在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human PAXIP1-associated protein 1 (PA1)

  • 中文名稱(chēng):
    人PAGR1重組蛋白
  • 貨號(hào):
    CSB-YP883597HU
  • 說(shuō)明書(shū):
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱(chēng):
    人PAGR1重組蛋白
  • 貨號(hào):
    CSB-EP883597HU
  • 說(shuō)明書(shū):
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱(chēng):
    人PAGR1重組蛋白
  • 貨號(hào):
    CSB-EP883597HU-B
  • 說(shuō)明書(shū):
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱(chēng):
    人PAGR1重組蛋白
  • 貨號(hào):
    CSB-BP883597HU
  • 說(shuō)明書(shū):
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱(chēng):
    人PAGR1重組蛋白
  • 貨號(hào):
    CSB-MP883597HU
  • 說(shuō)明書(shū):
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    PAGR1
  • Uniprot No.:
  • 別名:
    C16orf53; Chromosome 16 open reading frame 53; FLJ22459; GAS; Glutamate rich coactivator interacting with SRC1/NCOA1; MGC4606; Pa1; PA1_HUMAN; PAXIP1 associated protein 1; PAXIP1-associated protein 1; PTIP associated 1 protein; PTIP associated protein 1; PTIP-associated protein 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-254
  • 氨基酸序列
    MSLARGHGDT AASTAAPLSE EGEVTSGLQA LAVEDTGGPS ASAGKAEDEG EGGREETERE GSGGEEAQGE VPSAGGEEPA EEDSEDWCVP CSDEEVELPA DGQPWMPPPS EIQRLYELLA AHGTLELQAE ILPRRPPTPE AQSEEERSDE EPEAKEEEEE KPHMPTEFDF DDEPVTPKDS LIDRRRTPGS SARSQKREAR LDKVLSDMKR HKKLEEQILR TGRDLFSLDS EDPSPASPPL RSSGSSLFPR QRKY
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent.
  • 基因功能參考文獻(xiàn):
    1. PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer. PMID: 24260416
    2. PA1 expression was observed in both nucleus (mainly)and cytoplasm from breast cancer tissue samples. PA1 nuclear expression was correlated with postmenopausal, smaller tumor size, negative Ki67, positive AR and positive ERbeta. PA1 nuclear positive cases seemed to have a longer survival than negative ones for RFS. For those patients without lymphnode metastasis PA1 was found to be an independent prognostic factor for RFS. PMID: 24260416
    3. PA1 is a new competitive decelerator of GR transactivation and can act at more than one molecularly defined step in a manner that depends upon the specific gene PMID: 23161582
    4. GAS is a new transcription cofactor PMID: 19039327
    5. subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage. PMID: 19124460
    6. PA1 (C16orf53) binds PTIP directly and requires PTIP for interaction with the MLL3- and MLL4-containing histone H3 K4 methyltransferase complex. PMID: 17500065

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus.
  • 組織特異性:
    Ubiquitously expressed.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 28707

    OMIM: 612033

    KEGG: hsa:79447

    STRING: 9606.ENSP00000326519

    UniGene: Hs.702841



主站蜘蛛池模板: 麻豆成人久久精品二区三区免费| 欧美伊人久久大香线蕉综合| 中文字幕丰满乱子伦无码专区| 人妻少妇一区二区三区| 网友自拍区视频精品| 国产福利男女xx00视频| 国产亚洲va在线电影| 国产成人精品午夜福利不卡| 放荡的少妇2欧美版| 国产亚洲精品自在久久| 国产精品久免费的黄网站| 婷婷色香合缴缴情av第三区| 8ⅹ8x擦拨擦拨成人免费视频| 国产成av人片久青草影院| √天堂资源在线中文8在线最新版| 亚洲精品一区久久久久一品av| 亚洲国产一区二区三区| 野花社区在线www日本| 亚洲中文字幕无码一去台湾| 色欲aⅴ 无码| 日本一区二区三区免费高清| 精品人妻av一区二区三区| 无码人妻久久一区二区三区不卡 | 国产超碰人人做人人爽av| 欧美成人性做爰77777| 人妻无码久久一区二区三区免费 | 免费无码午夜福利片69| 99久久精品国产波多野结衣| 中文字幕在线无码一区二区三区| 99国产精品白浆在线观看免费 | 亚洲午夜福利精品无码不卡 | 成人无码www免费视频| 青草视频在线观看视频| 中文日产乱幕九区无线码| 特级a欧美做爰片第一次| 无码任你躁久久久久久| 97人妻精品一区二区三区| 暖暖 免费 高清 日本 在线| 久久久噜噜噜久久熟女| 99精品国产福久久久久久| 人妻熟女一区|