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  4. Recombinant Human Nuclear pore complex protein Nup160 (NUP160), partial

Recombinant Human Nuclear pore complex protein Nup160 (NUP160), partial

  • 中文名稱：
    人NUP160重組蛋白
  • 貨號：
    CSB-YP614254HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NUP160重組蛋白
  • 貨號：
    CSB-EP614254HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NUP160重組蛋白
  • 貨號：
    CSB-EP614254HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NUP160重組蛋白
  • 貨號：
    CSB-BP614254HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NUP160重組蛋白
  • 貨號：
    CSB-MP614254HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NUP160
  • Uniprot No.：
  • 別名：
    160 kDa nucleoporin; DKFZp686M14102; FLJ22583; KIAA0197; MGC150678; MGC150679; NU160_HUMAN; Nuclear pore complex protein Nup160; Nucleoporin 160kD; Nucleoporin 160kDa; Nucleoporin Nup160; NUP 160; NUP120; Nup160
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Functions as a component of the nuclear pore complex (NPC). Involved in poly(A)+ RNA transport.
  • 基因功能參考文獻：
    1. Nup107-160 complex and its partner Elys dynamically colocalize with Nup98 and CRM1 into endogenous GLFG bodies present in specific HeLa sublines. PMID: 25904327
    2. transcriptome sequencing of patient-derived angiosarcoma cells, identified a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined. PMID: 26527604
    3. The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. PMID: 22031293
    4. The interactions of Nup160 with Pom121 and are predicted to assist in the formation of the nuclear pore and the anchoring of the Nuclear pore complexes to the pore membrane. PMID: 20974814
    5. A major function of the Nup107 complex in mitosis is to ensure the proper localization of the chromosome passenger complex at the centromere. PMID: 19864462
    6. Data show that Nup107-160 promotes spindle assembly through Ran-GTP-regulated nucleation of microtubules by gamma-TuRC at kinetochores, and reveal a relationship between nucleoporins and the microtubule cytoskeleton. PMID: 20081840
    7. Data show that structure-guided sequence comparison of Nup160 and Saccharomyces cerevisiae Nup120 strongly suggests that both proteins adopt the same unique fold despite a low sequence identity of 10%. PMID: 19576787
    8. Nup107-160 complex is dynamic in mitosis and that it promotes spindle assembly in a manner that is distinct from its functions at interphase nuclear pores. PMID: 16807356
    9. phosphorylation does not affect interactions within the Nup107-160 subcomplex, but regulates the association of the subcomplex with the NPC and other proteins PMID: 17360435
    10. These data thus provide the first molecular clues underlying the function of the human Nup107-160 complex at kinetochores. PMID: 17363900

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  • 亞細胞定位：
    Nucleus, nuclear pore complex.
  • 數據庫鏈接：

    HGNC: 18017

    OMIM: 607614

    KEGG: hsa:23279

    STRING: 9606.ENSP00000367721

    UniGene: Hs.643526



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