在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human NmrA-like family domain-containing protein 1 (NMRAL1)

Recombinant Human NmrA-like family domain-containing protein 1 (NMRAL1)

  • 中文名稱：
    人NMRAL1重組蛋白
  • 貨號：
    CSB-YP867194HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NMRAL1重組蛋白
  • 貨號：
    CSB-EP867194HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NMRAL1重組蛋白
  • 貨號：
    CSB-EP867194HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NMRAL1重組蛋白
  • 貨號：
    CSB-BP867194HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NMRAL1重組蛋白
  • 貨號：
    CSB-MP867194HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NMRAL1
  • Uniprot No.：
  • 別名：
    FLJ25918 ; HSCARG; NmrA like family domain containing 1; NmrA like family domain containing protein 1; NmrA-like family domain-containing protein 1; NMRAL1; NMRL1_HUMAN; SDR48A1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-299
  • 氨基酸序列
    MVDKKLVVVF GGTGAQGGSV ARTLLEDGTF KVRVVTRNPR KKAAKELRLQ GAEVVQGDQD DQVIMELALN GAYATFIVTN YWESCSQEQE VKQGKLLADL ARRLGLHYVV YSGLENIKKL TAGRLAAAHF DGKGEVEEYF RDIGVPMTSV RLPCYFENLL SHFLPQKAPD GKSYLLSLPT GDVPMDGMSV SDLGPVVLSL LKMPEKYVGQ NIGLSTCRHT AEEYAALLTK HTRKVVHDAK MTPEDYEKLG FPGARDLANM FRFYALRPDR DIELTLRLNP KALTLDQWLE QHKGDFNLL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
  • 基因功能參考文獻：
    1. These findings suggest that the increased susceptibility of the G6PD-knockdown cells to viral infection was due to impaired NF-kappaB signaling and antiviral response mediated by HSCARG. PMID: 26694452
    2. Data indicate that HSCARG and USP7 function in concert in inhibiting polyubiquination of NEMO, thus inhibiting NF-kappaB activity. PMID: 24832601
    3. HSCARG is involved in DNA damage response through affecting the level of H2A ubiquitination and localization of RAP80 at lesion points. PMID: 24711370
    4. HSCARG regulated reactive-oxygen-species homeostasis through inhibition of NADPH oxidase activity via regulation of the expression of p47phox. PMID: 23527155
    5. CRM1 dependent nucleocytoplasmic translocation of HSCARG plays an important role in fine-tuning NF-kappaB signaling PMID: 22348310
    6. HSCARG is involved in the NF-kappaB signaling pathway, and negatively regulates NF-kappaB activation. PMID: 19843583
    7. expression, crystallization and preliminary X-ray crystallographic studies of HSCARG at a resolution of 2.4 A; crystals belong to F23 space group, with unit cell parameters a=b=c=223.30A, alpha=beta=gamma=90 degrees PMID: 17100653
    8. One of the functions regulated by HSCARG may be argininosuccinate synthetase that is involved in NO synthesis PMID: 17496144
    9. HSCARG regulation of argininosuccinate synthetase activity is crucial for maintaining the intracellular balance between redox state and nitric oxide levels PMID: 18263583
    10. In response to the changes in the NADPH/NADP(+) ratio within cells, HSCARG, as a redox sensor, associates and dissociates with NADPH to form a new dynamic equilibrium. PMID: 19254724
    11. HSCARG plays critical roles in regulation of NF-kappaB in response to cellular redox changes by promoting ubiquitination and proteolysis of RelA or COMMD1 PMID: 19433587

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.
  • 蛋白家族：
    NmrA-type oxidoreductase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24987

    KEGG: hsa:57407

    STRING: 9606.ENSP00000283429

    UniGene: Hs.288969



主站蜘蛛池模板： 国产98在线 | 欧美| 日韩在线一区二区不卡视频| 高大丰满欧美熟妇hd| 韩国主播av福利一区二区| 小荡货好紧好爽奶头大视频| √天堂中文www官网在线| 激情射精爆插热吻无码视频| 56pao国产成视频永久| 97se亚洲精品一区二区| 性开放的欧美大片| 国产成人精品优优av| 国产69精品久久久久乱码免费| 2020年无码国产精品高清免费| 国产免码va在线观看免费| 无码人妻熟妇av又粗又大| 亚洲欧美国产成人综合欲网| 成人无码α片在线观看不卡| 最新亚洲人成无码网站| 国模大胆一区二区三区| 国产乱子伦精品免费女| 艳妇乳肉豪妇荡乳在线观看 | 202丰满熟女妇大| 日韩精品极品视频在线观看免费| 国产成人啪精品视频网站| 九九热爱视频精品视频16| 欧美性受xxxx狂喷水| 色哟哟国产精品免费观看| 狼群社区www中文视频| 中文天堂最新版资源www官网| 欧美激情视频一区二区三区免费| 麻花传媒mv在线观看| 亚洲乱码中文论理电影| 免费网站看sm调教视频| 艳妇乳肉豪妇荡乳av| 国产国拍精品av在线观看| 久久国产免费观看精品a片| 午夜精品一区二区三区在线观看| 性人久久久久| 国产精品福利视频萌白酱| 久久久久久亚洲精品a片成人| 日韩在线不卡免费视频一区|