在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ASAH2 Antibody

ASAH2 Antibody

  • 中文名稱：
    ASAH2兔多克隆抗體
  • 貨號：
    CSB-PA076840
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA076840(ASAH2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA076840(ASAH2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal kidney tissue, 293T cells, Primary antibody: CSB-PA076840(ASAH2 Antibody) at dilution 1/240, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ASAH2
  • 別名：
    Acylsphingosine deacylase 2 antibody; AI585898 antibody; ASAH2 antibody; ASAH2_HUMAN antibody; BCDase antibody; hCD antibody; HNAC1 antibody; LCDase antibody; MGC129777 antibody; mitochondrial ceramidase antibody; N acylsphingosine amidohydrolase (non lysosomal ceramidase) 2 antibody; N acylsphingosine amidohydrolase 2 antibody; N CDase antibody; N-acylsphingosine amidohydrolase 2 antibody; N-CDase antibody; NCDase antibody; Neutral ceramidase soluble form antibody; Non lysosomal ceramidase antibody; Non-lysosomal ceramidase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ASAH2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells. Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells. This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract.
  • 基因功能參考文獻：
    1. The structural basis for ceramide recognition and hydrolysis by human neutral ceramidase has been uncovered. PMID: 26190575
    2. These results demonstrate for the first time that adiponectin inhibits TNFalpha-induced inflammatory response via Cav1-mediated ceramidase recruitment and activation in an AdipoR1-dependent fashion. PMID: 24397980
    3. cloned a 3000 bp region upstream of the translational start site of the nCDase gene PMID: 21531200
    4. c-Jun/AP-1 signaling may, in part, regulate serum-induced nCDase gene transcription PMID: 21530485
    5. Both acidic ceramidase (aCDase) and neutral ceramidase (nCDase) activities declined after low- and high-UVB, but returned to normal only in low-UVB cells PMID: 20520628
    6. Blocking acid ceramidase but not sphingosine kinase activity in alveolar macrophages led to decreased ERK and Akt activity and induction of cell death. PMID: 15210766
    7. Neutral ceramidase is localized mainly in plasma membranes. PMID: 15845354
    8. the present study identified a novel amidase sequence containing a critical serine residue that may function as a nucleophile in the hydrolytic attack on the amide bond present in ceramide PMID: 16229686
    9. Important for the generation of sphgosine 1 phosphqte (S1P) and S1P-mediated cell proliferation and survival. PMID: 16940153
    10. the purification and characterization of neutral ceramidase from human ileostomy content, using octanoyl-[(14)C]sphingosine as substrate PMID: 17475390
    11. serine palmitoyltransferase and ceramidase are two major ceramide metabolizing enzymes that may have roles in psoriatic epidermis PMID: 17982236

    顯示更多

    收起更多

  • 亞細胞定位：
    [Neutral ceramidase]: Cell membrane; Single-pass type II membrane protein. Membrane raft; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Mitochondrion. Secreted, extracellular exosome.; [Neutral ceramidase soluble form]: Secreted.
  • 蛋白家族：
    Neutral ceramidase family
  • 組織特異性：
    Primarily expressed in intestine. Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart. The ubiquitous expression observed for ASAH2 might be an experimental artifact due to the paralog ASAH2B.
  • 數據庫鏈接：

    HGNC: 18860

    OMIM: 611202

    KEGG: hsa:56624

    STRING: 9606.ENSP00000378897

    UniGene: Hs.512645



主站蜘蛛池模板： √天堂资源在线中文8在线最新版| 四虎国产精品免费久久久| 色婷婷综合激情综在线播放 | 亚洲第一a在线观看网站| 玩弄丰满少妇xxxxx性多毛| 日韩欧美在线综合网| 狠狠精品干练久久久无码中文字幕| 国产精品美脚玉足脚交欧美| 免费国产白丝喷水娇喘视频| 色多多成视频人在线观看| 色老头精品午夜福利视频| 色婷婷五月综合色啪网| 国产精品人人妻人人爽人人牛| 少妇特黄a一区二区三区| 国产特级毛片aaaaaa| 成人午夜高潮刺激免费视频| 久久ee热这里只有精品| 亚洲欧美日韩综合俺去了| 精品 在线 视频 亚洲| 欧美老熟妇xb水多毛多| 亚洲一区二区女搞男| 人人妻人人爽人人澡av| 2021精品亚洲中文字幕| 亚洲丁香婷婷久久一区二区| 秋霞午夜成人久久电影网| 醉酒后少妇被疯狂内射视频| 熟妇丰满大屁股在线播放| 成人免费无码大片a毛片18| 一本色道久久88加勒比—综合 | 乱码av麻豆丝袜熟女系列| 日韩成人无码毛片一区二区| 国内偷窥一区二区三区视频| 人人爽人人爽人人爽| 伊伊综合在线视频无码| 色情久久久av熟女人妻网站| 成人免费毛片内射美女app| 欧美人伦禁忌dvd放荡欲情 | 性xxxx欧美老妇胖老太性多毛 | 久欠精品国国产99国产精2021| 国产md视频一区二区三区| 国产毛片欧美毛片久久久|