在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NMRAL1 Antibody, FITC conjugated

NMRAL1 Antibody, FITC conjugated

  • 中文名稱：
    NMRAL1兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA867194LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NMRAL1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NMRAL1
  • 別名：
    FLJ25918 antibody; HSCARG antibody; NmrA like family domain containing 1 antibody; NmrA like family domain containing protein 1 antibody; NmrA-like family domain-containing protein 1 antibody; NMRAL1 antibody; NMRL1_HUMAN antibody; SDR48A1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human NmrA-like family domain-containing protein 1 protein (1-299AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
  • 基因功能參考文獻：
    1. These findings suggest that the increased susceptibility of the G6PD-knockdown cells to viral infection was due to impaired NF-kappaB signaling and antiviral response mediated by HSCARG. PMID: 26694452
    2. Data indicate that HSCARG and USP7 function in concert in inhibiting polyubiquination of NEMO, thus inhibiting NF-kappaB activity. PMID: 24832601
    3. HSCARG is involved in DNA damage response through affecting the level of H2A ubiquitination and localization of RAP80 at lesion points. PMID: 24711370
    4. HSCARG regulated reactive-oxygen-species homeostasis through inhibition of NADPH oxidase activity via regulation of the expression of p47phox. PMID: 23527155
    5. CRM1 dependent nucleocytoplasmic translocation of HSCARG plays an important role in fine-tuning NF-kappaB signaling PMID: 22348310
    6. HSCARG is involved in the NF-kappaB signaling pathway, and negatively regulates NF-kappaB activation. PMID: 19843583
    7. expression, crystallization and preliminary X-ray crystallographic studies of HSCARG at a resolution of 2.4 A; crystals belong to F23 space group, with unit cell parameters a=b=c=223.30A, alpha=beta=gamma=90 degrees PMID: 17100653
    8. One of the functions regulated by HSCARG may be argininosuccinate synthetase that is involved in NO synthesis PMID: 17496144
    9. HSCARG regulation of argininosuccinate synthetase activity is crucial for maintaining the intracellular balance between redox state and nitric oxide levels PMID: 18263583
    10. In response to the changes in the NADPH/NADP(+) ratio within cells, HSCARG, as a redox sensor, associates and dissociates with NADPH to form a new dynamic equilibrium. PMID: 19254724
    11. HSCARG plays critical roles in regulation of NF-kappaB in response to cellular redox changes by promoting ubiquitination and proteolysis of RelA or COMMD1 PMID: 19433587

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.
  • 蛋白家族：
    NmrA-type oxidoreductase family
  • 數據庫鏈接：

    HGNC: 24987

    KEGG: hsa:57407

    STRING: 9606.ENSP00000283429

    UniGene: Hs.288969



主站蜘蛛池模板： 国产女人和拘做受视频免费 | 成年性午夜无码免费视频| 亚洲狠狠成人网| 国产高清卡1卡2卡3麻豆| 日韩精品一区国产偷窥在线| 粗大的内捧猛烈进出少妇视频| 免费国产成人午夜福利电影| 狠狠色丁香久久婷婷综合_中| 成人网站www污污污网站 | 超薄丝袜足j好爽在线观看| 无码av无码天堂资源网影音先锋 | 精品国产一区二区三区av性色| 日韩视频在线观看| 国产亚洲日韩在线播放更多| 国产一区二区三区精品av| 国产欧洲精品自在自线官方 | 国产成人精品日本亚洲| 18禁无遮挡羞羞污污污污网站| 无码专区无码专区视频网址| 欧美日韩亚洲国内综合网| 欧亚乱熟女一区二区在线| 国产97色在线 | 日韩| 好爽…又高潮了免费毛片| 亚洲制服丝袜av一区二区三区| 成人性欧美丨区二区三区| 亚洲成av人影院无码不卡| 激情内射亚洲一区二区三区| 国产女人被狂躁到高潮小说| 国产乱妇无乱码大黄aa片| 无码av免费永久免费永久专区| 四虎成人欧美精品在永久在线| 色偷偷久久一区二区三区| 国产高清自产拍av在线| 国产伦精品一区二区三区免费| 337p西西人体大胆瓣开下部| 午夜福利体验免费体验区| 国产av区男人的天堂| 亚洲精品国产自在现线最新| 夜夜高潮夜夜爽夜夜爱爱一区| 日本无码欧美一区精品久久 | 亚洲中文字幕在线无码一区二区|