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  4. Recombinant Human Nuclear factor 1 X-type (NFIX)

Recombinant Human Nuclear factor 1 X-type (NFIX)

  • 中文名稱：
    人NFIX重組蛋白
  • 貨號：
    CSB-YP617941HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NFIX重組蛋白
  • 貨號：
    CSB-EP617941HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NFIX重組蛋白
  • 貨號：
    CSB-EP617941HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NFIX重組蛋白
  • 貨號：
    CSB-BP617941HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NFIX重組蛋白
  • 貨號：
    CSB-MP617941HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NFIX
  • Uniprot No.：
  • 別名：
    CCAAT box binding transcription factor; CCAAT-box-binding transcription factor; CTF; NF-I/X; NF1-X; NF1A; NF1X; NFI X; NFI-X; NFI/X; NFIX; NFIX_HUMAN; Nuclear factor 1 X type; Nuclear factor 1 X-type; Nuclear factor 1/X; Nuclear factor I/X; TGGCA binding protein; TGGCA-binding protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-502
  • 氨基酸序列
    MYSPYCLTQD EFHPFIEALL PHVRAFSYTW FNLQARKRKY FKKHEKRMSK DEERAVKDEL LGEKPEIKQK WASRLLAKLR KDIRPEFRED FVLTITGKKP PCCVLSNPDQ KGKIRRIDCL RQADKVWRLD LVMVILFKGI PLESTDGERL YKSPQCSNPG LCVQPHHIGV TIKELDLYLA YFVHTPESGQ SDSSNQQGDA DIKPLPNGHL SFQDCFVTSG VWNVTELVRV SQTPVATASG PNFSLADLES PSYYNINQVT LGRRSITSPP STSTTKRPKS IDDSEMESPV DDVFYPGTGR SPAAGSSQSS GWPNDVDAGP ASLKKSGKLD FCSALSSQGS SPRMAFTHHP LPVLAGVRPG SPRATASALH FPSTSIIQQS SPYFTHPTIR YHHHHGQDSL KEFVQFVCSD GSGQATGQPN GSGQGKVPGS FLLPPPPPVA RPVPLPMPDS KSTSTAPDGA ALTPPSPSFA TTGASSANRF VSIGPRDGNF LNIPQQSQSW FL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
  • 基因功能參考文獻：
    1. Microduplications encompassing NFIX cause intellectual disability, short stature and small head circumference. PMID: 29184170
    2. Compared to noncancerous esophageal mucosa, miR-1290 expression was upregulated, while NFIX mRNA expression was downregulated in ESCC tissues. Data suggest that the dysregulation of miR-1290-NFIX axis may play crucial roles in esophageal carcinogenesis and progression. PMID: 28800311
    3. A novel de novo pathogenic variant in the NFIX gene identified in a case of Marshall-Smith syndrome with precocious puberty and aortic root dilatation. PMID: 28442439
    4. Plasma miR-1914* and -1915 interact with NFIX RNA. PMID: 26695693
    5. Report novel mutations of NFIX gene causing Marshall-Smith syndrome or Sotos-like syndrome. PMID: 26200704
    6. miR-1290 functions as a tumor oncogene in the progression of esophageal squamous cell carcinoma by targeting NFIX PMID: 26653554
    7. NFIX analysis should be considered in patients presenting with overgrowth, macrocephaly and developmental delay including those in whom Sotos syndrome has been considered clinically but are negative for pathogenic NSD1 variants. PMID: 25118028
    8. Deletions in the 3' part of the NFIX gene including a recurrent Alu-mediated deletion of exon 6 and 7 account for previously unexplained cases of Marshall-Smith syndrome. PMID: 24924640
    9. missense mutations in NFIX were able to cause Sotos-like features. PMID: 22301465
    10. DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. PMID: 22422452
    11. NFI-X3 and STAT3 control the migration of differentiating astrocytes as well as migration and invasion of glioma cells via regulating YKL-40 expression. PMID: 21953450
    12. NFI-X3 activates GFAP expression, in part, by inducing alterations in the nucleosome architecture that lead to the increased recruitment of RNA polymerase II PMID: 21189253
    13. These findings demonstrate that allelic NFIX mutations trigger distinct phenotypes, depending specifically on their impact on nonsense-mediated mRNA decay. PMID: 20673863
    14. Nuclear factor IA may play a role in astrocytoma biology. PMID: 20150379
    15. NFI-X cooperates with (activator protein 1)AP-1 by an unknown mechanism in astrocytes, which results in the expression of a subset of astrocyte-specific genes. PMID: 16565071
    16. temporal and dose-dependent interference by an AP-1 family member, c-Jun, upon NF-1 proteins binding an NF-1 consensus site derived from JC virus promoter sequence PMID: 16928756
    17. First report of structural alterations of the NFIA gene in hematopoietic diseases (polycythemia vera and chronic myelomonocytic leukemia, type 1). PMID: 18754024
    18. an expression program of NFIs is executed during the differentiation of astrocytes, with NFI-X and -C controlling the expression of astrocytic markers at late stages of differentiation. PMID: 19418463

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  • 相關疾病：
    Sotos syndrome 2 (SOTOS2); Marshall-Smith syndrome (MRSHSS)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    CTF/NF-I family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 7788

    OMIM: 164005

    KEGG: hsa:4784

    STRING: 9606.ENSP00000380781

    UniGene: Hs.257970



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