Recombinant Human Nucleolar GTP-binding protein 2 (GNL2)

中文名稱：

人GNL2重組蛋白
貨號：

CSB-YP618806HU
規格：
來源：

Yeast
其他：

中文名稱：

人GNL2重組蛋白
貨號：

CSB-EP618806HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人GNL2重組蛋白
貨號：

CSB-BP618806HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人GNL2重組蛋白
貨號：

CSB-MP618806HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

GNL2
Uniprot No.：

Q13823
別名：

Autoantigen NGP-1; Autoantigen NGP1; DJ423B22.6 (novel nucleolar guanosine 5'-triphosphate binding protein; FLJ40906; GNL2; Guanine nucleotide binding protein-like 2 (nucleolar); HUMAUANTIG; NGP1; NOG2_HUMAN; novel nucleolar guanosine 5'-triphosphate binding protein autoantigen; nucleolar G-protein gene 1; Nucleolar GTP binding protein 2; Nucleolar GTP-binding protein 2; Nucleolar GTPase
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-731
氨基酸序列

MVKPKYKGRS TINPSKASTN PDRVQGAGGQ NMRDRATIRR LNMYRQKERR NSRGKIIKPL QYQSTVASGT VARVEPNIKW FGNTRVIKQS SLQKFQEEMD TVMKDPYKVV MKQSKLPMSL LHDRIRPHNL KVHILDTESF ETTFGPKSQR KRPNLFASDM QSLIENAEMS TESYDQGKDR DLVTEDTGVR NEAQEEIYKK GQSKRIWGEL YKVIDSSDVV VQVLDARDPM GTRSPHIETY LKKEKPWKHL IFVLNKCDLV PTWATKRWVA VLSQDYPTLA FHASLTNPFG KGAFIQLLRQ FGKLHTDKKQ ISVGFIGYPN VGKSSVINTL RSKKVCNVAP IAGETKVWQY ITLMRRIFLI DCPGVVYPSE DSETDIVLKG VVQVEKIKSP EDHIGAVLER AKPEYISKTY KIDSWENAED FLEKLAFRTG KLLKGGEPDL QTVGKMVLND WQRGRIPFFV KPPNAEPLVA PQLLPSSSLE VVPEAAQNNP GEEVTETAGE GSESIIKEET EENSHCDANT EMQQILTRVR QNFGKINVVP QFSGDDLVPV EVSDLEEELE SFSDEEEEEQ EQQRDDAEES SSEPEEENVG NDTKAVIKAL DEKIAKYQKF LDKAKAKKFS AVRISKGLSE KIFAKPEEQR KTLEEDVDDR APSKKGKKRK AQREEEQEHS NKAPRALTSK ERRRAVRQQR PKKVGVRYYE THNVKNRNRN KKKTNDSEGQ KHKRKKFRQK Q
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.
基因功能參考文獻：
1. NGP-1 promotes cell cycle progression through the activation of the p53/p21(Cip-1/Waf1) pathway. PMID: 26203195
2. GNL2 and SEC13 are required for nonsense-mediated mRNA decay pathway in human cells. PMID: 25452588
亞細胞定位：

Nucleus, nucleolus.
蛋白家族：

TRAFAC class YlqF/YawG GTPase family, NOG2 subfamily
組織特異性：

Widely expressed, with the highest expression level in testis.
數據庫鏈接：

HGNC: 29925

OMIM: 609365

KEGG: hsa:29889

STRING: 9606.ENSP00000362153

UniGene: Hs.75528