在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDLIM2 Antibody, FITC conjugated

  • 中文名稱:
    PDLIM2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA856962LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PDLIM2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDLIM2
  • 別名:
    FLJ34715 antibody; MYSTIQUE antibody; OTTHUMP00000162522 antibody; OTTHUMP00000205197 antibody; OTTHUMP00000205198 antibody; OTTHUMP00000205199 antibody; OTTHUMP00000205200 antibody; OTTHUMP00000205202 antibody; OTTHUMP00000205203 antibody; PDLI2_HUMAN antibody; Pdlim2 antibody; PDZ and LIM domain 2 (mystique) antibody; PDZ and LIM domain protein 2 antibody; PDZ-LIM protein mystique antibody; SLIM antibody; Stat-interacting LIM protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human PDZ and LIM domain protein 2 protein (161-284AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
  • 基因功能參考文獻:
    1. The results showed that (i) the use of SPR chip led to comparable data compared to on-column streptavidin beads, (ii) gravity flow and microflow in wash and elution steps provided better results than centrifugation, and (iii) type and concentration of detergent did not significantly affect the interactome data of cancer-associated PDLIM2. PMID: 30194080
    2. We conclude that inactivation of PDLIM2 is a recurrent finding in cHL and ALCL, promotes activation of inflammatory signaling pathways and thereby contributes to their pathogenesis PMID: 27538486
    3. Data show that shRNA mediated knockdown of PDZ and LIM domain protein 2 (PDLIM2) in both primary meningioma and schwannoma leads to significant reductions in cellular proliferation. PMID: 28126595
    4. PDLIM2 is epigenetically repressed in ovarian cancer development and inhibition of PDLIM2 promoted ovarian cancer growth both in vivo and in vitro via NOS2-derived nitric oxide signaling, leading to recruitment of M2 type macrophages. PMID: 26593252
    5. The suppression of PDLIM2 expression significantly reduced cell proliferation, cell growth and neoplasm invasiveness in prostate cancer cells. PMID: 26499308
    6. epigenetic repression of PDLIM2 can be reversed by 5-aza-2-deoxycytidine and vitamin D to suppress KSHV-associated cancer cell growth PMID: 25681443
    7. PDLIM2 expression is essential for feedback regulation of the beta1-integrin-RhoA signalling axis and integration of cellular microenvironment signals with gene expression to control the polarity of breast epithelial acini structures. PMID: 24863845
    8. PDLIM2 integrates cytoskeleton signaling with gene expression in epithelial differentiation by controlling the stability of key transcription factors and COP9 signalosome activity. PMID: 24196835
    9. PDLIM2 was a direct target gene of 1,25(OH)2D3 PMID: 23584482
    10. Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases. PMID: 21814175
    11. PDLIM2 binds to Tax directly, which was mediated by a putative alpa-helix motif of PDLIM2 at amino acids 236-254. PMID: 20838382
    12. PDLIM2, an essential terminator of NF-kappaB activation, is repressed in both estrogen receptor-positive and estrogen receptor-negative breast cancer cells, suggesting one important mechanism for the constitutive activation of NF-kappaB. PMID: 20185823
    13. Data show that the PDLIM2 repression was independent of the viral regulatory protein Tax because neither short-term induction nor long-term stable expression of Tax could downregulate PDLIM2 expression. PMID: 19794962
    14. Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells PMID: 15659642
    15. PDLIM2 deficiency resulted in larger amounts of nuclear p65, defective p65 ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli PMID: 17468759
    16. Suppression of PDLIM2 expression resulted in decreased cell adhesion, increased NF-kappaB transcription reporter activity, and increased LPS-induced TNF-alpha production. PMID: 19052146

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=May be partially nuclear.; [Isoform 1]: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).; [Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 3]: Nucleus.
  • 數據庫鏈接:

    HGNC: 13992

    OMIM: 609722

    KEGG: hsa:64236

    STRING: 9606.ENSP00000312634

    UniGene: Hs.632034



主站蜘蛛池模板: 少妇人妻久久无码专区| 久久亚洲精品ab无码播放| 欧美亚洲人成网站在线观看| 国产亚洲日韩av在线播放不卡 | 最近更新中文字幕| 人妻丰满被色诱中文字幕 | 大地资源网第二页免费观看| 日本牲交大片免费观看| 成年无码av片在线免缓冲| 大伊香蕉精品视频在线直播| 亚洲欧美日韩精品久久| 韩国精品一区二区三区无码视频| 日韩av爽爽爽久久久久久| 99热成人精品热久久| 欧美xxxxx高潮喷水| 爆乳熟妇一区二区三区| av无码人妻无码男人的天堂| 亚洲国产中文曰韩丝袜| 国产欧美亚洲精品a第一页| 疯狂做受xxxx高潮视频免费| 西西人体扒开下部试看120秒| 让少妇高潮无乱码高清在线观看| 欧美性大战久久久久xxx| 久久国产色av免费看| 国产国产久热这里只有精品| 久久996re热这里有精品| 久久国产福利国产秒拍| 久久精品国产亚洲一区二区| 亚洲日本中文字幕乱码在线| 人妻在线无码一区二区三区| 亚洲日韩成人av无码网站| 欧美熟妇丰满肥白大屁股免费视频| 内谢少妇xxxxx8老少交| 无码办公室丝袜ol中文字幕| 中文字幕av在线一二三区| 亚洲午夜无码久久久久小说| 亚洲人成电影网站在线观看| 亚洲精品亚洲人成人网| 久久香蕉国产线看观看手机| 正在播放国产剧情亂倫| 亚洲日韩乱码一区二区三区四区|