在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Neutral ceramidase (ASAH2), partial

Recombinant Human Neutral ceramidase (ASAH2), partial

  • 中文名稱：
    Recombinant Human Neutral ceramidase(ASAH2),partial
  • 貨號(hào)：
    CSB-YP865115HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Neutral ceramidase(ASAH2),partial
  • 貨號(hào)：
    CSB-EP865115HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Neutral ceramidase(ASAH2),partial
  • 貨號(hào)：
    CSB-BP865115HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Neutral ceramidase(ASAH2),partial
  • 貨號(hào)：
    CSB-MP865115HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ASAH2
  • Uniprot No.：
  • 別名：
    Acylsphingosine deacylase 2; AI585898; ASAH2; ASAH2_HUMAN; BCDase; hCD; HNAC1; LCDase; MGC129777 ; mitochondrial ceramidase; N acylsphingosine amidohydrolase (non lysosomal ceramidase) 2; N acylsphingosine amidohydrolase 2; N CDase; N-acylsphingosine amidohydrolase 2; N-CDase; NCDase; Neutral ceramidase soluble form; Non lysosomal ceramidase; Non-lysosomal ceramidase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells. Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells. This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract.
  • 基因功能參考文獻(xiàn)：
    1. The structural basis for ceramide recognition and hydrolysis by human neutral ceramidase has been uncovered. PMID: 26190575
    2. These results demonstrate for the first time that adiponectin inhibits TNFalpha-induced inflammatory response via Cav1-mediated ceramidase recruitment and activation in an AdipoR1-dependent fashion. PMID: 24397980
    3. cloned a 3000 bp region upstream of the translational start site of the nCDase gene PMID: 21531200
    4. c-Jun/AP-1 signaling may, in part, regulate serum-induced nCDase gene transcription PMID: 21530485
    5. Both acidic ceramidase (aCDase) and neutral ceramidase (nCDase) activities declined after low- and high-UVB, but returned to normal only in low-UVB cells PMID: 20520628
    6. Blocking acid ceramidase but not sphingosine kinase activity in alveolar macrophages led to decreased ERK and Akt activity and induction of cell death. PMID: 15210766
    7. Neutral ceramidase is localized mainly in plasma membranes. PMID: 15845354
    8. the present study identified a novel amidase sequence containing a critical serine residue that may function as a nucleophile in the hydrolytic attack on the amide bond present in ceramide PMID: 16229686
    9. Important for the generation of sphgosine 1 phosphqte (S1P) and S1P-mediated cell proliferation and survival. PMID: 16940153
    10. the purification and characterization of neutral ceramidase from human ileostomy content, using octanoyl-[(14)C]sphingosine as substrate PMID: 17475390
    11. serine palmitoyltransferase and ceramidase are two major ceramide metabolizing enzymes that may have roles in psoriatic epidermis PMID: 17982236

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Neutral ceramidase]: Cell membrane; Single-pass type II membrane protein. Membrane raft; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Mitochondrion. Secreted, extracellular exosome.; [Neutral ceramidase soluble form]: Secreted.
  • 蛋白家族：
    Neutral ceramidase family
  • 組織特異性：
    Primarily expressed in intestine. Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart. The ubiquitous expression observed for ASAH2 might be an experimental artifact due to the paralog ASAH2B.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18860

    OMIM: 611202

    KEGG: hsa:56624

    STRING: 9606.ENSP00000378897

    UniGene: Hs.512645



主站蜘蛛池模板： 男男又爽又黄又无遮挡网站| 国产日产亚洲系列最新美使用方法| 小12萝裸体视频国产| 色综合天天综合欧美综合| 亚洲综合另类小说专区| 午夜影视免费| 国产精品久久久久久吹潮| 欧美高清精品一区二区| 久久久国产精品va麻豆| 亚洲人成网站18禁止一区| 黑人大荫蒂老太大| 免费国产黄网站在线观看视频| 暖暖视频 免费 日本社区| 亚洲精品国产av成拍色拍婷婷| 欧美伊人久久大香线蕉综合| 超碰色偷偷男人的天堂| 日本人妻中文字幕乱码系列 | 日韩人妻少妇一区二区| 婷婷丁香社区| 精品一区二区ww| 最近中文字幕免费大全在线| 国产精品免费久久久久软件| 精品一区二区三区在线成人| 欧美 国产日韩 综合在线| 国产亚洲999精品aa片在线爽| 午夜福利92国语| 国产精品情侣呻吟对白视频| 国内精品九九久久久精品| 国产成年女人特黄特色毛片免| 欧美黑人大战白嫩在线| 波多野结衣一区二区三区高清 | 国产成人无码精品一区二区三区| 强行从后面挺进人妻| 免费看成人aa片无码视频吃奶| 男人扒开女人内裤强吻桶进去| 欲香欲色天天综合久久| 又大又紧又粉嫩18p少妇| 无码中文字幕色专区| 成人影院yy111111在线| 天码人妻一区二区三区| 少妇内射高潮福利炮|