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  4. Recombinant Human Neutrophil defensin 4 (DEFA4)

Recombinant Human Neutrophil defensin 4 (DEFA4)

  • 中文名稱：
    Recombinant Human Neutrophil defensin 4(DEFA4)
  • 貨號(hào)：
    CSB-YP006656HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Neutrophil defensin 4(DEFA4)
  • 貨號(hào)：
    CSB-EP006656HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Neutrophil defensin 4(DEFA4)
  • 貨號(hào)：
    CSB-EP006656HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Neutrophil defensin 4(DEFA4)
  • 貨號(hào)：
    CSB-BP006656HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Neutrophil defensin 4(DEFA4)
  • 貨號(hào)：
    CSB-MP006656HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DEFA4
  • Uniprot No.：
  • 別名：
    DEFA4; DEF4Neutrophil defensin 4; Defensin; alpha 4; HNP-4; HP-4
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Cytoplasmic domain
  • 表達(dá)區(qū)域：
    64-96
  • 氨基酸序列
    VCSCRLV FCRRTELRVG NCLIGGVSFT YCCTRV
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.
  • 基因功能參考文獻(xiàn)：
    1. DEFA4 displays antimicrobial activity against E. coli, S. faecalis, and C. albicans. PMID: 2500436
    2. DEFA1-3 and DEFA4 mRNA level in peripheral blood cells can be used to identify chronic myeloid leukaemia patients who are at risk of being imatinib-resistant, before initiation of the therapy. PMID: 21734341
    3. The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation. PMID: 20727496
    4. Crystal structure of HNP-4. PMID: 17088326
    5. DEFA4 was upregulated in IPF patients with acute exacerbation PMID: 19363140

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Alpha-defensin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2763

    OMIM: 601157

    KEGG: hsa:1669

    STRING: 9606.ENSP00000297435

    UniGene: Hs.591391



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