在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Neutral ceramidase (ASAH2), partial

Recombinant Human Neutral ceramidase (ASAH2), partial

  • 中文名稱：
    Recombinant Human Neutral ceramidase(ASAH2),partial
  • 貨號(hào)：
    CSB-YP865115HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Neutral ceramidase(ASAH2),partial
  • 貨號(hào)：
    CSB-EP865115HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Neutral ceramidase(ASAH2),partial
  • 貨號(hào)：
    CSB-BP865115HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Neutral ceramidase(ASAH2),partial
  • 貨號(hào)：
    CSB-MP865115HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ASAH2
  • Uniprot No.：
  • 別名：
    Acylsphingosine deacylase 2; AI585898; ASAH2; ASAH2_HUMAN; BCDase; hCD; HNAC1; LCDase; MGC129777 ; mitochondrial ceramidase; N acylsphingosine amidohydrolase (non lysosomal ceramidase) 2; N acylsphingosine amidohydrolase 2; N CDase; N-acylsphingosine amidohydrolase 2; N-CDase; NCDase; Neutral ceramidase soluble form; Non lysosomal ceramidase; Non-lysosomal ceramidase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells. Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells. This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract.
  • 基因功能參考文獻(xiàn)：
    1. The structural basis for ceramide recognition and hydrolysis by human neutral ceramidase has been uncovered. PMID: 26190575
    2. These results demonstrate for the first time that adiponectin inhibits TNFalpha-induced inflammatory response via Cav1-mediated ceramidase recruitment and activation in an AdipoR1-dependent fashion. PMID: 24397980
    3. cloned a 3000 bp region upstream of the translational start site of the nCDase gene PMID: 21531200
    4. c-Jun/AP-1 signaling may, in part, regulate serum-induced nCDase gene transcription PMID: 21530485
    5. Both acidic ceramidase (aCDase) and neutral ceramidase (nCDase) activities declined after low- and high-UVB, but returned to normal only in low-UVB cells PMID: 20520628
    6. Blocking acid ceramidase but not sphingosine kinase activity in alveolar macrophages led to decreased ERK and Akt activity and induction of cell death. PMID: 15210766
    7. Neutral ceramidase is localized mainly in plasma membranes. PMID: 15845354
    8. the present study identified a novel amidase sequence containing a critical serine residue that may function as a nucleophile in the hydrolytic attack on the amide bond present in ceramide PMID: 16229686
    9. Important for the generation of sphgosine 1 phosphqte (S1P) and S1P-mediated cell proliferation and survival. PMID: 16940153
    10. the purification and characterization of neutral ceramidase from human ileostomy content, using octanoyl-[(14)C]sphingosine as substrate PMID: 17475390
    11. serine palmitoyltransferase and ceramidase are two major ceramide metabolizing enzymes that may have roles in psoriatic epidermis PMID: 17982236

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Neutral ceramidase]: Cell membrane; Single-pass type II membrane protein. Membrane raft; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Mitochondrion. Secreted, extracellular exosome.; [Neutral ceramidase soluble form]: Secreted.
  • 蛋白家族：
    Neutral ceramidase family
  • 組織特異性：
    Primarily expressed in intestine. Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart. The ubiquitous expression observed for ASAH2 might be an experimental artifact due to the paralog ASAH2B.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18860

    OMIM: 611202

    KEGG: hsa:56624

    STRING: 9606.ENSP00000378897

    UniGene: Hs.512645



主站蜘蛛池模板： 亚洲成av人片无码bt种子下载| 亚洲成在人线免费观看| 久久久久有精品国产麻豆| 国内外精品激情刺激在线 | 一本大道无码av天堂| 国产欧美精品一区二区色综合| 国产亚洲精品久久久久久牛牛 | s级爆乳玩具酱国产vip皮裤| 四虎永久在线精品免费无码| 亚洲高清偷拍一区二区三区| 午夜免费啪视频| 欧美孕妇变态孕交粗暴| 一本大道东京热无码视频| 蜜臀av免费一区二区三区| 99久热在线精品视频观看| 免费观看又污又黄在线观看| 国产高清乱理伦片中文小说| 欧美国产精品日韩在线| 亚洲国产成人精品一区刚刚| 久久99日韩国产精品久久99| 国产日韩av免费无码一区二区三区| 国产人妻精品一区二区三区| 久久久噜噜噜久久熟女aa片| 色琪琪av中文字幕一区二区| 少妇高潮一区二区三区99| 国产又色又爽又刺激视频| 在线资源天堂www| 777米奇色狠狠888俺也去乱| 性人久久久久| 国产精品久久久久7777按摩| 男女边吃奶边做边爱视频| 久久亚洲中文字幕无码| 久久精品亚洲成在人线av麻豆| 黑人与中国少妇xxxx视频| 99精品国产成人一区二区 | 巨大黑人极品videos精品| 亚洲色在线v中文字幕| 秋霞午夜鲁丝片午夜精品| 亚洲中文字幕久久精品无码喷水| 小雪尝禁果又粗又大的视频| 国产丝袜在线精品丝袜|