDLIM2 integrates cytoskeleton signaling with gene expression in epithelial differentiation by controlling the stability of key transcription factors and COP9 signalosome activity. PMID: 24196835
    9. PDLIM2 was a direct target gene of 1,25(OH)2D3 PMID: 23584482
    10. Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases. PMID: 21814175
    11. PDLIM2 binds to Tax directly, which was mediated by a putative alpa-helix motif of PDLIM2 at amino acids 236-254. PMID: 20838382
    12. PDLIM2, an essential terminator of NF-kappaB activation, is repressed in both estrogen receptor-positive and estrogen receptor-negative breast cancer cells, suggesting one important mechanism for the constitutive activation of NF-kappaB. PMID: 20185823
    13. Data show that the PDLIM2 repression was independent of the viral regulatory protein Tax because neither short-term induction nor long-term stable expression of Tax could downregulate PDLIM2 expression. PMID: 19794962
    14. Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells PMID: 15659642
    15. PDLIM2 deficiency resulted in larger amounts of nuclear p65, defective p65 ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli PMID: 17468759
    16. Suppression of PDLIM2 expression resulted in decreased cell adhesion, increased NF-kappaB transcription reporter activity, and increased LPS-induced TNF-alpha production. PMID: 19052146

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=May be partially nuclear.; [Isoform 1]: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).; [Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 3]: Nucleus.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 13992

    OMIM: 609722

    KEGG: hsa:64236

    STRING: 9606.ENSP00000312634

    UniGene: Hs.632034



主站蜘蛛池模板: 免费人成视频网站在线下载| 久久久一本精品99久久精品66| 国产在线永久视频| 永久免费无码av在线网站| 成人欧美一区在线视频| 日韩精品一区二区在线观看| 中文毛片无遮挡高潮免费| 任我撸在线视频| 亚洲欧美日韩中文在线制服 | 免费精品国产自在| 狠狠躁夜夜躁人人爽天天bl| 午夜成人爽爽爽视频在线观看| 加勒比一本heyzo高清视频| 精品无码久久久久国产app | 久久青青草原国产精品最新片| 日韩av无码精品人妻系列| 国产9 9在线 | 欧洲| 国产成人av性色在线影院色戒| 久久成人影院精品99| 东京热人妻无码一区二区av | 国产suv精品一区二区四| 中文字幕av免费专区| 国产亚洲日韩在线a不卡| 无码精品a∨在线观看十八禁| 精品亚洲成a人在线观看青青| 久久国产乱子伦精品免费午夜| 国产私人尤物无码不卡| 成人h视频在线观看| 国产精品欧美亚洲韩国日本久久| 亚洲日本成本人观看| 波多野结衣潮喷视频无码42| 骚虎成人免费99xx| 丁香五月激情综合色婷婷| 亚洲日本va午夜在线电影| 中文无码一区二区不卡αv| 麻豆一区二区在我观看| 丰满妇女强制高潮18xxxx| 日韩精品久久久免费观看| 国产传媒精品1区2区3区| 日本成熟少妇喷浆视频| 亚洲欧洲自拍拍偷精品网|