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  4. Recombinant Human NKG2D ligand 3 (ULBP3)

Recombinant Human NKG2D ligand 3 (ULBP3)

  • 中文名稱：
    人ULBP3重組蛋白
  • 貨號：
    CSB-YP883648HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ULBP3重組蛋白
  • 貨號：
    CSB-EP883648HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ULBP3重組蛋白
  • 貨號：
    CSB-EP883648HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ULBP3重組蛋白
  • 貨號：
    CSB-BP883648HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ULBP3重組蛋白
  • 貨號：
    CSB-MP883648HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ULBP3; N2DL3; RAET1N; UL16-binding protein 3; ALCAN-gamma; NKG2D ligand 3; N2DL-3; NKG2DL3; Retinoic acid early transcript 1N
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    30-217
  • 氨基酸序列
    D AHSLWYNFTI IHLPRHGQQW CEVQSQVDQK NFLSYDCGSD KVLSMGHLEE QLYATDAWGK QLEMLREVGQ RLRLELADTE LEDFTPSGPL TLQVRMSCEC EADGYIRGSW QFSFDGRKFL LFDSNNRKWT VVHAGARRMK EKWEKDSGLT TFFKMVSMRD CKSWLRDFLM HRKKRLEPTA PPTMAPG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
  • 基因功能參考文獻：
    1. this study shows an increase in ULBP3 level in alopecia areata incognita patients, which positively correlates with the age and duration of the disease PMID: 27142445
    2. Varicella-Zoster Virus differentially modulates expression of the NKG2D ligands by upregulating MICA expression and reducing ULBP2 and ULBP3 expression in the infected cells. PMID: 25995251
    3. This study provides for the first time, the c-Myc dependent regulation of NKG2D ligands, ULBP1/2/3 in acute myeloid leukemia. PMID: 24677544
    4. A greater expression of ULBP3 has also been found in hair follicles in scalp biopsy specimens from patients with active disease PMID: 21689246
    5. A miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination. PMID: 21320692
    6. genetic polymorphism among the ethnic groups PMID: 20219610
    7. Data show that UL142 prevents ULBP3 trafficking to the surface and protects transfected cells from NK-mediated cytotoxicity. PMID: 20530255
    8. As NKG2D ligand, ULBP3 are expressed on immature and mature dendritic cells and plays an important role in the cytotoxic effect of NK cells against iDC. PMID: 18394338
    9. ULBP3 binds to the NGK2D receptor and activates multiple signaling pathways in primary natural killer cells. PMID: 11777960
    10. ULBPs and MICA are expressed in lipid rafts at the cell surface of NK and T cells. PMID: 15051759
    11. Vpr specifically induces surface expression of the unique-long 16 binding proteins (ULBP)-1 and ULBP-2, but not ULBP-3 PMID: 19798433

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    MHC class I family
  • 數據庫鏈接：

    HGNC: 14895

    OMIM: 605699

    KEGG: hsa:79465

    STRING: 9606.ENSP00000356308

    UniGene: Hs.15422



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